Zobrazeno 1 - 10
of 1 306
pro vyhledávání: '"hiPSCs"'
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 11, Pp 565-579 (2024)
Abstract Transmembrane protein 182 (TMEM182) is notably abundant in muscle and adipose tissue, but its role in the heart remains unknown. This study examined the contribution of TMEM182 in the differentiation of human induced pluripotent stem cells (
Externí odkaz:
https://doaj.org/article/e59bcd8fe5bd4b7fb5909f743039f676
The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage quality
Autor:
Ghazaleh Hajmousa, Rodrigo Coutinho de Almeida, Niek Bloks, Alejandro Rodríguez Ruiz, Marga Bouma, Roderick Slieker, Thomas B. Kuipers, Rob G. H. H. Nelissen, Keita Ito, Christian Freund, Yolande F. M. Ramos, Ingrid Meulenbelt
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Lack of insight into factors that determine purity and quality of human iPSC (hiPSC)-derived neo-cartilage precludes applications of this powerful technology toward regenerative solutions in the clinical setting. Here, we set out
Externí odkaz:
https://doaj.org/article/8bd8407590d1416185cae1f298cdadb2
Autor:
Adrian Pragiwaksana, Muhammad Irsyad, Muhammad Hanif Nadhif, Akhmadu Muradi, Chyntia Olivia Maurine Jasirwan, Vetnizah Juniantito, Ridho Ardhi Syaiful, Radiana Dhewayani Antarianto
Publikováno v:
International Journal of Technology, Vol 15, Iss 5, Pp 1203-1217 (2024)
In clinical terms, end-stage liver disease is a group of liver diseases that includes advanced liver disease, liver failure, and decompensated cirrhosis. Liver transplantation has been the most effective treatment for cirrhosis. The limited numbe
Externí odkaz:
https://doaj.org/article/fb4a784e78aa4c839924735050324611
Autor:
Chunwen Duan, Chengcheng Ding, Xihao Sun, Shengru Mao, Yuqin Liang, Xinyu Liu, Xiaoyan Ding, Jiansu Chen, Shibo Tang
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background X-linked juvenile retinoschisis (XLRS) is an inherited disease caused by RS1 gene mutation, which leads to retinal splitting and visual impairment. The mechanism of RS1-associated retinal degeneration is not fully understood. Besi
Externí odkaz:
https://doaj.org/article/ba74c82df0bc43448614ae57b83e48c7
Autor:
Zuzanna Kuczynska, Pawan Kumar Neglur, Erkan Metin, Michal Liput, Marzena Zychowicz, Valery Zayat, Natalia E. Krześniak, Leonora Buzanska, Marta Kot
Publikováno v:
Folia Neuropathologica, Vol 62, Iss 1, Pp 32-46 (2024)
Human induced pluripotent stem cells (hiPSCs) are a potential source of somatic cells for cell therapies due to their ability to self-renew and differentiate into various cells of the body. To date, the clinical application of hiPSCs has been limited
Externí odkaz:
https://doaj.org/article/4753d037bcb6466b862fca68646726d5
Autor:
Shouhai Wu, Cuiping Rong, Ruishan Lin, Kaiyuan Ji, Tongxiang Lin, Weimin Chen, Wei Mao, Yang Xu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundPaBing-II Formula (PB-II) is a traditional Chinese medicine for treating Parkinson’s disease (PD). However, owing to the complexity of PB-II and the difficulty in obtaining human dopaminergic neurons (DAn), the mechanism of action of PB-I
Externí odkaz:
https://doaj.org/article/153f9207006b4ae0969a684d734cb4ca
Autor:
Burak Ozgür, Elena Puris, Andreas Brachner, Antje Appelt-Menzel, Sabrina Oerter, Viktor Balzer, Mikkel Roland Holst, Rasmus Folmann Christiansen, Kathrine Hyldig, Stephen T. Buckley, Mie Kristensen, Seppo Auriola, Allan Jensen, Gert Fricker, Morten Schallburg Nielsen, Winfried Neuhaus, Birger Brodin
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Background Blood-brain barrier (BBB) models based on primary murine, bovine, and porcine brain capillary endothelial cell cultures have long been regarded as robust models with appropriate properties to examine the functional transport of sm
Externí odkaz:
https://doaj.org/article/a725aae18819471b8862ddc5715b995e
Autor:
Mengqi Jiang, Yuanxiu Song, Xi Chen, Wenjing Lu, Min Zhu, Mingyu Wei, Feng Lan, Ming Cui, Yun Bai
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background Cardiac remodeling is the initiating factor for the development of heart failure, which can result from various cardiomyopathies. Cytochrome c oxidase subunit 6A2 (COX6A2) is one of the components of cytochrome c oxidase that driv
Externí odkaz:
https://doaj.org/article/67d26bab091e482f8f835679e04964ca
Autor:
Virginia Deidda, Isabel Ventisette, Marianna Langione, Lucrezia Giammarino, Josè Manuel Pioner, Caterina Credi, Federico Carpi
Publikováno v:
Journal of Functional Biomaterials, Vol 15, Iss 10, p 297 (2024)
We describe the development of a bioink to bioprint human induced pluripotent stem cells (hiPSCs) for possible cardiac tissue engineering using a gelatin methacrylate (GelMA)-based hydrogel. While previous studies have shown that GelMA at a low conce
Externí odkaz:
https://doaj.org/article/8b1cf18b086f4e8cbe3056a0ee3f6ede
Publikováno v:
Genes and Diseases, Vol 10, Iss 5, Pp 2151-2166 (2023)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have attracted attention in the field of regenerative medicine due to their potential ability to repair damaged hearts. However, the immature phenotype of these cells limits their
Externí odkaz:
https://doaj.org/article/ed52fc8c95c34a11931994ba9da70c4e