Zobrazeno 1 - 10
of 2 898
pro vyhledávání: '"hiPSC"'
Autor:
Pedro Vicente, Joana I. Almeida, Inês E. Crespo, Nikolaus Virgolini, Inês A. Isidro, Maria Eréndira Calleja-Cervantes, Juan R. Rodriguez-Madoz, Felipe Prosper, Paula M. Alves, Margarida Serra
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Hepatocytes-like cells (HLC) derived from human induced pluripotent stem cells show great promise for cell-based liver therapies and disease modelling. However, their application is currently hindered by the low production yields of existing
Externí odkaz:
https://doaj.org/article/70c758a07bc245059b4c1832ecd92381
Autor:
Thomas Hutschalik, Ozan Özgül, Marilù Casini, Brigitta Szabó, Rémi Peyronnet, Óscar Bártulos, Mariana Argenziano, Ulrich Schotten, Elena Matsa
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Background Atrial fibrillation has an estimated prevalence of 1.5–2%, making it the most common cardiac arrhythmia. The processes that cause and sustain the disease are still not completely understood. An association between atrial fibrill
Externí odkaz:
https://doaj.org/article/62230f7377c342b9b213ccfb407b8704
Autor:
Doris Cerecedo
Publikováno v:
Mexican Journal of Medical Research ICSA, Vol 12, Iss 24, Pp 12-19 (2024)
In recent years, there has been a concerted effort to develop in vivo and ex vivo models that replicate the histology, physiology, and pathology of human airways, but their translation to human applications has posed significant challenges. Ethical c
Externí odkaz:
https://doaj.org/article/f10605ab00fe47f598c1c11d121c245c
Autor:
Jin Ye, Sichi Xu, Xiaoqing Liu, Qiyu Zhang, Xiao Li, Hui Zhang, Jie Ma, Ling Leng, Shuyang Zhang
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Abnormalities in T cell activation play an important role in the pathogenesis of myocarditis, and persistent T cell responses can lead to autoimmunity and chronic cardiac inflammation, as well as even dilated cardiomyopathy. Altho
Externí odkaz:
https://doaj.org/article/dcd9961c3e304bae99f1f777cae0d5e7
Autor:
Hengliang Zhang, Payel Sen, Jules Hamers, Theresa Sittig, Brent Woestenburg, Allessandra Moretti, Andreas Dendorfer, Daphne Merkus
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) by traditional methods are a mix of atrial and ventricular CMs and many other non-cardiomyocyte cells. Retinoic acid (RA) plays an important role in r
Externí odkaz:
https://doaj.org/article/236e8f7b4280464d849755516f0aea5b
Autor:
Mania Ackermann, Fawaz Saleh, Shifaa M. Abdin, Anna Rafiei Hashtchin, Ingrid Gensch, Julia Golgath, Marco Carvalho Oliveira, Ariane H. H. Nguyen, Svenja Gaedcke, Arno Fenske, Mi-Sun Jang, Adan C. Jirmo, Markus Abeln, Gesine Hansen, Nico Lachmann
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Background There is a significant demand for intermediate-scale bioreactors in academic and industrial institutions to produce cells for various applications in drug screening and/or cell therapy. However, the application of these bioreactor
Externí odkaz:
https://doaj.org/article/a386a9eed5a141dcb1f49f98b94c1d5f
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-27 (2024)
Abstract Background Variation in X chromosome inactivation (XCI) in human-induced pluripotent stem cells (hiPSCs) can impact their ability to model biological sex biases. The gene-wise landscape of X chromosome gene dosage remains unresolved in femal
Externí odkaz:
https://doaj.org/article/948460aec0694b3eb9427830f6390bc9
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Stem cell derived cardiac monolayers have high potential for tissue regeneration, in vitro drug testing and disease modeling. However, current differentiation protocols are still sub-optimal, resulting in cultures with variable yields and properties.
Externí odkaz:
https://doaj.org/article/0777a10dba114e3085013fe689624efb
Autor:
Swagata Ghatak, Jolene K. Diedrich, Maria Talantova, Nivedita Bhadra, Henry Scott, Meetal Sharma, Matthew Albertolle, Nicholas J. Schork, John R. Yates III, Stuart A. Lipton
Publikováno v:
Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)
Abstract Standard single‐cell (sc) proteomics of disease states inferred from multicellular organs or organoids cannot currently be related to single‐cell physiology. Here, a scPatch‐Clamp/Proteomics platform is developed on single neurons gene
Externí odkaz:
https://doaj.org/article/7f4dd02cff274168ba32976ec18c4157
Autor:
Shichen Wu, Junkai Xie, Han Zhao, Xihui Zhao, Oscar F. Sánchez, Jean-Christophe Rochet, Jennifer L. Freeman, Chongli Yuan
Publikováno v:
Environment International, Vol 190, Iss , Pp 108914- (2024)
PFOA is a legacy Per- and Polyfluorinated Substances (PFAS), a group of chemicals widely used in various industrial applications and consumer products. Although there has been a voluntary phase out of PFOA since 2005, it is still widely detected in v
Externí odkaz:
https://doaj.org/article/ff9ac210c41c4b7eb98c04a8a23fd177