Zobrazeno 1 - 10
of 9 468
pro vyhledávání: '"hif"'
Autor:
Lei Yang, Jiawen Shi, Mingyang Zhong, Pingping Sun, Xiaojing Zhang, Zhengyi Lian, Hang Yin, Lijun Xu, Guyin He, Haiyan Xu, Han Wu, Ziheng Wang, Kai Miao, Jianfei Huang
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-22 (2024)
Abstract Objective Colorectal cancer (CRC) is a form of malignancy that exhibits a comparatively elevated occurrence and fatality rate. Given the relatively slower progress in diagnostic and therapeutic approaches for CRC, there is a need to investig
Externí odkaz:
https://doaj.org/article/f6089bb2051847afab42d9c82d2d5e9d
Autor:
Dezhi Wang, Heng Zhang, Xingchen Liao, Jun Li, Jie Zeng, Yilin Wang, Mingjie Zhang, Xianzong Ma, Xin Wang, Fangli Ren, Yinyin Wang, Meng Li, Junfeng Xu, Peng Jin, Jianqiu Sheng
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract The prevention and treatment of gastrointestinal mucosal injury caused by a plateau hypoxic environment is a clinical conundrum due to the unclear mechanism of this syndrome; however, oxidative stress and microbiota dysbiosis may be involved
Externí odkaz:
https://doaj.org/article/5cbfe8acffb146058f5e6d16188ca57d
Akademický článek
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Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 6, Pp 702-712 (2024)
Objective·To investigate the biological roles and associated mechanisms of the hypoxia-induced long non-coding RNA 68 (HILRNA68) in hepatocellular carcinoma (HCC) cell lines.Methods·Long non-coding RNA (lncRNA) microarray analysis was conducted to
Externí odkaz:
https://doaj.org/article/44ca7943559c48668f7dca2e08ddc360
Publikováno v:
Oxygen, Vol 4, Iss 2, Pp 236-252 (2024)
Uterine fibroids are the most common tumors in females, affecting up to 70% of women worldwide, yet targeted therapeutic options are limited. Oxidative stress has recently surfaced as a key driver of fibroid pathogenesis and provides insights into hy
Externí odkaz:
https://doaj.org/article/f27603264178488891e265d6d6ce8e88
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Hypoxia-inducible factors (HIF) 1 and 2 regulate similar but distinct sets of target genes. Although HIFs are best known for their roles in mediating the hypoxia response accumulating evidence suggests that under certain conditions HIFs, par
Externí odkaz:
https://doaj.org/article/29a0acf166bb48f285af62d95f03f260
Autor:
Ping Zhao, Xing-Bo He, Xin-Yue Chen, Zhang-Long Li, Wen-Jia Xing, Wei Liu, Cong Ren, Xu-Dong Han, Bin Guo
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Objective Melanoma, with its high degree of malignancy, stands as one of the most dangerous skin cancers and remains the primary cause of death from skin cancer. With studies demonstrating the potential of traditional Chinese medicine to int
Externí odkaz:
https://doaj.org/article/f37f2abb61a44b089f76cc9d4c931b50
Publikováno v:
Frontiers in Nephrology, Vol 4 (2024)
Desidustat is a small molecule inhibitor of hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) discovered and developed by Zydus Lifesciences for the treatment of anemia associated with chronic kidney disease (CKD). This review summarizes the precl
Externí odkaz:
https://doaj.org/article/f87f64d3827a4fd490384c885aff0970
Autor:
Serina Kita, Hiroshi Okuyama, Takaya Kondo, Mizuki Hayashi, Shinichiro Nakao, Toshitaka Sawamura, Keiji Fujimoto, Atsushi Nakagawa, Hitoshi Yokoyama, Kengo Furuichi
Publikováno v:
Clinical Case Reports, Vol 12, Iss 9, Pp n/a-n/a (2024)
Key Clinical Message Recently, hypoxia‐inducible factor prolyl hydroxylase (HIF‐PH) inhibitors have been used for renal anemia, but side effects have also been reported. We report on the association of central hypothyroidism and cholesterol with
Externí odkaz:
https://doaj.org/article/a5ef3dbb553344b7bd9c71e7ed451220
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Ferroptosis is an iron-dependent form of cell death, which finally culminates in lipid peroxidation and membrane damage. During the past decade, the interest in ferroptosis increased substantially and various regulatory components were discovered. Th
Externí odkaz:
https://doaj.org/article/ab6f33bf92b249c7a681cc9fb5c1f723