The α4 Nicotinic Acetylcholine Receptor Is Necessary for the Initiation of Organophosphate-Induced Neuronal Hyperexcitability

Autor: Peter M. Andrew, Wei Feng, Jonas J. Calsbeek, Shane P. Antrobus, Gennady A. Cherednychenko, Jeremy A. MacMahon, Pedro N. Bernardino, Xiuzhen Liu, Danielle J. Harvey, Pamela J. Lein, Isaac N. Pessah

Publikováno v: Toxics, Vol 12, Iss 4, p 263 (2024)

Acute intoxication with organophosphorus (OP) cholinesterase inhibitors can produce seizures that rapidly progress to life-threatening status epilepticus. Significant research effort has been focused on investigating the involvement of muscarinic ace

Externí odkaz: https://doaj.org/article/7fb803086fdf4bbcb9efc66337280bca

Living-Neuron-Based Autogenerator

Autor: Svetlana A. Gerasimova, Anna Beltyukova, Anastasia Fedulina, Maria Matveeva, Albina V. Lebedeva, Alexander N. Pisarchik

Publikováno v: Sensors, Vol 23, Iss 16, p 7016 (2023)

We present a novel closed-loop system designed to integrate biological and artificial neurons of the oscillatory type into a unified circuit. The system comprises an electronic circuit based on the FitzHugh-Nagumo model, which provides stimulation to

Externí odkaz: https://doaj.org/article/df71321357e84ec1898652df2fbb8f99

Contribution of ginsenosides Rg1, Rb1 to the neuroprotective effect of Panax notoginseng in mouse organotypic hippocampal slice cultures exposed to oxygen and glucose deprivation

Autor: Nguyen Thi Thanh Loan, Le Thi Xoan, Pham Thi Nguyet Hang, Nguyen Van Tai

Publikováno v: Vietnam Journal of Science, Technology and Engineering, Vol 63, Iss 2 (2022)

We previously demonstrated that Panax notoginseng (pNG) root extract treatments exerted neuroprotective effects on brain injuries using middle cerebral artery occlusion in mice. The present study aims to investigate the neuroprotective effects of PNG

Externí odkaz: https://doaj.org/article/8c5ad0cf363e4545be76c8318e28abfc

Stimulation induces gradual increases in the thickness and curvature of postsynaptic density of hippocampal CA1 neurons in slice cultures

Autor: Jung-Hwa Tao-Cheng

Publikováno v: Molecular Brain, Vol 12, Iss 1, Pp 1-10 (2019)

Abstract Activity can induce structural changes in glutamatergic excitatory synapses, including increase in thickness and curvature of the postsynaptic density (PSD); these structural changes can only be documented by electron microscopy. Here in org

Externí odkaz: https://doaj.org/article/cfac13e4c7a34c418ba3796713df602d

Amyloid-beta treated organotypic hippocampal slices as a model system of Alzheimer´s disease

Autor: Lindgren, Sara Krogtoft

Publikováno v: Lindgren, Sara Krogtoft. Amyloid-beta treated organotypic hippocampal slices as a model system of Alzheimer´s disease. Master thesis, University of Oslo, 2022

Externí odkaz: http://hdl.handle.net/10852/95452
https://www.duo.uio.no/bitstream/handle/10852/95452/8/SKL-master-thesis.pdf