Zobrazeno 1 - 10
of 273
pro vyhledávání: '"histone lactylation"'
Autor:
Chenyang Liu, Qun Zhang, Hong Zhou, Linling Jin, Chang Liu, Mingxia Yang, Xinyun Zhao, Wenqiu Ding, Weiping Xie, Hui Kong
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background Pulmonary fibrosis is a serious interstitial lung disease with no viable treatment except for lung transplantation. Glucagon-like peptide-1 receptor (GLP-1R), commonly regarded as an antidiabetic target, exerts antifibrotic effect
Externí odkaz:
https://doaj.org/article/cf5a36068247478eb83c87e47a109837
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-13 (2024)
Abstract Objective Renal ischemia/reperfusion injury (IRI) is a major cause of acute kidney injury (AKI), which is associated with high incidence and mortality. AST-120 is an oral carbonaceous adsorbent that can alleviate kidney damage. This study ai
Externí odkaz:
https://doaj.org/article/b54589a5ef6b4a749be42eb632b239ca
Autor:
Fan Zhang, Jian Zhou, Peng Lu, Xianhui Zhang, Lei Yang, Jinpeng Wu, Lihan Zhang, Lifang Zhang, Jinwei Pang, Huangfan Xie, Bingqing Xie, Yong Jiang, Jianhua Peng
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Under subarachnoid hemorrhage (SAH) conditions, astrocytes undergo a marked intensification of glycolytic activity, resulting in the generation of substantial amounts of lactate to maintain the energy demand for neurons and other brain cells
Externí odkaz:
https://doaj.org/article/42449f0c8e3f42f3aa8c759e5e1fb2d7
Autor:
Mengdie Dong, Yunjia Zhang, Minghong Chen, Yongkang Tan, Jiao Min, Xian He, Fuhao Liu, Jiaming Gu, Hong Jiang, Longbin Zheng, Jiajing Chen, Quanwen Yin, Xuesong Li, Xiang Chen, Yongfeng Shao, Yong Ji, Hongshan Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 3027-3048 (2024)
Endothelial-to-mesenchymal transition (EndMT) is a key driver of atherosclerosis. Aerobic glycolysis is increased in the endothelium of atheroprone areas, accompanied by elevated lactate levels. Histone lactylation, mediated by lactate, can regulate
Externí odkaz:
https://doaj.org/article/d3ba451a29bb44e98b710d533a1ad252
Autor:
Yaozong Wei, Bo Pan, Jianpeng Qin, Beijia Cao, Tianyi Lv, Jiangfeng Ye, Ao Ning, Kunlin Du, Xiangyi Chen, Shuqi Zou, Shengqin Zang, Guozhi Yu, Tianzeng Song, Qiuxia Liang, Guangbin Zhou
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Previous studies have shown that the vitrification of metaphase II (MII) oocytes significantly represses their developmental potential. Abnormally increased oxidative stress is the probable factor; however, the underlying mechanis
Externí odkaz:
https://doaj.org/article/d72cf8aa90004871826a5254b0701dfd
Autor:
Shaobo Guo, Wenhui Zhu, Yuting Bian, Zhikai Li, Heng Zheng, Wenlong Li, Yi Yang, Xuzheng Ji, Biao Zhang
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37807- (2024)
Background: Research underscores the significant influence of histone lactylation pathways in the progression of Alzheimer's disease (AD), though the molecular mechanisms associated with histone lactylation-related genes (HLRGs) in AD are still insuf
Externí odkaz:
https://doaj.org/article/2c16ec939d7c468d9bf22e3fb54dc6d6
Autor:
Fei Li, Wenzhe Si, Li Xia, Deshan Yin, Tianjiao Wei, Ming Tao, Xiaona Cui, Jin Yang, Tianpei Hong, Rui Wei
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-24 (2024)
Abstract Background Metabolic reprogramming and epigenetic alterations contribute to the aggressiveness of pancreatic ductal adenocarcinoma (PDAC). Lactate-dependent histone modification is a new type of histone mark, which links glycolysis metabolit
Externí odkaz:
https://doaj.org/article/9d396e035776494eb85fe93d3a1b67c3
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
Osteoarthritis (OA) is a worldwide joint disease, leading to the physical pain, stiffness, and even disability. Lactate dehydrogenase A (LDHA) is known as a lactylation mediator that can regulate histone lactylation of its target genes. However, the
Externí odkaz:
https://doaj.org/article/d2cbd1710e834b98873a396db5072883
Autor:
Yu Zhang, Xiaobo Zhang
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract As “non‐cellular organisms”, viruses need to infect living cells to survive themselves. The virus infection must alter host's metabolisms. However, the influence of the metabolites from the altered metabolisms of virus‐infected host
Externí odkaz:
https://doaj.org/article/6d4886a94c1d45a498ff8f256cbccb1f
Publikováno v:
Redox Biology, Vol 74, Iss , Pp 103194- (2024)
Elevated lactate levels are a significant biomarker of sepsis and are positively associated with sepsis-related mortality. Sepsis-associated lung injury (ALI) is a leading cause of poor prognosis in clinical patients. However, the underlying mechanis
Externí odkaz:
https://doaj.org/article/b2e3f8255b9d47108a03acdb10a7f49c