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Akademický článek

Computing cell state discriminates the aberrant hematopoiesis and activated microenvironment in Myelodysplastic syndrome (MDS) through a single cell genomic study

Autor: Xinyu Guo, Wenyan Jin, Yuchen Wen, Zhiqin Wang, Xiaotong Ren, Zhaoyun Liu, Rong Fu, Zhigang Cai, Lijuan Li

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)

Abstract Background Myelodysplastic syndrome (MDS) is a complicated hematopoietic malignancy characterized by bone marrow (BM) dysplasia with symptoms like anemia, neutropenia, or thrombocytopenia. MDS exhibits considerable heterogeneity in prognosis

Externí odkaz: https://doaj.org/article/c5c0e8f4b0e844d2a0ad9963d12ce26e

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Akademický článek

NAT10 Promotes Prostate Cancer Growth and Metastasis by Acetylating mRNAs of HMGA1 and KRT8

Autor: Kang‐Jing Li, Yaying Hong, Yu‐Zhong Yu, Zhiyue Xie, Dao‐Jun Lv, Chong Wang, Tao Xie, Hong Chen, Zhe‐Sheng Chen, Jianwen Zeng, Shan‐Chao Zhao

Publikováno v: Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)

Abstract N4‐acetylcytidine (ac4C) is essential for the development and migration of tumor cells. According to earlier research, N‐acetyltransferase 10 (NAT10) can increase messenger RNAs (mRNAs) stability by catalyzing the synthesis of ac4C. Howe

Externí odkaz: https://doaj.org/article/cac7cd653f3b44c9b69f645b1ca0cbca

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Akademický článek

Influence of the High Mobility Group A1 genetic polymorphism on indices of metabolic syndrome and insulin resistance in the Iraqi population: Case-control study

Autor: Mirna Kifah Faiq, Eman Saadi Saleh, Omar Basher Fathalla

Publikováno v: Journal of Advanced Biotechnology and Experimental Therapeutics, Vol 6, Iss 2, Pp 326-336 (2023)

ABSTRACT: The high mobility group A1 gene (HMGA1) rs139876191 variant has been related to metabolic syndrome and type 2 diabetes, but data are lacking in Middle Eastern populations. The study aimed to assess whether the HMGA1 rs139876191 variant is a

Externí odkaz: https://doaj.org/article/cd43f8bf38a24ce5a96991aff9ae7715

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Akademický článek

Deciphering the molecular landscape: integrating single-cell transcriptomics to unravel myofibroblast dynamics and therapeutic targets in clear cell renal cell carcinomas

Autor: Wenqian Zhou, Zhiheng Lin, Wang Tan

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundClear cell renal cell carcinomas (ccRCCs) epitomize the most formidable clinical subtype among renal neoplasms. While the impact of tumor-associated fibroblasts on ccRCC progression is duly acknowledged, a paucity of literature exists eluci

Externí odkaz: https://doaj.org/article/00a46f6b35414c119abaf576d98921c8

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Akademický článek

HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma

Autor: Zhipeng Li, Huaxin Zhou, Zhijia Xia, Tong Xia, Gang Du, Strohmer Dorothee Franziska, Xiaoming Li, Xiangyu Zhai, Bin Jin

Publikováno v: Biomarker Research, Vol 11, Iss 1, Pp 1-12 (2023)

Abstract Background Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer that is challenging to diagnose at an early stage. Despite recent advances in combination chemotherapy, drug resistance limits the therapeutic value of this regi

Externí odkaz: https://doaj.org/article/1341c828fb7544848511065c2eae8fce

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Akademický článek

lncRNA TPT1-AS1 promotes cell migration and invasion in esophageal squamous-cell carcinomas by regulating the miR-26a/HMGA1 axis

Autor: Cheng Wenhua, Yang Fang, Ma Yong

Publikováno v: Open Medicine, Vol 18, Iss 1, Pp 394-424 (2023)

lncRNA TPT1-AS1 plays an oncogenic role in ovarian and cervical cancers. However, its involvement in the pathological progress of esophageal squamous-cell carcinomas (ESCCs) is unclear. lncRNA TPT1-AS1 was mainly localized in the cytoplasm of ESCC ce

Externí odkaz: https://doaj.org/article/07a69ebaf6154b2d9b969a25d0962640

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Akademický článek

Silencing of circ_002136 sensitizes gastric cancer to paclitaxel by targeting the miR-16-5p/HMGA1 axis

Autor: Kuang Zhijian, Yang Haitao, Cheng Shu, Zhou Xiaolong, Chen Lan, Zhang Yuqing, Zhang Jie

Publikováno v: Open Medicine, Vol 18, Iss 1, Pp 437-48 (2023)

The dysregulated expression of circRNA in gastric cancer (GC) induces paclitaxel (Tax) resistance of cancer cells, which in turn affects disease progression and prognosis. Here, we sought to investigate the role and mechanism of circ_002136 in Tax-re

Externí odkaz: https://doaj.org/article/bf2482865f344beba55ffe74e8d5d44c

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circ-LIMK1 regulates cisplatin resistance in lung adenocarcinoma by targeting miR-512-5p/HMGA1 axis

Autor: Li Ya, Li Fangfang, Wang Yaya, Song Fangyu, Qi Lin, Hu Qiang

Publikováno v: Open Medicine, Vol 17, Iss 1, Pp 1568-1583 (2022)

This study aimed to unveil the detailed role and new mechanism of circ-LIMK1 in lung adenocarcinoma. Real-time quantitative polymerase chain reaction was performed to analyze the expression of circ-LIMK1, miR-512-5p, and HMGA1. 3-(4,5)-Dimethylthiahi

Externí odkaz: https://doaj.org/article/551d5b1820a74ae391574e0e85d74cce

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Akademický článek

Lack of Association of the HMGA1 Gene Variants with Metabolic Syndrome Risk and Response to Oral Anti-Diabetic Drugs

Autor: Mirna K. Faiq, Eman S. Saleh, Omar B. Fathalla

Publikováno v: مجله كليه طب الكندي, Vol 19, Iss 2 (2023)

Background: Metabolic syndrome (Mets) is partially heritable. High mobility group AT-hook1 (HMGA1), an architectural transcription factor, affects the homeostasis of glucose. The marked inter-individual differences between T2DM patients in response t

Externí odkaz: https://doaj.org/article/3a48401d1d45428aaa37f7a605aa027f

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