The pharmacoepigenetic paradigm in cancer treatment

Autor: Belén Ocaña-Paredes, Sebastián Rivera-Orellana, David Ramírez-Sánchez, Juliana Montalvo-Guerrero, María Paula Freire, Samantha Espinoza-Ferrao, Adriana Altamirano-Colina, Paulina Echeverría-Espinoza, María José Ramos-Medina, Gabriela Echeverría-Garcés, Danilo Granda-Moncayo, Andrea Jácome-Alvarado, María Gabriela Andrade, Andrés López-Cortés

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

Epigenetic modifications, characterized by changes in gene expression without altering the DNA sequence, play a crucial role in the development and progression of cancer by significantly influencing gene activity and cellular function. This insight h

Externí odkaz: https://doaj.org/article/6aeb0f23da1d4129ad4c7d906668331a

Regulation of Thermogenic Adipocyte Differentiation and Adaptive Thermogenesis Through Histone Acetylation

Autor: Belinda X. Ong, Reinhard Brunmeir, Qiongyi Zhang, Xu Peng, Muhammad Idris, Chungang Liu, Feng Xu

Publikováno v: Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 11 (2020)

Over the past decade, the increasing prevalence of obesity and its associated metabolic disorders constitutes one of the most concerning healthcare issues for countries worldwide. In an effort to curb the increased mortality and morbidity derived fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58de013eea312c149ed2364d06317ad

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Quinoline-Based p300 Histone Acetyltransferase Inhibitors with Pro-apoptotic Activity in Human Leukemia U937 Cells

Autor: Rosaria Benedetti, Simone Carradori, Gianluca Sbardella, Alessia Lenoci, Stefano Tomassi, Lucia Altucci, Ettore Novellino, Veronica Rodriguez, Antonello Mai, Patrizia Filetici, Daniela Secci, Sabrina Castellano, Mariarosaria Conte, Dante Rotili

Publikováno v: ChemMedChem; Vol 9
ChemMedChem
9 (2014): 542–548. doi:10.1002/cmdc.201300536
info:cnr-pdr/source/autori:Lenoci, Alessia; Tomassi, Stefano; Conte, Mariarosaria; Benedetti, Rosaria; Rodriguez, Veronica; Carradori, Simone; Secci, Daniela; Castellano, Sabrina; Sbardella, Gianluca; Filetici, Patrizia; Novellino, Ettore; Altucci, Lucia; Rotili, Dante; Mai, Antonello/titolo:Quinoline-Based p300 Histone Acetyltransferase Inhibitors with Pro-apoptotic Activity in Human Leukemia U937 Cells/doi:10.1002%2Fcmdc.201300536/rivista:ChemMedChem (Print)/anno:2014/pagina_da:542/pagina_a:548/intervallo_pagine:542–548/volume:9

Chemical manipulations performed on 2-methyl-3-carbethoxyquinoline (1), a histone acetyltransferase inhibitor previously identified by our research group and active at the sub-millimolar/millimolar level, led to compounds bearing higher alkyl groups

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d0c1205b687286f4be043530b4beb1
http://hdl.handle.net/11386/4273853