Výsledky vyhledávání - "higher-order drug combination analysis"

Akademický článek

COMBImage2: a parallel computational framework for higher-order drug combination analysis that includes automated plate design, matched filter based object counting and temporal data mining

Autor: Efthymia Chantzi, Malin Jarvius, Mia Niklasson, Anna Segerman, Mats G. Gustafsson

Publikováno v: BMC Bioinformatics, Vol 20, Iss 1, Pp 1-20 (2019)

Abstract Background Pharmacological treatment of complex diseases using more than two drugs is commonplace in the clinic due to better efficacy, decreased toxicity and reduced risk for developing resistance. However, many of these higher-order treatm

Externí odkaz: https://doaj.org/article/78835e3f27a44e85bc329afc1f788729

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Algorithmic discovery, development and personalized selection of higher-order drug cocktails : A label-free live-cell imaging & secretomics approach

Autor: Chantzi, Efthymia

An upward trend in clinical pharmacology is the use of multiple drugs to combat complex and co-occurring diseases due to better efficacy, decreased toxicity and reduced risk of evolving resistance. Despite high late-stage attrition rates and the need

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b3ae0cf650815a923ea33289a967dbd1
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-408613

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COMBSecretomics : a pragmatic methodological framework for higher-order drug combination analysis using secretomics

Autor: Mats G. Gustafsson, Efthymia Chantzi, Michael Neidlin, Leonidas G. Alexopoulos, George Macheras

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0232989 (2020)
PLoS ONE

Multi drug treatments are increasingly used in the clinic to combat complex and co-occurring diseases. However, most drug combination discovery efforts today are mainly focused on anticancer therapy and rarely examine the potential of using more than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4feb37ee2f7d956e514785a67dfcba
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-408607

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COMBImage2: a parallel computational framework for higher-order drug combination analysis that includes automated plate design, matched filter based object counting and temporal data mining

Autor: Malin Jarvius, Mats G. Gustafsson, Efthymia Chantzi, Anna Segerman, Mia Niklasson

Publikováno v: BMC Bioinformatics
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-20 (2019)

Background Pharmacological treatment of complex diseases using more than two drugs is commonplace in the clinic due to better efficacy, decreased toxicity and reduced risk for developing resistance. However, many of these higher-order treatments have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bae59f13c46ca98397d24c078bf7b0c
https://pubmed.ncbi.nlm.nih.gov/31164078

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