Zobrazeno 1 - 10
of 2 049
pro vyhledávání: '"hippocampal neuron"'
Autor:
Xiyue Yang, Fang Chu, Zhe Jiao, Hao Yu, Wenjing Yang, Yang Li, Chunqing Lu, Hao Ma, Sheng Wang, Zhipeng Liu, Shaoxiao Qin, Hongna Sun
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 283, Iss , Pp 116833- (2024)
Arsenic, a neurotoxic metalloid, poses significant health risks. However, ellagic acid, renowned for its antioxidant properties, has shown potential in neuroprotection. This study aimed to investigate the neuroprotective effects of ellagic acid again
Externí odkaz:
https://doaj.org/article/1eea01b048a94c67ac06778ca5d4ab75
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 281, Iss , Pp 116674- (2024)
The persistence of the novel brominated flame retardant, bis(2-ethylhexyl)-3,4,5,6-tetrabromophthalate (TBPH), in the environment and its potential for bioaccumulation in living organisms, including humans, further exacerbate its health risks. Theref
Externí odkaz:
https://doaj.org/article/450231d15751405e8b4a6ed2978cbedc
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Endoplasmic reticulum-associated degradation (ERAD) is a principal quality-control mechanism responsible for targeting misfolded ER proteins for cytosolic degradation. Evidence suggests that impairment of ERAD contributes to neuron dysfunction and de
Externí odkaz:
https://doaj.org/article/705f78595b444a46b9b6e46e423b4f60
Autor:
Pengzhan Zhao, Wenqian Shi, Yangfan Ye, Ke Xu, Jingming Hu, Honglu Chao, ZeQiang Tao, Lei Xu, Wei Gu, Liuchao Zhang, Tian Wang, Xinyue Wang, Jing Ji
Publikováno v:
Redox Biology, Vol 72, Iss , Pp 103156- (2024)
Regulation of the oxidative stress response is crucial for the management and prognosis of traumatic brain injury (TBI). The copper chaperone Antioxidant 1 (Atox1) plays a crucial role in regulating intracellular copper ion balance and impacting the
Externí odkaz:
https://doaj.org/article/5121d69de8624704abbae0747a2cbaec
Publikováno v:
Animal Cells and Systems, Vol 27, Iss 1, Pp 436-446 (2023)
ABSTRACTDopamine (DA) plays a significant role in regulating hippocampal function, particularly in modulating synaptic plasticity. Despite this, a comprehensive understanding of the molecular mechanisms involved in neuroplasticity-related signaling i
Externí odkaz:
https://doaj.org/article/1e2f5fa7d1834232990b1373fe774933
Publikováno v:
环境与职业医学, Vol 40, Iss 4, Pp 441-447 (2023)
BackgroundBenzo[a]pyrene (BaP) is neurotoxic and can cause neuronal damage by oxidative stress. Proanthocyanidin (PC) has antioxidant activity, and its mechanism may related to nuclear factor-erythroid 2-related factor 2 (Nrf2)-heme oxygenase-1 (HO-1
Externí odkaz:
https://doaj.org/article/841bc550d7274cb592507819da4fcfed
Publikováno v:
环境与职业医学, Vol 40, Iss 4, Pp 433-440 (2023)
BackgroundBenzo[a]pyrene (BaP) has neurotoxicity, which can induce the loss of hippocampal neurons in humans and animals and lead to spatial learning and memory dysfunction, but its mechanism is still unclear. ObjectiveTo observe the ferroptosis of m
Externí odkaz:
https://doaj.org/article/f4406a3d3f0e408fac7c8047058e5e44
Autor:
Guoqing Wu, Yanyan Wu
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 5, Pp n/a-n/a (2023)
Abstract The hippocampus has been implicated in the pathogenesis of insomnia disorder (ID) and the purpose of this study was to investigate the neuroprotective mechanism of the natural flavone Kurarinone (Kur) on hippocampal neurotoxicity as a potent
Externí odkaz:
https://doaj.org/article/22c8d7a68d134e38828c248b07867754
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
The lysosomal protein TMEM106B was identified as a risk modifier of multiple dementias including frontotemporal dementia and Alzheimer’s disease. The gene comes in two major haplotypes, one associated with disease risk, and by comparison, the other
Externí odkaz:
https://doaj.org/article/ac3f8cd9009243edb4a2e96bbb2cac97
Autor:
Qing Tao, Di Yang, Kunpeng Qin, Lei Liu, Mengmeng Jin, Famin Zhang, Jinjin Zhu, Jie Wang, Qingli Luo, Jian Du, Li Yu, Jilong Shen, Deyong Chu
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-19 (2023)
Abstract Background Alzheimer's disease presents an abnormal cognitive behavior. TgCtwh6 is one of the predominant T. gondii strains prevalent in China. Although T. gondii type II strain infection can cause host cognitive behavioral abnormalities, we
Externí odkaz:
https://doaj.org/article/b68daf67763f4bbcba411de12b00de28