Zobrazeno 1 - 10
of 1 525
pro vyhledávání: '"high grade serous ovarian cancer"'
Autor:
Annapoorna Venkatachalam, Cristina Correia, Kevin L. Peterson, Xianon Hou, Paula A. Schneider, Annabella R. Strathman, Karen S. Flatten, Chance C. Sine, Emily A. Balczewski, Cordelia D. McGehee, Melissa C. Larson, Laura N. Duffield, X. Wei Meng, Nicole D. Vincelette, Husheng Ding, Ann L. Oberg, Fergus J. Couch, Elizabeth M. Swisher, Hu Li, S. John Weroha, Scott H. Kaufmann
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Recent studies indicate that replication checkpoint modulators (RCMs) such as inhibitors of CHK1, ATR, and WEE1 have promising monotherapy activity in solid tumors, including platinum-resistant high grade serous ovarian cancer (HGSOC). Howev
Externí odkaz:
https://doaj.org/article/10416db1db3e4dd388e15b58bcaf44a8
Autor:
G. V. Zhukova, E. P. Ulyanova, A. P. Menshenina, T. I. Moiseenko, E. Yu. Zlatnik, E. M. Nepomnyashchaya, A. B. Sagakyants, E. V. Verenikina
Publikováno v:
Сибирский онкологический журнал, Vol 23, Iss 4, Pp 45-53 (2024)
The aim of the study was to evaluate a prognostic significance of immunohistochemical parameters in serous ovarian carcinomas and their statistical relationships after neoadjuvant treatment to assess the development of tumor resistance to platinum-co
Externí odkaz:
https://doaj.org/article/16577991c9404cefa3d2b666045ff7b7
Autor:
Julia McAdams, Jasmine Ebott, Corinne Jansen, Chloe Kim, Daniela Maiz, Joyce Ou, Linda C. Hanley, Payton De La Cruz, Nicole E. James
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-12 (2024)
Abstract Background High grade serous ovarian cancer (HGSOC) is the most lethal gynecologic malignancy in which patients have still yet to respond meaningfully to clinically available immunotherapies. Hence, novel immune targets are urgently needed.
Externí odkaz:
https://doaj.org/article/31699427513a4cbe853e00abe9374970
Autor:
Anna Røssberg Lauridsen, Aikaterini Skorda, Nuggi Ingholt Winther, Marie Lund Bay, Tuula Kallunki
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Cholesterol homeostasis is essential for healthy mammalian cells and dysregulation of cholesterol metabolism contributes to the pathogenesis of various diseases including cancer. Cancer cells are dependent on cholesterol. Malignant progressi
Externí odkaz:
https://doaj.org/article/511b1c286d194328b2120c7ccb6c05dd
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-21 (2024)
Abstract Background High-grade serous ovarian cancer (HGSOC), which is known for its heterogeneity, high recurrence rate, and metastasis, is often diagnosed after being dispersed in several sites, with about 80% of patients experiencing recurrence. D
Externí odkaz:
https://doaj.org/article/ada281d7158342069aea4fc13e5a9c29
Autor:
Olivier Romito, Aude Lemettre, Aurélie Chantôme, Ophélie Champion, Noémie Couty, Lobna Ouldamer, Nadine Hempel, Mohamed Trebak, Caroline Goupille, Marie Potier‐Cartereau
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 1853-1865 (2024)
No data are currently available on the functional role of small conductance Ca2+‐activated K+ channels (SKCa) in ovarian cancer. Here, we characterized the role of SK2 (KCa2.2) in ovarian cancer cell migration and chemosensitivity. Using the select
Externí odkaz:
https://doaj.org/article/9b4055aa053c49139808a9db354ee945
Autor:
Siddik Sarkar, Sarbar Ali Saha, Abhishek Swarnakar, Arnab Chakrabarty, Avipsa Dey, Poulomi Sarkar, Sarthak Banerjee, Pralay Mitra
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Background The clinicopathological parameters such as residual tumor, grade, the International Federation of Gynecology and Obstetrics (FIGO) score are often used to predict the survival of ovarian cancer patients, but the 5-year survival of
Externí odkaz:
https://doaj.org/article/4a1c6d2d9e854181a6669a73477e9229
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract High-grade serous ovarian cancer (HGSOC) is an aggressive disease known to develop resistance to chemotherapy. We investigated the prognostic significance of tumor cell states and potential mechanisms underlying chemotherapy resistance in HG
Externí odkaz:
https://doaj.org/article/78d65755c77d44379061dc2ced776990
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundHypoxia is significantly associated with cancer progression and treatment outcomes. Nevertheless, the precise molecular mechanisms underlying the hypoxia-induced immunosuppressive microenvironment in high-grade serous ovarian cancer (HGSOC)
Externí odkaz:
https://doaj.org/article/0c56ade5b0b347299af0fb3a3183a633
Publikováno v:
Heliyon, Vol 10, Iss 20, Pp e38888- (2024)
The 5-year survival rate for ovarian cancer has remained relatively static over the past number of years, which can be attributed in part to the lack of new therapeutic strategies to target this disease. Although numerous other cancer types have bene
Externí odkaz:
https://doaj.org/article/d7329195a1bc46559218c1ab097a87f6