Zobrazeno 1 - 10
of 1 543
pro vyhledávání: '"higher-order structure"'
Autor:
Bo Zhao, Joy Yoon, Bojie Zhang, Youmi Moon, Yue Fu, Yinyin Li, Yunlong Zhao, Hui Xiao, Ning Li
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Methionine oxidation can substantially alter the structure and functionality of monoclonal antibodies (mAbs), especially when it occurs in the complementarity-determining regions (CDRs). It is imperative to fully understand the effects of methionine
Externí odkaz:
https://doaj.org/article/1ec92c06f523461786a1034aaa3d9648
Autor:
Yutaro Ibi, Ryuichi Nishinakamura
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 4, Pp 151450- (2024)
Over the past decade, the induction protocols for the two types of kidney organoids (nephron organoids and ureteric bud organoids) from pluripotent stem cells (PSCs) have been established based on the knowledge gained in developmental nephrology. Kid
Externí odkaz:
https://doaj.org/article/2e73dfc65caa4464838434f14f19f21c
Autor:
Mingyue Li, Victor A. Beaumont, Shahajahan Akbar, Hannah Duncan, Arch Creasy, Wenge Wang, Kelly Sackett, Lisa Marzilli, Jason C. Rouse, Hai-Young Kim
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
The higher order structure (HOS) of monoclonal antibodies (mAbs) is an important quality attribute with strong contribution to clinically relevant biological functions and drug safety. Due to the multi-faceted nature of HOS, the synergy of multiple c
Externí odkaz:
https://doaj.org/article/c60148f3693e491c9f2b5b111def14a8
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 14, Iss 8, Pp 100966- (2024)
Biotherapeutic's higher order structure (HOS) is a critical determinant of its functional properties and conformational relevance. Here, we evaluated two covalent labeling methods: diethylpyrocarbonate (DEPC)-labeling and fast photooxidation of prote
Externí odkaz:
https://doaj.org/article/8af40caf50274687a4fde890db80b3b3
Autor:
Tomohiko Ikeda, Yuki Yamaguchi, Hiroaki Oyama, Aoba Matsushita, Yasuo Tsunaka, Mitsuko Fukuhara, Tetsuo Torisu, Susumu Uchiyama
Publikováno v:
Viruses, Vol 16, Iss 4, p 585 (2024)
The higher-order structure (HOS) is a critical quality attribute of recombinant adeno-associated viruses (rAAVs). Evaluating the HOS of the entire rAAV capsid is challenging because of the flexibility and/or less folded nature of the VP1 unique (VP1u
Externí odkaz:
https://doaj.org/article/4f0dadd2c7e44ce585495c7697d86bf6
Autor:
Tsega L. Solomon, Frank Delaglio, John P. Giddens, John P. Marino, Yihua Bruce Yu, Marc B. Taraban, Robert G. Brinson
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThe clinical efficacy and safety of protein-based drugs such as monoclonal antibodies (mAbs) rely on the integrity of the protein higher order structure (HOS) during product development, manufacturing, storage, and patient administration. As
Externí odkaz:
https://doaj.org/article/bb46764035b14affa365dc495b827f5d
Publikováno v:
Entropy, Vol 26, Iss 3, p 248 (2024)
Diverse higher-order structures, foundational for supporting a network’s “meta-functions”, play a vital role in structure, functionality, and the emergence of complex dynamics. Nevertheless, the problem of dismantling them has been consistently
Externí odkaz:
https://doaj.org/article/28a61d2723144e79ad0893d8c11f900f
Publikováno v:
New Journal of Physics, Vol 26, Iss 1, p 013027 (2024)
Most existing random network models that describe complex systems in nature and society are developed through connections that indicate a binary relationship between two nodes. However, real-world networks are so complicated that we can only identify
Externí odkaz:
https://doaj.org/article/4029721104764fd8b135669e2cc6bc79
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Akademický článek
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