Zobrazeno 1 - 10
of 1 101
pro vyhledávání: '"histone demethylation"'
Publikováno v:
口腔疾病防治, Vol 32, Iss 6, Pp 463-469 (2024)
Histone acetylation and methylation can affect chromatin conformation and regulate a variety of biological activities. Abnormal histone acetylation and methylation modifications are related to the occurrence and development of a variety of oral disea
Externí odkaz:
https://doaj.org/article/c83ef6d393f2414eb80d6e994ab2d980
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-23 (2024)
Abstract Breast cancer (BC) is the most frequent malignant cancer diagnosis and is a primary factor for cancer deaths in women. The clinical subtypes of BC include estrogen receptor (ER) positive, progesterone receptor (PR) positive, human epidermal
Externí odkaz:
https://doaj.org/article/d57aa245820d48ac86b7e2caee8cb632
Autor:
Guanjun Yang, Changyun Li, Fan Tao, Yanjun Liu, Minghui Zhu, Yu Du, Chenjie Fei, Qiusheng She, Jiong Chen
Publikováno v:
Genes and Diseases, Vol 11, Iss 2, Pp 645-663 (2024)
Lysine-specific demethylase 4 A (KDM4A, also named JMJD2A, KIA0677, or JHDM3A) is a demethylase that can remove methyl groups from histones H3K9me2/3, H3K36me2/3, and H1.4K26me2/me3. Accumulating evidence suggests that KDM4A is not only involved in b
Externí odkaz:
https://doaj.org/article/c6c64cbd4fb74fd984bde2ddb980cc76
Publikováno v:
Zhongguo aizheng zazhi, Vol 34, Iss 2, Pp 176-184 (2024)
Background and purpose: Exogenous bone morphogenetic protein 9 (BMP9) inhibits the malignant progression of human breast cancer, but its expression is often abnormally low in breast cancer. In this study, we intended to explore the expression and rol
Externí odkaz:
https://doaj.org/article/61311807071945a38296ffd5392a0dc7
Autor:
Maria Carla Borroto, Coralie Michaud, Chloé Hudon, Pankaj B. Agrawal, Katherine Agre, Carolyn D. Applegate, Alan H. Beggs, Hans T. Bjornsson, Bert Callewaert, Mei-Jan Chen, Cynthia Curry, Orrin Devinsky, Tracy Dudding-Byth, Kelly Fagan, Candice R. Finnila, Ralitza Gavrilova, Casie A. Genetti, Susan M. Hiatt, Friedhelm Hildebrandt, Monica H. Wojcik, Tjitske Kleefstra, Caroline M. Kolvenbach, Bruce R. Korf, Paul Kruszka, Hong Li, Jessica Litwin, Julien Marcadier, Konrad Platzer, Patrick R. Blackburn, Margot R. F. Reijnders, Heiko Reutter, Ina Schanze, Joseph T. Shieh, Cathy A. Stevens, Zaheer Valivullah, Marie-José van den Boogaard, Eric W. Klee, Philippe M. Campeau
Publikováno v:
Genes, Vol 15, Iss 8, p 1033 (2024)
Bi-allelic disruptive variants (nonsense, frameshift, and splicing variants) in KDM5B have been identified as causative for autosomal recessive intellectual developmental disorder type 65. In contrast, dominant variants, usually disruptive as well, h
Externí odkaz:
https://doaj.org/article/bd7727c240f64782b2e5faaddbf4ec0a
Autor:
Yuanbin Liu, Mingkai Chen
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 4, Pp 3640-3657 (2023)
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease with multifactorial pathogenesis; histone demethylases (HDMs) are emerging as attractive targets. We identified HDM genes (including KDM5C, KDM6B, KDM8, KDM4A, and JMJD
Externí odkaz:
https://doaj.org/article/f70c25487db1409b9268f26758246369
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 262, Iss , Pp 115132- (2023)
As a recognized endocrine disruptor in the environment targeting estrogen receptors (ERs), Bisphenol A (BPA) and its bisphenol S (BPS) analogs are involved in the development of breast cancer. Epigenetic modifications are crucial in many biological p
Externí odkaz:
https://doaj.org/article/c9fd9d3f772b43da834d1ff2c6c05246
Akademický článek
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Akademický článek
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Autor:
Qiao Li, Qingsan Zhu
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)- and α-ketoglutarate-dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of a variety of substrates, including DNA, RNA, and histones. Methylation is one
Externí odkaz:
https://doaj.org/article/82bcdd06973b414ba1649da77f7bdb1c