Hepatocyte growth factor is upregulated in ischemic retina and contributes to retinal vascular leakage and neovascularization

Autor: Valeria E. Lorenc, Raquel Lima e Silva, Sean F. Hackett, Seth D. Fortmann, Yuanyuan Liu, Peter A. Campochiaro

Publikováno v: FASEB BioAdvances, Vol 2, Iss 4, Pp 219-233 (2020)

Abstract In patients with macular edema due to ischemic retinopathy, aqueous levels of hepatocyte growth factor (HGF) correlate with edema severity. We tested whether HGF expression and activity in mice with oxygen‐induced ischemic retinopathy supp

Externí odkaz: https://doaj.org/article/55eb1a2a210e42579ab4fb3a085186e8

Hepatocyte growth factor is upregulated in ischemic retina and contributes to retinal vascular leakage and neovascularization

Autor: Peter A. Campochiaro, Valeria E. Lorenc, Seth D. Fortmann, Sean F. Hackett, Yuanyuan Liu, Raquel Lima e Silva

Publikováno v: FASEB BioAdvances
FASEB BioAdvances, Vol 2, Iss 4, Pp 219-233 (2020)

In patients with macular edema due to ischemic retinopathy, aqueous levels of hepatocyte growth factor (HGF) correlate with edema severity. We tested whether HGF expression and activity in mice with oxygen‐induced ischemic retinopathy supports a ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b2b342a574242bfea2b380eb514f4b
https://doi.org/10.1096/fba.2019-00074

Posttranslational modifications of serine protease TMPRSS13 regulate zymogen activation, proteolytic activity, and cell surface localization

Autor: Fausto A. Varela, Kimberley E. Sala-Hamrick, Jacob R. Mackinder, Karin List, Andrew S. Murray, Carly E. Martin, Evan C. Harrison, Joseph G. Lundgren

Publikováno v: The Journal of Biological Chemistry

TMPRSS13, a member of the type II transmembrane serine protease (TTSP) family, harbors four N-linked glycosylation sites in its extracellular domain. Two of the glycosylated residues are located in the scavenger receptor cysteine-rich (SRCR) protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f496da9b03bc8b4f22e362d41f685527
http://europepmc.org/articles/PMC8503615

205-LB: HGFAC Is a ChREBP-Regulated Hepatokine That Enhances Glucose and Lipid Homeostasis

Autor: Wenxin Tong, Harini Srinivasan, Jonathan M. Haldeman, Linus Tsai, Ludivine Doridot, Ashot Sargsyan, Rachael Ivison, Sarah A. Hannou, Ruby Monn, Inna Astapova, Henry H. Kou, Mark A. Herman

Publikováno v: Diabetes. 70

Carbohydrate Responsive Element-Binding Protein (ChREBP) is a carbohydrate sensing transcription factor that regulates metabolic gene programs. Genetic variants in the ChREBP locus associate with diverse metabolic traits in humans, including circulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74dc81e09e00a34dfd8f8858cbf9e812
https://doi.org/10.2337/db21-205-lb

Inhibition of an active zymogen protease:the zymogen form of matriptase is regulated by HAI-1 and HAI-2

Autor: Lotte K. Vogel, Annika W. Nonboe, Cecilia C. Thomas, Lars Vitved, Ásdís K. Frost, Lasse Holt-Danborg, Signe Skovbjerg, Jan K. Jensen, Zebin Hong, Christine R. Schar

Publikováno v: Skovbjerg, S, Holt-Danborg, L, Nonboe, A W, Hong, Z, Frost, Á K, Schar, C R, Thomas, C C, Vitved, L, Jensen, J K & Vogel, L K 2020, ' Inhibition of an active zymogen protease : the zymogen form of matriptase is regulated by HAI-1 and HAI-2 ', The Biochemical journal, vol. 477, no. 9, pp. 1779-1794 . https://doi.org/10.1042/BCJ20200182

The membrane-bound serine protease matriptase belongs to a rare subset of serine proteases that display significant activity in the zymogen form. Matriptase is critically involved in epithelial differentiation and homeostasis, and insufficient regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b62bac235b7508cd90b4bebc7689f5c
https://pure.au.dk/portal/da/publications/inhibition-of-an-active-zymogen-protease(c1e131da-975e-4df8-a670-6db09d2af227).html