Zobrazeno 1 - 10
of 32 968
pro vyhledávání: '"high‐grade"'
Autor:
Pinar Cakmak, Philipp Jurmeister, Iris Divé, Pia S. Zeiner, Joachim P. Steinbach, Tim R. Fenton, Karl H. Plate, Marcus Czabanka, Patrick N. Harter, Katharina J. Weber
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Giant cell (gc)-enriched glioblastoma (gcGB) represents a distinct histological variant of isocitrate dehydrogenase wild-type adult-type glioblastoma with notable enlarged mono- or multinuclear tumor cells. While some studies sugg
Externí odkaz:
https://doaj.org/article/8526f144477745d7a6ce35afef5ef37a
Autor:
Kaylin M. Carey, Corey D. Young, Alexis J. Clark, Eric B. Dammer, Rajesh Singh, James W. Lillard
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-18 (2024)
Abstract High-grade serous ovarian cancer (HGSOC) is marked by significant molecular diversity, presenting a major clinical challenge due to its aggressive nature and poor prognosis. This study aims to deepen the understanding of HGSOC by characteriz
Externí odkaz:
https://doaj.org/article/481b6655b9ed4a5fb5eafbc237cd95de
Mathematical modeling framework enhances clinical trial design for maintenance treatment in oncology
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Clinical trials are costly and time-intensive endeavors, with a high rate of drug candidate failures. Moreover, the standard approaches often evaluate drugs under a limited number of protocols. In oncology, where multiple treatment protocols
Externí odkaz:
https://doaj.org/article/6fe6f374bc144e598dd2f09fb985c6f3
Autor:
Bardia Hajikarimloo, Mohammad Amin Habibi, Alireza Kooshki, Mohammadamin Sabbagh Alvani, Amir Hossein Zare, Arman Hasanzade, Amir Hessam Zare, Mohammadhosein Akhlaghpasand, Roozbeh Tavanaei, Salem M. Tos
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Dabrafenib plus trametinib is a novel targeted therapy for low-grade (LGG) and high-grade (HGG) gliomas. This systematic review and meta-analysis aimed to evaluate the safety and efficacy of dabrafenib plus trametinib in LGG and H
Externí odkaz:
https://doaj.org/article/ae1b93b1da7b40659136ab18db03b129
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract The objective of this prospective study was to assess the efficacy of Hiporfin-photodynamic therapy (PDT) int the treatment of young women diagnosed with high-grade squamous intraepithelial lesions (HSIL) of the endocervical canal. This stud
Externí odkaz:
https://doaj.org/article/0287e45e361d4726834c08f79e6b454a
Autor:
Laurel K. Berry, Ashok K. Pullikuth, Kristen L. Stearns, Yuezhu Wang, Calvin J. Wagner, Jeff W. Chou, Janelle P. Darby, Michael G. Kelly, Raghvendra Mall, Ming Leung, Julia Chifman, Lance D. Miller
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background While high-grade serous ovarian cancer (HGSC) has proven largely resistant to immunotherapy, sporadic incidents of partial and complete response have been observed in clinical trials and case reports. These observations suggest th
Externí odkaz:
https://doaj.org/article/2a89f06ac496454988bc1743ae9d8592
Autor:
Aideen McCabe, Gerard P. Quinn, Suneil Jain, Micheál Ó Dálaigh, Kellie Dean, Ross G. Murphy, Simon S. McDade
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Advances in transcriptional profiling methods have enabled the discovery of molecular subtypes within and across traditional tissue-based cancer classifications. Such molecular subgroups hold potential for improving patient outcom
Externí odkaz:
https://doaj.org/article/6bf7d15909354ee88385117df5f155c1
Autor:
Arnault Tauziède-Espariat, Lea L. Friker, Gunther Nussbaumer, Brigitte Bison, Volodia Dangouloff-Ros, Alice Métais, David Sumerauer, Josef Zamecnik, Martin Benesch, Thomas Perwein, Dannis van Vuurden, Pieter Wesseling, Andrés Morales La Madrid, Maria Luisa Garrè, Manila Antonelli, Felice Giangaspero, Torsten Pietsch, Dominik Sturm, David T. W. Jones, Stefan M. Pfister, Yura Grabovska, Alan Mackay, Chris Jones, Jacques Grill, Yassine Ajlil, André O. von Bueren, Michael Karremann, Marion Hoffmann, Christof M. Kramm, Robert Kwiecien, David Castel, Gerrit H. Gielen, Pascale Varlet
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract Diffuse pediatric-type high-grade gliomas (pedHGG), H3- and IDH-wildtype, encompass three main DNA-methylation-based subtypes: pedHGG-MYCN, pedHGG-RTK1A/B/C, and pedHGG-RTK2A/B. Since their first description in 2017 tumors of pedHGG-RTK2A/B
Externí odkaz:
https://doaj.org/article/a314c4fae9f64dd98df77f621bcc505c
Publikováno v:
Cancer Management and Research, Vol Volume 16, Pp 1617-1626 (2024)
Xuexue Bai,1 Hao Xing,1 Ming Feng,1 Wenbin Ma,1 Shiyong Wang2 1Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People’s Republic of China; 2Department
Externí odkaz:
https://doaj.org/article/7d39029f8cc74a36b6d37d52c6121fd4
Autor:
Yu Liu, Ruizhen Li, Changzhong Li, Zhihong Liu, Lvfang Duan, Qianyu Huang, Lina Geng, Jun Hou, Lihui Wei, Ruifang Wu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The study aimed to compare the effectiveness between Hiporfin-photodynamic therapy (PDT) and loop electrosurgical excision procedure (LEEP) in treating cervical high-grade squamous intraepithelial lesion (HSIL). We conducted a retrospective
Externí odkaz:
https://doaj.org/article/0845bb0ade8c48679a74a8f4a89268af