Zobrazeno 1 - 10
of 11 654
pro vyhledávání: '"histone methyltransferase"'
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 775-782 (2024)
Understanding the precise mechanism of BMSC (bone marrow mesenchymal stem cell) osteogenesis is critical for metabolic bone diseases and bone reconstruction. The histone-lysine N-methyltransferase 2D (KMT2D) acts as an important methyltransferase rel
Externí odkaz:
https://doaj.org/article/9eb636875c48482ead6ca11bec1aae6a
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38582- (2024)
Gastric cancer, a common and severe malignancy, is associated with unfavorable outcomes and limited therapeutic options. The exploration of the potential link between plasma histone-modifying enzymes and gastric cancer through Mendelian randomization
Externí odkaz:
https://doaj.org/article/4e5cc26709144ffe9e1087965d444d6b
Autor:
Macario Osorio-Concepción, Carlos Lax, Damaris Lorenzo-Gutiérrez, José Tomás Cánovas-Márquez, Ghizlane Tahiri, Eusebio Navarro, Ulrike Binder, Francisco Esteban Nicolás, Victoriano Garre
Publikováno v:
IMA Fungus, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mucorales are basal fungi that opportunistically cause a potentially fatal infection known as mucormycosis (black fungus disease), which poses a significant threat to human health due to its high mortality rate and its recent association wit
Externí odkaz:
https://doaj.org/article/b9f413d3edd7414bab1b37a7c36dfcb4
Akademický článek
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Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch
Publikováno v:
SLAS Discovery, Vol 29, Iss 4, Pp 100161- (2024)
Methylation of proteins and nucleic acids plays a fundamental role in epigenetic regulation, and discovery of methyltransferase (MT) inhibitors is an area of intense activity. Because of the diversity of MTs and their products, assay methods that det
Externí odkaz:
https://doaj.org/article/b24641d39fdd403a8bd985ead3a395eb
Autor:
Belén Ocaña-Paredes, Sebastián Rivera-Orellana, David Ramírez-Sánchez, Juliana Montalvo-Guerrero, María Paula Freire, Samantha Espinoza-Ferrao, Adriana Altamirano-Colina, Paulina Echeverría-Espinoza, María José Ramos-Medina, Gabriela Echeverría-Garcés, Danilo Granda-Moncayo, Andrea Jácome-Alvarado, María Gabriela Andrade, Andrés López-Cortés
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Epigenetic modifications, characterized by changes in gene expression without altering the DNA sequence, play a crucial role in the development and progression of cancer by significantly influencing gene activity and cellular function. This insight h
Externí odkaz:
https://doaj.org/article/6aeb0f23da1d4129ad4c7d906668331a
Publikováno v:
Cell Insight, Vol 3, Iss 2, Pp 100151- (2024)
Epigenetic modifications, including DNA methylation and histone post-translational modifications, intricately regulate gene expression patterns by influencing DNA accessibility and chromatin structure in higher organisms. These modifications are heri
Externí odkaz:
https://doaj.org/article/22d074ddc9164b66afb301575015ea3e
Publikováno v:
Plant Stress, Vol 11, Iss , Pp 100303- (2024)
Abiotic stress greatly threaten plants’ growth and ultimately impact crop productivity. Plants have evolved sophisticated regulatory mechanisms to cope with stressful conditions, including undergoing physiological changes through genetic and epigen
Externí odkaz:
https://doaj.org/article/7292947df6e94893bf7de7868c95f8e7
Akademický článek
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Autor:
Harpreet Kaur, Syed Azmal Ali, Sarah P. Short, Christopher S. Williams, Jeremy A. Goettel, M. Kay Washington, Richard M. Peek, Sari A. Acra, Fang Yan
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTSeveral probiotic-derived factors have been identified as effectors of probiotics for exerting beneficial effects on the host. However, there is a paucity of studies to elucidate mechanisms of their functions. p40, a secretory protein, is ori
Externí odkaz:
https://doaj.org/article/fbd498869d1e4dc9a38573f75067729d