Zobrazeno 1 - 10
of 10 145
pro vyhledávání: '"hiv-1 infection"'
Autor:
Ambada N. Georgia, Ntsama E. Claudine, Sake N. Carole, Ngu N. Loveline, Lissom Abel, Tchouangeu T. Flaurent, Sosso Martin, Alain Bopda Waffo, Malachy Okeke, Charles Esimone, Chae Gyu Park, Colizzi Vittorio, Etoa François-Xavier, Nchinda W. Godwin
Publikováno v:
BMC Immunology, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract We previously demonstrated that the overall number of regulatory T (Treg) cells decrease proportionately with helper CD4+ T cells and their frequencies increase in antiretroviral therapy (ART)-naive human immunodeficiency virus type-1 (HIV-1
Externí odkaz:
https://doaj.org/article/8e4cf8c0fab444f3963de1511ed75ead
Autor:
Stefan Schneider, Gary Blick, Christina Burke, Douglas Ward, Paul Benson, Franco Felizarta, Dallas Green, Cynthia Donovan, Gavin Harper, Deanna Merrill, Aimee A. Metzner, Katie Mycock, Hannah Wallis, Jimena Patarroyo, Andrew P. Brogan, Alan Oglesby
Publikováno v:
Infectious Diseases and Therapy, Vol 13, Iss 4, Pp 891-906 (2024)
Abstract Introduction Dolutegravir/lamivudine (DTG/3TC) and dolutegravir/rilpivirine (DTG/RPV) are fixed-dose, complete, single-tablet, two-drug regimens (2DRs) indicated for HIV-1. DTG/3TC is approved for antiretroviral therapy (ART)-naive people wi
Externí odkaz:
https://doaj.org/article/9326a0be8e4f46498103ec99f3e9f312
Autor:
Minh Ha Ngo, Joshua Pankrac, Ryan C. Y. Ho, Emmanuel Ndashimye, Rahul Pawa, Renata Ceccacci, Tsigereda Biru, Abayomi S. Olabode, Katja Klein, Yue Li, Colin Kovacs, Robert Assad, Jeffrey M. Jacobson, David H. Canaday, Stephen Tomusange, Samiri Jamiru, Aggrey Anok, Taddeo Kityamuweesi, Paul Buule, Ronald M. Galiwango, Steven J. Reynolds, Thomas C. Quinn, Andrew D. Redd, Jessica L. Prodger, Jamie F. S. Mann, Eric J. Arts
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTTo date, an affordable, effective treatment for an HIV-1 cure remains only a concept with most “latency reversal” agents (LRAs) lacking specificity for the latent HIV-1 reservoir and failing in early clinical trials. We assessed HIV-1 lat
Externí odkaz:
https://doaj.org/article/c4e48e2d64a24cd4aecbe0e0f13130b6
Autor:
Abraham Saborido-Alconchel, Ana Serna-Gallego, María Trujillo-Rodriguez, Esperanza Muñoz-Muela, Ana I. Álvarez-Ríos, Carmen Lozano, Silvia Llaves-Flores, Nuria Espinosa, Cristina Roca-Oporto, Marta Herrero, Cesar Sotomayor, Alicia Gutierrez-Valencia, Luis F. Lopez-Cortes
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectiveTo compare the long-term effects on immune parameters, inflammation, and HIV-1 reservoir after switching to a two-drug (2DR) versus maintaining an integrase inhibitor (InSTI)-based three-drug regimen (3DR).MethodsCross-sectional study in whi
Externí odkaz:
https://doaj.org/article/54a9b36fe1f346459b2724ba340f0505
Autor:
Oluwafemi Samuel Obisesan, Lesego L. Tshweu, Sipho Chauke, Kanyane Bridgett Malatji, Bathabile Ramalapa, Kabamba B. Alexandre, Hazel Tumelo Mufhandu
Publikováno v:
Nano Select, Vol 5, Iss 6, Pp n/a-n/a (2024)
Abstract The remarkable ability of the human immunodeficiency virus (HIV) to evade the host's immune system and conventional antiretroviral therapy, has posed significant challenges in achieving complete eradication of the virus in people living with
Externí odkaz:
https://doaj.org/article/ebbf7a40708049b8a18f6f4429573aeb
Autor:
Kewreshini K. Naidoo, Marcus Altfeld
Publikováno v:
Viruses, Vol 16, Iss 10, p 1584 (2024)
Natural killer (NK) cells are multifaceted innate effector cells that critically influence antiviral immunity, and several protective NK cell features that modulate HIV-1 acquisition and viral control have been described. Chronic HIV-1 infection lead
Externí odkaz:
https://doaj.org/article/3ec1c98cdf4b46bb9678a03db2bcdef7
Autor:
Matrona Akiso, Daniel Muema, Robert Langat, Kewreshini K. Naidoo, Geoffrey Oino, Gaudensia Mutua, Christina Thobakgale, Daniel Ochiel, Kundai Chinyenze, Omu Anzala, Marianne W. Mureithi
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTPhenotypic changes and functional impairment of natural killer (NK) cells occur early in HIV-1 infection. Antiretroviral therapy (ART) effectively restores CD4+ T cell counts and suppresses HIV-1 to undetectable levels. The role and efficacy
Externí odkaz:
https://doaj.org/article/f52239c635764d56b3f92749b49d7601
Autor:
Aurélie Ram, Vanessa Rascon Velasco, Gilbert Mchantaf, Véronique Avettand-Fénoël, Jean-Paul Viard
Publikováno v:
Journal of Virus Eradication, Vol 10, Iss 1, Pp 100370- (2024)
Background: The human immunodeficiency virus type 1 (HIV-1) cannot be eradicated even with suppressive antiretroviral therapy because its retrotranscribed genome integrates into the DNA of host cells, creating a long-term reservoir. Quantification of
Externí odkaz:
https://doaj.org/article/5ceb34de0d0c48de94d067037353157b
Autor:
Joanna Ireland, Jason Segura, Genbin Shi, Julianna Buchwald, Gwynne Roth, Thomas Juncheng Shen, Ruipeng Wang, Xinhua Ji, Elizabeth R. Fischer, Susan Moir, Tae-Wook Chun, Peter D. Sun
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
HIV-1 gp120 glycan binding to C-type lectin adhesion receptor L-selectin/CD62L on CD4 T cells facilitates viral attachment and entry. Paradoxically, the adhesion receptor impedes HIV-1 budding from infected T cells and the viral release requires the
Externí odkaz:
https://doaj.org/article/d1345b938a9e4d4b9d8558446242fdc7
Publikováno v:
Infectious Diseases and Therapy, Vol 12, Iss 10, Pp 2457-2469 (2023)
Abstract Introduction Ainuovirine/lamivudine/tenofovir is a novel antiretroviral therapy regimen used to treat human immunodeficiency virus-1 (HIV-1) infection. This study aimed to compare the pharmacokinetics of ainuovirine/lamivudine/tenofovir in H
Externí odkaz:
https://doaj.org/article/827bacca0b7d408baaf88f765de0bef8