Zobrazeno 1 - 10
of 12 080
pro vyhledávání: '"histone deacetylase inhibitor"'
Autor:
Jieping Lin, Zicong Huang, Zihong Cai, Jia Li, Zhen Li, Chenhao Ding, Zhixiang Wang, Xiaofang Li, Xuan Zhou, Bailin He, Wenhao Zhong, Li Xuan, Qifa Liu, Yang Xu, Hongsheng Zhou
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract Early T-cell precursor lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) is a distinct subtype of T-ALL/LBL, characterized by a poor response to initial chemotherapy, a high relapse rate, and an inferior outcome. The treatment options for ETP-AL
Externí odkaz:
https://doaj.org/article/8af16b506c4b44ed9dfd1932f46c90d0
Publikováno v:
Cancer Management and Research, Vol Volume 16, Pp 855-869 (2024)
Markus Joerger,1 Kira-Lee Koster,1 Tomas Janik,2 Floris A de Jong3,4 1Department of Medical Oncology and Hematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland; 2Research & Development Department, Mundipharma Research Limited, Cambridge, U
Externí odkaz:
https://doaj.org/article/c54fad9cb73b45debd211cdd21d2c10a
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-20 (2024)
Abstract Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of various malignancies and have garnered attention as a viable target for therapeutic intervention. A variety of HDAC inhibitors (HDACis) have been deve
Externí odkaz:
https://doaj.org/article/d9a261daa6cb42d2b649425d48e72d24
Autor:
Stephen G. Smoots, Anna R. Schreiber, Marilyn M. Jackson, Stacey M. Bagby, Adrian T A. Dominguez, Evan D. Dus, Cameron A. Binns, Morgan MacBeth, Phaedra A. Whitty, Jennifer R. Diamond, Todd M. Pitts
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-13 (2024)
Abstract Background Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with a poor prognosis. Doxorubicin is part of standard curative therapy for TNBC, but chemotherapy resistance remains an important clinical challenge. Boc
Externí odkaz:
https://doaj.org/article/e983610b7e904575a33047cfca75f04a
Akademický článek
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Autor:
Kyra Parker, Yanfeng Zhang, Gavin Anchondo, Ashlyn Smith, Sergio Guerrero Pacheco, Tadashi Kondo, Le Su
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The SS18-SSX fusion protein is an oncogenic driver in synovial sarcoma. At the molecular level, SS18-SSX functions as both an activator and a repressor to coordinate transcription of different genes responsible for tumorigenesis. Here, we identify th
Externí odkaz:
https://doaj.org/article/3649b9f35f3b4e67807c6c0cb07b8882
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Histone deacetylases (HDAC) catalyze the removal of acetylation modifications on histones and non-histone proteins, which regulates gene expression and other cellular processes. HDAC inhibitors (HDACi), approved anti-cancer agents, emerge as a potent
Externí odkaz:
https://doaj.org/article/449d7c1e967a438984bbbcc079b04ab2
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 947-955 (2024)
Xue-Mei Liu,1,2,* Liu Yang,1,2,* Qi-Bin Yang1 1Department of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, 637000, People’s Republic of China; 2Department of Clinical Medicine
Externí odkaz:
https://doaj.org/article/acdc966286154bd1ba9be97d40276af1
Autor:
Kaoutar Bentayebi, Keittisak Suwan, Azzedine Ibrahimi, Louati Sara, Mouna Ouadghiri, Tarik Aanniz, Saaïd Amzazi, Lahcen Belyamani, Amin Hajitou, Rachid Eljaoudi
Publikováno v:
Brain Disorders, Vol 13, Iss , Pp 100113- (2024)
Diffuse intrinsic pontine glioma (DIPG) also referred as paediatric high-grade glioma (pHGG) is a fast-growing and aggressive type of childhood brain cancer. Recent studies investigating the molecular pathogenesis of DIPG have identified new therapeu
Externí odkaz:
https://doaj.org/article/2354290142a34e50bd0c2e747106451a
Autor:
Joana Grand-Guillaume, Rosalba Mansi, Raghuvir H. Gaonkar, Sandra Zanger, Melpomeni Fani, Philippe J. Eugster, Maja Beck Popovic, Eric Grouzmann, Karim Abid
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-20 (2023)
Abstract Background Neuroblastoma (NB) and pheochromocytoma/paraganglioma (PHEO/PGL) are neuroendocrine tumors. Imaging of these neoplasms is performed by scintigraphy after injection of radiolabeled meta-iodobenzylguanidine (mIBG), a norepinephrine
Externí odkaz:
https://doaj.org/article/d02749981c7d40669065e704f066964b