Zobrazeno 1 - 10
of 1 035
pro vyhledávání: '"hepatocyte differentiation"'
Autor:
Pedro Vicente, Joana I. Almeida, Inês E. Crespo, Nikolaus Virgolini, Inês A. Isidro, Maria Eréndira Calleja-Cervantes, Juan R. Rodriguez-Madoz, Felipe Prosper, Paula M. Alves, Margarida Serra
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Hepatocytes-like cells (HLC) derived from human induced pluripotent stem cells show great promise for cell-based liver therapies and disease modelling. However, their application is currently hindered by the low production yields of existing
Externí odkaz:
https://doaj.org/article/70c758a07bc245059b4c1832ecd92381
Autor:
Chie Naito, Karis Kosar, Eriko Kishimoto, Loren Pena, Yilun Huang, Kaili Hao, Anas Bernieh, Jennifer Kasten, Chet Villa, Priya Kishnani, Bali Deeksha, Mingxia Gu, Akihiro Asai
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 39, Iss , Pp 101069- (2024)
Background: Glycogen Storage disease type 4 (GSD4), a rare disease caused by glycogen branching enzyme 1 (GBE1) deficiency, affects multiple organ systems including the muscles, liver, heart, and central nervous system. Here we report a GSD4 patient,
Externí odkaz:
https://doaj.org/article/60fc31d9dbb348cd85f5493e6acaff31
Autor:
Junbo Liang, Jinsong Wei, Jun Cao, Jun Qian, Ran Gao, Xiaoyu Li, Dingding Wang, Yani Gu, Lei Dong, Jia Yu, Bing Zhao, Xiaoyue Wang
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-27 (2023)
Abstract Background Harnessing hepatocytes for basic research and regenerative medicine demands a complete understanding of the genetic determinants underlying hepatocyte differentiation and maturation. Single-cell CRISPR screens in organoids could l
Externí odkaz:
https://doaj.org/article/5f3ca2b9dda84d65adf459b5225d1307
Publikováno v:
Bioactive Materials, Vol 28, Iss , Pp 50-60 (2023)
As the most abundant liver-specific microRNA, microRNA-122 (miR122) played a crucial role in the differentiation of stem cells into hepatocytes. However, highly efficient miR122 delivery still confronts challenges including poor cellular uptake and e
Externí odkaz:
https://doaj.org/article/9e76809b783e420ab3a40c44d22700c6
Autor:
Marino Caruso, Sébastien Meurant, Damien Detraux, Amandine Mathieu, Manon Gilson, Marc Dieu, Antoine Fattaccioli, Catherine Demazy, Mustapha Najimi, Etienne Sokal, Thierry Arnould, Catherine Verfaillie, Denis L.J. Lafontaine, Patricia Renard
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 254-268 (2023)
Summary: Translational regulation is of paramount importance for proteome remodeling during stem cell differentiation at both the global and the transcript-specific levels. In this study, we characterized translational remodeling during hepatogenic d
Externí odkaz:
https://doaj.org/article/ee12d780943e4a26ba8afbf1d2114e94
Akademický článek
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Akademický článek
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Akademický článek
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Publikováno v:
Data in Brief, Vol 43, Iss , Pp 108477- (2022)
A variety of methods have been reported for the differentiation of hepatocyte-like cells (HLCs) from human induced pluripotent stem cells (iPSCs) using various growth factors or small molecules. However, direct comparison of the differentiation effic
Externí odkaz:
https://doaj.org/article/b0e2bb96cef748b19502b9342df535ef
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-21 (2020)
Abstract Background Hepatocyte-like cells (HLCs) derived from human induced pluripotent stem cells (iPSCs) hold great promise in toxicological applications as well as in regenerative medicine. Previous efforts on hepatocyte differentiation have mostl
Externí odkaz:
https://doaj.org/article/050a29d497e046bcbda45ab772adde80