Zobrazeno 1 - 10
of 1 682
pro vyhledávání: '"hepatocyte transplantation"'
Autor:
Huanxiao Shi, Yi Ding, Pingxin Sun, Zhuman Lv, Chunyan Wang, Haoxin Ma, Junyu Lu, Bing Yu, Wenlin Li, Chao Wang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Hepatocyte transplantation (HTx) has been a novel cell-based therapy for severe liver diseases, as the donor livers for orthotopic liver transplantation are of great shortage. However, HTx has been confronted with two main hurdles: limited high-quali
Externí odkaz:
https://doaj.org/article/c892df0b74a34371bbed213a34eb732b
Autor:
Guang-Peng Zhou, Shi-Peng Li, Yi-Zhou Jiang, Jie Sun, Yu-Le Tan, Zhi-Gui Zeng, Lin Wei, Wei Qu, Li-Ying Sun, Zhi-Jun Zhu
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Explanted livers from patients with inherited metabolic liver diseases possess the potential to be a cell source of good-quality hepatocytes for hepatocyte transplantation (HT). This study evaluated the therapeutic effects of domi
Externí odkaz:
https://doaj.org/article/4c5a378bd865462cb316c5ecc2458d3d
Autor:
Mengmeng Jiang, Ren Guo, Yan Ai, Gang Wang, Peilan Tang, Xiaohui Jia, Bingqing He, Qianting Yuan, Xin Xie
Publikováno v:
JHEP Reports, Vol 5, Iss 4, Pp 100670- (2023)
Background & Aims: Hepatocyte transplantation has emerged as a possible treatment option for end-stage liver disease. However, an important obstacle to therapeutic success is the low level of engraftment and proliferation of transplanted hepatocytes,
Externí odkaz:
https://doaj.org/article/e55970c4876343079e0fa3fa8dc3c020
Autor:
Yuki Tamaki, Yuria Shibata, Misaki Hayakawa, Nodoka Kato, Ami Machii, Yuma Ikeda, Eri Nanizawa, Yumi Hayashi, Hiroshi Suemizu, Hiroyasu Ito, Tetsuya Ishikawa
Publikováno v:
Biochemistry and Biophysics Reports, Vol 32, Iss , Pp 101382- (2022)
Background and Aim: Cell-based transplantation therapy using hepatocytes, hepatic stem cells, hepatocyte-like cells induced from stem cells, etc. is thought to be an attractive alternative to liver transplantation, and have been studied to date. For
Externí odkaz:
https://doaj.org/article/6d6075716f794eddb0303d4bc67f22e6
Autor:
Ranjeet S. Kalsi, Alina Ostrowska, Adam Olson, Mubina Quader, Melvin Deutsch, Norma J. Arbujas-Silva, Jen Symmonds, Alejandro Soto-Gutierrez, John J. Crowley, Miguel Reyes-Mugica, Giselle Sanchez-Guerrero, Hartmut Jaeschke, Bruce P. Amiot, Marilia Cascalho, Scott L. Nyberg, Jeffrey L. Platt, Edgar N. Tafaleng, Ira J. Fox
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Acute hepatic failure is associated with high morbidity and mortality for which the only definitive therapy is liver transplantation. Some fraction of those who undergo emergency transplantation have been shown to recover native liver function when t
Externí odkaz:
https://doaj.org/article/4a6dde84b6564e42889da8c6dbe04394
Akademický článek
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Autor:
İlgin Özden
Publikováno v:
Cam & Sakura Medical Journal, Vol 1, Iss 1, Pp 1-6 (2021)
Liver transplantation is a unique operation that has not only saved tens of thousands of lives directly, but has also led to dramatic developments in multiple fields of medicine other than surgery.
Externí odkaz:
https://doaj.org/article/31aaecd7df1e49bebc9492b00210b879
Autor:
Clara T. Nicolas, Robert A. Kaiser, Raymond D. Hickey, Kari L. Allen, Zeji Du, Caitlin J. VanLith, Rebekah M. Guthman, Bruce Amiot, Lukkana Suksanpaisan, Bing Han, Maria Giovanna Francipane, Amin Cheikhi, Huailei Jiang, Aditya Bansal, Mukesh K. Pandey, Ishan Garg, Val Lowe, Aditya Bhagwate, Daniel O’Brien, Jean-Pierre A. Kocher, Timothy R. DeGrado, Scott L. Nyberg, Eric Lagasse, Joseph B. Lillegard
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 738-750 (2020)
The effectiveness of cell-based therapies to treat liver failure is often limited by the diseased liver environment. Here, we provide preclinical proof of concept for hepatocyte transplantation into lymph nodes as a cure for liver failure in a large-
Externí odkaz:
https://doaj.org/article/8ffcb39c8aed4257acfa76228d16a408
Autor:
Srikumar Sengupta, Brian Johnson, Morten Seirup, Hamisha Ardalani, Bret Duffin, Gregory A. Barrett-Wilt, Ron Stewart, James A. Thomson
Publikováno v:
Current Research in Toxicology, Vol 1, Iss , Pp 70-84 (2020)
Derivation and culture of small hepatocyte progenitor cells (SHPCs) capable of proliferating in vitro has been described in rodents and recently in humans. These cells are capable of engrafting in injured livers, however, they display de-differentiat
Externí odkaz:
https://doaj.org/article/5d90f8b0ea054633a507cfb4f82e1185