Zobrazeno 1 - 10
of 2 950
pro vyhledávání: '"hif1a"'
Autor:
Jong Ho Chun, Kotohiko Kimura, Monika Rajput, Ming-Hua Hsu, Yu-Chuan Liang, Akanksha Ramadas Shanbhag, Pei-Ju Chiang, Tiffany L. B. Jackson, Ru Chih C. Huang
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 11, Pp 12481-12496 (2024)
This study provides evidence to support the concept proposed by Kimura et al. in 2023 that the inhibitors of SP1, MYC, and HIF1A should induce strong anticancer activity by reducing the expression of stem cell-related proteins. In LN229 and U87MG gli
Externí odkaz:
https://doaj.org/article/d5d99a88227645108d9da8421cf23d20
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-12 (2024)
Abstract Metformin, a widely used anti-diabetic agent, has shown significant anti-cancer properties as reported in in various cancers, including acute myeloid leukemia. However, the detailed mechanisms by which metformin influences acute myeloid leuk
Externí odkaz:
https://doaj.org/article/a7b4416de3db4afe975faea52644bfbd
Autor:
Huijie Zhao, Xing Wu, Yinghan Wang, Xiuling Li, Yuhui Du, Zhiqing Zhou, Yu Li, Yue Liu, Xiaofei Zeng, Guoan Chen
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background A growing body of evidence indicates that histone variants play an oncogenic role in cancer progression. However, the role and mechanism of histone variant H2AZ1 in lung cancer remain poorly understood. In this study, we aim to id
Externí odkaz:
https://doaj.org/article/8139edbb24c140fa897346c9631bc652
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-12 (2024)
Abstract Ovarian cancer is an extremely malignant gynaecological tumour with a poor patient prognosis and is often associated with chemoresistance. Thus, exploring new therapeutic approaches to improving tumour chemosensitivity is important. The expr
Externí odkaz:
https://doaj.org/article/be53e7bc0bfc4e008f5f6f7633f52758
Autor:
Jinru Cui, Heli Li, Cong Hu, Feiyan Zhang, Yunjie Li, Ying Weng, Liping Yang, Yingying Li, Minglan Yao, Hao Li, Xiaoping Luo, Yan Hao
Publikováno v:
Neurobiology of Disease, Vol 204, Iss , Pp 106763- (2025)
Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a high social burden and limited treatments. Hypoxic condition of the brain is considered an important pathological mechanism of ASD. HIF1A is a key participant in brain
Externí odkaz:
https://doaj.org/article/3e7c818102344c44b19ebcea73a725d3
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-4 (2024)
Abstract With great interest, we have read the recent article “Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery” published by Lyu et al. in Annals of the Rheumatic Dis
Externí odkaz:
https://doaj.org/article/4f9ef201e7504681b3f9d058752051d1
Autor:
Seungyoon Nam, Yeeun Lee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract To elucidate the correlation of HIF1A with clinicopathologic characteristics in patients with gastric cancer (GC), we conducted a systematic review and meta-analysis. We searched PubMed, Embase and Web of Science for studies on GC and HIF1A,
Externí odkaz:
https://doaj.org/article/6c15b51c8dec489aaeb5efcbfe1532b1
Autor:
Chuncheng Liu, Gehui Liu, Xinyang Zuo, Donghui Qu, Yefeng Sun, Linan Liu, Xiujuan Zhao, Jun Li, Lu Cai
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Hypoxia can cause a variety of diseases, including ischemic stroke and neurodegenerative diseases. Within a certain range of partial pressure of oxygen, cells can respond to changes in oxygen. Changes in oxygen concentration beyond a thresho
Externí odkaz:
https://doaj.org/article/063b014f9ed44f58aa4b3cff02b523a1
Autor:
Cui, Jinru a, 1, Li, Heli a, 1, Hu, Cong a, Zhang, Feiyan a, Li, Yunjie a, Weng, Ying b, Yang, Liping a, Li, Yingying b, Yao, Minglan b, Li, Hao c, Luo, Xiaoping b, Hao, Yan a, ⁎
Publikováno v:
In Neurobiology of Disease January 2025 204
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37584- (2024)
Background: Tinnitus treatment remains a global challenge, and current therapeutic approaches are still controversial. This study aims to elucidate the potential mechanisms of Xiao-Chai-Hu-Tang (XCHT) in treating tinnitus through the analysis of netw
Externí odkaz:
https://doaj.org/article/73bbef22678b41d4bc3783d280dfb83b