Zobrazeno 1 - 10
of 93
pro vyhledávání: '"histone deacetylases (HDAC)"'
Autor:
Yasuteru Inoue, Yingxue Ren, Shuwen Zhang, Michael Bamkole, Naeyma N. Islam, Manikandan Selvaraj, Wenyan Lu, Thomas R. Caulfield, Yonghe Li, Takahisa Kanekiyo
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
The maturation of brain microvascular endothelial cells leads to the formation of a tightly sealed monolayer, known as the blood–brain barrier (BBB). The BBB damage is associated with the pathogenesis of age-related neurodegenerative diseases inclu
Externí odkaz:
https://doaj.org/article/044332bc5f914607b440f788e2c9c05e
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Epigenetic mechanisms are involved in several cellular functions, and their role in the immune system is of prime importance. Histone deacetylases (HDACs) are an important set of enzymes that regulate and catalyze the deacetylation process. HDACs hav
Externí odkaz:
https://doaj.org/article/63fe3c1da11e4af6a8b738aec4216eb7
Autor:
Emre F. Bülbül, Dina Robaa, Ping Sun, Fereshteh Mahmoudi, Jelena Melesina, Matthes Zessin, Mike Schutkowski, Wolfgang Sippl
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 968 (2023)
Histone deacetylases (HDAC) represent promising epigenetic targets for several diseases including different cancer types. The HDAC inhibitors approved to date are pan-HDAC inhibitors and most show a poor selectivity profile, side effects, and in part
Externí odkaz:
https://doaj.org/article/e3586201481146dc87ec379763db81a5
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Histone deacetylases comprise a family of 18 genes, and classical HDACs are a promising class of novel anticancer drug targets. However, to date, no systematic study has been comprehensive to reveal the potential significance of these 18 genes in lun
Externí odkaz:
https://doaj.org/article/b2816a1d54f04ea2b89a344c321dc353
Publikováno v:
Asian-Australasian Journal of Animal Sciences, Vol 33, Iss 6, Pp 1023-1033 (2020)
Objective The efficiency of the knock-in process is very important to successful gene editing in domestic animals. Recently, it was reported that transient loosening of the nucleosomal folding of transcriptionally inactive chromatin might have the po
Externí odkaz:
https://doaj.org/article/46c2593c3d034297bfd9b611ee6a137b
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Akademický článek
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Autor:
Jôsimar D. Moreira, Bjørn E. V. Koch, Suzanne van Veen, Kimberley V. Walburg, Frank Vrieling, Tânia Mara Pinto Dabés Guimarães, Annemarie H. Meijer, Herman P. Spaink, Tom H. M. Ottenhoff, Mariëlle C. Haks, Matthias T. Heemskerk
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The rapid and persistent increase of drug-resistant Mycobacterium tuberculosis (Mtb) infections poses increasing global problems in combatting tuberculosis (TB), prompting for the development of alternative strategies including host-directed therapy
Externí odkaz:
https://doaj.org/article/93cd73d2210e45b7a7c55d02fa7a7a33
Autor:
Jyothi Dhuguru, Ola A. Ghoneim
Publikováno v:
Molecules, Vol 27, Iss 7, p 2294 (2022)
Cancer is the most devastating disease and second leading cause of death around the world. Despite scientific advancements in the diagnosis and treatment of cancer which can include targeted therapy, chemotherapy, endocrine therapy, immunotherapy, ra
Externí odkaz:
https://doaj.org/article/0bba851a35544599961ec3844c0bd59d