Zobrazeno 1 - 10
of 1 106
pro vyhledávání: '"hereditary persistence"'
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Journal of Clinical and Diagnostic Research, Vol 16, Iss 8, Pp EC17-EC20 (2022)
Introduction: Childhood anaemia may be caused due to many factors, including malnutrition, chronic infections, deficiency of iron and vitamins, parasitic infections. On haematological work up the most common finding is microcytic hypochromic anaemia.
Externí odkaz:
https://doaj.org/article/4ad6a170e63749239fa7977d06734b2c
Autor:
Dian Lu, Zhiliang Xu, Zhiyong Peng, Yinghong Yang, Bing Song, Zeyu Xiong, Zhirui Ma, Hongmei Guan, Bangzhu Chen, Yukio Nakamura, Juan Zeng, Nengqing Liu, Xiaofang Sun, Diyu Chen
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Reactivation of γ-globin expression is a promising therapeutic approach for β-hemoglobinopathies. Here, we propose a novel Cas9/AAV6-mediated genome editing strategy for the treatment of β-thalassemia: Natural HPFH mutations −113A > G, −114C >
Externí odkaz:
https://doaj.org/article/9670f5472db7477fb9b99dfdbfa72249
Autor:
Petros Papadopoulos, Athanassia Kafasi, Iris M. De Cuyper, Vilma Barroca, Daniel Lewandowski, Zahra Kadri, Martijn Veldthuis, Jeffrey Berghuis, Nynke Gillemans, Celina María Benavente Cuesta, Frank G. Grosveld, Rob van Zwieten, Sjaak Philipsen, Muriel Vernet, Laura Gutiérrez, George P. Patrinos
Publikováno v:
Human Genomics, Vol 14, Iss 1, Pp 1-12 (2020)
Abstract The expression of the human β-like globin genes follows a well-orchestrated developmental pattern, undergoing two essential switches, the first one during the first weeks of gestation (ε to γ), and the second one during the perinatal peri
Externí odkaz:
https://doaj.org/article/ebde74cd3e4042dc96bb58a33041796f
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Clinical Case Reports, Vol 9, Iss 8, Pp n/a-n/a (2021)
Abstract Red blood cell exchange transfusion may be beneficial and should be considered in the early management of patients with sickle cell disease and COVID‐19 to prevent the need for intubation and intensive care unit admission due to respirator
Externí odkaz:
https://doaj.org/article/7f035610a40f404eb2ec4f89e7d4f1d3
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The expression of the fetal Gγ- and Aγ-globin genes in normal development is confined to the fetal period, where two γ-globin chains assemble with two α-globin chains to form α2γ2 tetramers (HbF). HbF sustains oxygen delivery to tissues until b
Externí odkaz:
https://doaj.org/article/0cf3b9fad4784341913f5580d207f332
Publikováno v:
Frontiers in Genome Editing, Vol 2 (2020)
Hemoglobin is a tetrameric protein composed of two α and two β chains, each containing a heme group that reversibly binds oxygen. The composition of hemoglobin changes during development in order to fulfill the need of the growing organism, stably
Externí odkaz:
https://doaj.org/article/25d029c2cac3430b813e898820df2e81
Autor:
Ha Ly Thi Thanh, Huong Le Thi Thanh, Long Hoang Luong, Thinh Huy Tran, Su-Ching Liu, Hai Nam Truong, Thanh Van Ta, The - Hung Bui, Van Khanh Tran
Publikováno v:
Taiwanese Journal of Obstetrics & Gynecology, Vol 57, Iss 3, Pp 435-441 (2018)
Objective: The thalassemias is a group of hereditary disorders with impaired production of functional hemoglobin. In this report we described a rare case of compound heterozygous mutation of South-East Asia type hereditary persistence of fetal hemogl
Externí odkaz:
https://doaj.org/article/eb1162ceafa8486f878114c421f0184d