Zobrazeno 1 - 10
of 908
pro vyhledávání: '"high-throughput screening (HTS)"'
Autor:
Mei Li, Zhu-Chun Bei, Yongtian Yuan, Baogang Wang, Dongna Zhang, Likun Xu, Liangliang Zhao, Qin Xu, Yabin Song
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Papain-like protease (PLpro) is an attractive anti-coronavirus target. The development of PLpro inhibitors, however, is hampered by the limitations of the existing PLpro assay and the scarcity of validated active compounds. We developed a novel in-ce
Externí odkaz:
https://doaj.org/article/5a01b9e861734741bbb82b9fba6c65f7
Autor:
Thomas A. Mackenzie, José R. Tormo, Bastien Cautain, Germán Martínez, Isabel Sánchez, Olga Genilloud, Francisca Vicente, Maria C. Ramos
Publikováno v:
SLAS Technology, Vol 29, Iss 3, Pp 100111- (2024)
Natural Products (NPs) are one of the main sources for drug discovery. Many clinical drugs are NPs or NP-inspired compounds, and recently discovered New Chemical Entities (NCEs) of NPs are emerging as promising new drugs. High-Throughput Screening (H
Externí odkaz:
https://doaj.org/article/8fd4b72cc19c459ea5afb4fb95a2858d
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Externí odkaz:
https://doaj.org/article/c2dab91b3959449c94cfaf652789a345
Autor:
Sang-Yun Lee, Hyeong Jun Cho, Jimin Choi, Bosung Ku, Seok Whan Moon, Mi Hyoung Moon, Kyung Soo Kim, Kwanyong Hyun, Tae-Jung Kim, Yeoun Eun Sung, Yongki Hwang, Eunyoung Lee, Dong Hyuck Ahn, Joon Young Choi, Jeong Uk Lim, Chan Kwon Park, Sung Won Kim, Seung Joon Kim, In-Seong Koo, Woo Seok Jung, Sang-Hyun Lee, Chang Dong Yeo, Dong Woo Lee
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)
Abstract Background Recently, cancer organoid-based drug sensitivity tests have been studied to predict patient responses to anticancer drugs. The area under curve (AUC) or IC50 value of the dose-response curve (DRC) is used to differentiate between
Externí odkaz:
https://doaj.org/article/1e7aa84956254a19be5701f8b97f3b4d
Publikováno v:
Frontiers in Medicine, Vol 10 (2024)
IntroductionTolerogenic Dendritic Cells (tolDCs) have an exceptional promise as a potential therapy for autoimmune disease and transplantation rejection. TolDCs are a unique phenotype of antigen presenting cells (APCs) that can influence naïve T cel
Externí odkaz:
https://doaj.org/article/80ffa3c819714175acc7500a2de58a0d
Autor:
Xinyang Liu, Jiao Liu, Zhemin Liu, Qianqian Qiao, Xiaomeng Ni, Jinxing Yang, Guannan Sun, Fanghe Li, Wenjuan Zhou, Xuan Guo, Jiuzhou Chen, Shiru Jia, Yu Zheng, Ping Zheng, Jibin Sun
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2024)
Allosteric regulation by pathway products plays a vital role in amino acid metabolism. Homoserine dehydrogenase (HSD), the key enzyme for the biosynthesis of various aspartate family amino acids, is subject to feedback inhibition by l-threonine and l
Externí odkaz:
https://doaj.org/article/494f5fb264df49a28c51892a9c96dad8
Publikováno v:
Biosensors, Vol 14, Iss 6, p 275 (2024)
Human sulfotransferase 1As (hSULT1As) play a crucial role in the metabolic clearance and detoxification of a diverse range of endogenous and exogenous substances, as well as in the bioactivation of some procarcinogens and promutagens. Pharmacological
Externí odkaz:
https://doaj.org/article/a97b5e6ec82f4b29a8e950b54a1b118d
Publikováno v:
SLAS Discovery, Vol 27, Iss 6, Pp 369-374 (2022)
Rapid triage of compounds acting via undesired mechanisms is a crucial stage in a high-throughput screening (HTS) cascade to ensure time and resource is efficiently assigned to the most propitious hits. Redox cycling compounds (RCCs) produce reactive
Externí odkaz:
https://doaj.org/article/d115c57880dc46a8866e862a75ba2730
Akademický článek
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Autor:
Corinne Molyneux, Ian Sinclair, Helen L. Lightfoot, Jarrod Walsh, Geoffrey A. Holdgate, Rachel Moore
Publikováno v:
SLAS Discovery, Vol 27, Iss 5, Pp 323-329 (2022)
Large compound libraries utilised for HTS often include metal contaminated compounds which can interfere with assay signal or target biology, and therefore appear as hits. Pursuit of these compounds can divert considerable time and resource away from
Externí odkaz:
https://doaj.org/article/ed06f33c492f44088699aae3902bc583