Zobrazeno 1 - 10
of 1 691
pro vyhledávání: '"high throughput screen"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/021e2398fda34b1ea384a91ca242b133
Autor:
Daniel H. Call, John Asafo Adjei, Ryan Pilgrim, James W. Jeong, E. Vance Willis, Ronald A. Zegarra, Nicholas L. Tapia, Madalyn Osterhaus, Jacob A. Vance, Charles M. Voyton, James A. Call, Sabrina S. Pizarro, James C. Morris, Kenneth A. Christensen
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 26, Iss , Pp 100557- (2024)
Kinetoplastid organisms, including Trypanosoma brucei, are a significant health burden in many tropical and semitropical countries. Much of their metabolism is poorly understood. To better study kinetoplastid metabolism, chemical probes that inhibit
Externí odkaz:
https://doaj.org/article/e34558ac362a47d9bc034f7935e262a8
Autor:
Jenna S. Bleloch, Sizhu Lu, Saif Feroz Khan, Karabo Serala, Elena Seraia, Val Millar, Daniel Ebner, Colin Goding, Sharon Prince
Publikováno v:
Cancer Medicine, Vol 13, Iss 19, Pp n/a-n/a (2024)
ABSTRACT Background The highly homologous T‐box transcription factors TBX2 and TBX3 are critical for embryonic development, and their overexpression in postnatal tissues contributes to a wide range of malignancies, including melanoma and rhabdomyos
Externí odkaz:
https://doaj.org/article/b05b7595e6f146efa5ddf6599544d343
Autor:
Qin, Song-Kang a, b, 1, Li, Kuan-Hao a, 1, Liu, Ben-Jin a, 1, Cao, Cun a, Yu, De-Bin a, Jiang, Zhi-Gang a, Wang, Jun a, Han, Yu-Xin a, Wang, Fang a, Qi, Ying-Lin a, Sun, Chao a, Yu, Li a, Chang, Ji-Tao a, c, ⁎, Yin, Xin a, ⁎
Publikováno v:
In Virologica Sinica December 2024 39(6):917-928
Autor:
Marta Kazimierska, Marta Podralska, Magdalena Żurawek, Tomasz Woźniak, Marta Elżbieta Kasprzyk, Weronika Sura, Wojciech Łosiewski, Iwona Ziółkowska‐Suchanek, Joost Kluiver, Anke van denBerg, Natalia Rozwadowska, Agnieszka Dzikiewicz‐Krawczyk
Publikováno v:
Molecular Oncology, Vol 17, Iss 11, Pp 2295-2313 (2023)
The transcription factor MYC is a proto‐oncogene with a well‐documented essential role in the pathogenesis and maintenance of several types of cancer. MYC binds to specific E‐box sequences in the genome to regulate gene expression in a cell‐t
Externí odkaz:
https://doaj.org/article/3bbbce64088f40e599bd9a4c360ff540
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101349- (2024)
Phospholipase D3 (PLD3) and D4 (PLD4) are endolysosomal exonucleases of ssDNA and ssRNA that regulate innate immunity. Polymorphisms of these enzymes are correlated with numerous human diseases, including Alzheimer’s, rheumatoid arthritis, and syst
Externí odkaz:
https://doaj.org/article/cc3b7d81355b40c5bcdbda876efff1c1
Autor:
Shabir Hassan, Museer A. Lone
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/9ac3fedca04941d1a4eec802f12ca1c9
Autor:
Lanxin Zhang, Hexin Li, Jingchao Liu, Gaoyuan Sun, Xiaokun Tang, Siyuan Xu, Lili Zhang, Wei Zhang, Bin Ai
Publikováno v:
Cancer Medicine, Vol 12, Iss 8, Pp 9815-9825 (2023)
Abstract Immune checkpoints are protein molecules expressed on the immune cell membrane, which regulate the immune system to kill tumor cells. As an essential immune checkpoint, overexpressed PD‐1 on tumor cells could inhibit T‐cell activation af
Externí odkaz:
https://doaj.org/article/c1d60e7154104c459fe0c9b071df07cb
Autor:
Lidor David, Etai Shpigel, Itay Levin, Shaked Moshe, Lior Zimmerman, Shilat Dadon-Simanowitz, Benjamin Shemer, Shon A. Levkovich, Liraz Larush, Shlomo Magdassi, Shimshon Belkin
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4252-4260 (2023)
We present a methodology for a high-throughput screening (HTS) of transcription factor libraries, based on bacterial cells and GFP fluorescence. The method is demonstrated on the Escherichia coli LysR-type transcriptional regulator YhaJ, a key elemen
Externí odkaz:
https://doaj.org/article/0202fd52c6be4f228b21da7bb4159a17
Autor:
Saira R. Ali, Karen J. Humphreys, Kaylene.J. Simpson, Ross A. McKinnon, Robyn Meech, Michael Z. Michael
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 30-47 (2022)
The gut fermentation product butyrate displays anti-cancer properties in the human proximal colon, including the ability to inhibit proliferation and induce apoptosis in colorectal cancer (CRC) cells. A natural histone deacetylase inhibitor (HDACi),
Externí odkaz:
https://doaj.org/article/c9d3f06c95044ce5a87a26b56e3eec3e