Zobrazeno 1 - 10
of 985
pro vyhledávání: '"histone deacetylase (HDAC)"'
Autor:
Wenying Yu, Jiajia Wang, Meiduo Wang, Gaolong Wen, Jiayan Liang, Xiaoting Chen, Guodong Lu, Zonghua Wang, Jun Huang
Publikováno v:
Agronomy, Vol 14, Iss 10, p 2196 (2024)
Transcriptional regulation mediated by the balance of histone acetylation and deacetylation is fundamental in responding to environmental cues by impacting chromatin remodeling. Histone deacetylases (HDACs) are enzymes that remove acetyl groups from
Externí odkaz:
https://doaj.org/article/cd6bb566cbfe4e37afcf946e3d737244
Autor:
Elena Mariotto, Martina Canton, Chiara Marchioro, Andrea Brancale, Ernest Hamel, Katia Varani, Fabrizio Vincenzi, Tiziano De Ventura, Chiara Padroni, Giampietro Viola, Romeo Romagnoli
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7519 (2024)
Because of synergism between tubulin and HDAC inhibitors, we used the pharmacophore fusion strategy to generate potential tubulin–HDAC dual inhibitors. Drug design was based on the introduction of a N-hydroxyacrylamide or a N-hydroxypropiolamide at
Externí odkaz:
https://doaj.org/article/1e5ac161f11043a0953566f7f8829ff5
Autor:
Jung-Chun Chu, Hui-Ju Tseng, Sung-Bau Lee, Kai-Cheng Hsu, Ling-Wei Hsin, Ru-Hao Liang, Tony Eight Lin, Nain-Chu Gao, Liang-Chieh Chen, Wan-Hsun Lu, Andrew H.-J Wang, Wei-Jan Huang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Class II histone deacetylases (HDACs) are considered as potential targets to treat Alzheimer’s disease (AD). Previously, C-3 substituted phenothiazine-containing compounds with class II HDAC-inhibiting activities was found to promote neurite outgro
Externí odkaz:
https://doaj.org/article/7b58580986544041963eeb2da4256825
Autor:
Hastono Ridwansyah, Indra Wijaya, Muhammad Hasan Bashari, Achmad Hussein Sundawa Kartamihardja, Bethy Suryawathy Hernowo
Publikováno v:
Biomolecules & Biomedicine, Vol 23, Iss 5 (2023)
B-cell non-Hodgkin lymphoma (B-NHL) is a lymphoid malignancy derived from B-cells that remains difficult to treat. Moreover, relapses and refractory cases are common. Abnormalities in epigenetic mechanisms, such as imbalanced histone acetylation affe
Externí odkaz:
https://doaj.org/article/dfe1cb5784014dff8c4998ed01a9e092
Publikováno v:
Guoji Yanke Zazhi, Vol 23, Iss 2, Pp 193-197 (2023)
AIM: To elucidate the effect of histone deacetylase(HDAC)inhibitor suberoylanilide hydroxamic acid(SAHA)on the proliferation of choroidal melanoma(CM)cell line C918 and to explore the related mechanism.METHODS: Inverted fluorescence microscope was us
Externí odkaz:
https://doaj.org/article/021270f807c84e28a0936439d671b0a9
Publikováno v:
Plants, Vol 13, Iss 5, p 580 (2024)
Salvia miltiorrhiza is a plant commonly used in traditional Chinese medicine. Its material bases for treating diseases are tanshinones and phenolic acids, including salvianolic acids. Histone deacetylase proteins (HDACs) are a class of specific funct
Externí odkaz:
https://doaj.org/article/e81a30e2f5064827938eacdea64932d9
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Akademický článek
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Autor:
Xianjun Xiao, Xiaoshen Hu, Junpeng Yao, Wei Cao, Zihao Zou, Lu Wang, Haiyan Qin, Dongling Zhong, Yuxi Li, Peiwen Xue, Rongjiang Jin, Ying Li, Yunzhou Shi, Juan Li
Publikováno v:
Frontiers in Microbiology, Vol 13 (2023)
Short-chain fatty acids (SCFAs) are metabolites of gut microbes that can modulate the host inflammatory response, and contribute to health and homeostasis. Since the introduction of the gut-skin axis concept, the link between SCFAs and inflammatory s
Externí odkaz:
https://doaj.org/article/ca5575c22f134c2a925b83822838efb0