Zobrazeno 1 - 10
of 7 219
pro vyhledávání: '"hepatocarcinogenesis"'
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e32848- (2024)
Background: Hepatocellular carcinoma (HCC) is one of the most prevalent primary liver carcinoma. Guanine nucleotide-binding protein, α-activating activity polypeptide O (GNAO1) was reported to be under-expressed in HCC tissues. This study aimed to i
Externí odkaz:
https://doaj.org/article/a5555faeec96475690c4a904a76477fd
Autor:
Diego Samuel Rodrigues, Guilherme Augusto Soares, Verónica Andréa González-López, Anibal Thiago Bezerra, Mats Jirstrand, José Ricardo de Arruda Miranda
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S27- (2024)
Introduction/Justification: Magnetic nanoparticles (MNPs) have been explored as a new potential theranostic agent, and several studies have devoted significant efforts to employ MNPs in biomedicine, including their applications as imaging contrast ag
Externí odkaz:
https://doaj.org/article/cf72e896efad41018673df76a779ef58
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background N6-methyladenosine (m6A) is the most prevalent RNA modification. Although hnRNPA2B1, as a reader of m6A modification, has been reported to promote tumorigenesis in a few types of tumors, its role in hepatocellular carcinoma (HCC)
Externí odkaz:
https://doaj.org/article/bbf0ff64e7e9448bb1da64db08ff4a54
Autor:
Anindita Banerjee, Patrizia Farci
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8641 (2024)
The liver is a complex organ that performs vital functions in the body. Despite its extraordinary regenerative capacity compared to other organs, exposure to chemical, infectious, metabolic and immunologic insults and toxins renders the liver vulnera
Externí odkaz:
https://doaj.org/article/dd9962e6efd445fa99aa6dee05d69aad
Autor:
Daisuke Taguchi, Yohei Shirakami, Hiroyasu Sakai, Toshihide Maeda, Takao Miwa, Masaya Kubota, Kenji Imai, Takashi Ibuka, Masahito Shimizu
Publikováno v:
Nutrients, Vol 16, Iss 15, p 2506 (2024)
More effective treatments for hepatitis viral infections have led to a reduction in the incidence of liver cirrhosis. A high-fat diet can lead to chronic hepatitis and liver fibrosis, but the effects of lipid intake on liver disease status, including
Externí odkaz:
https://doaj.org/article/f060dc5f03f04940b68bd1ce2a4e9e0c
Publikováno v:
Plants, Vol 13, Iss 14, p 1975 (2024)
2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC) is a major compound in Cleistocalyx nervosum seed extract (CSE), which has been reported to have various biological activities, including anti-cancer activity. Therefore, this study at
Externí odkaz:
https://doaj.org/article/3466c81a8ab34080a53ff127ca5ccf1f
Autor:
Meiyu Shao, Yifan Wang, Hongyan Dong, Lu Wang, Xiaoqing Zhang, Xin Han, Xianan Sang, Yini Bao, Mengyun Peng, Gang Cao
Publikováno v:
Bioactive Materials, Vol 23, Iss , Pp 187-205 (2023)
Liver fibrosis and hepatocellular carcinoma (HCC) have been worldwide threats nowadays. Liver fibrosis is reversible in early stages but will develop precancerosis of HCC in cirrhotic stage. In pathological liver, excessive H2O2 is generated and accu
Externí odkaz:
https://doaj.org/article/0b08fd93af8e404fadbd9f8f4afa7eec
Autor:
Laure-Alix Clerbaux, Pierre Cordier, Nina Desboeufs, Kristian Unger, Peter Leary, Gabriel Semere, Yannick Boege, Lap Kwan Chan, Chantal Desdouets, Massimo Lopes, Achim Weber
Publikováno v:
JHEP Reports, Vol 5, Iss 10, Pp 100838- (2023)
Background & Aims: Mcl-1, an antiapoptotic protein overexpressed in many tumours, including hepatocellular carcinoma (HCC), represents a promising target for cancer treatment. Although Mcl-1 non-apoptotic roles might critically influence the therapeu
Externí odkaz:
https://doaj.org/article/5f8d2726cb3b4e978c92f8e81851c77a
Autor:
Siying Wang, Yangyang Zhou, Ruobing Yu, Jing Ling, Botai Li, Chen Yang, Zhuoan Cheng, Ruolan Qian, Zhang Lin, Chengtao Yu, Jiaojiao Zheng, Xingling Zheng, Qi Jia, Wei Wu, Qiangxin Wu, Mengnuo Chen, Shengxian Yuan, Wei Dong, Yaoping Shi, Robin Jansen, Yujun Hao, Ming Yao, Wenxin Qin, Haojie Jin
Publikováno v:
JHEP Reports, Vol 5, Iss 10, Pp 100843- (2023)
Background & Aims: Exploiting key regulators responsible for hepatocarcinogenesis is of great importance for the prevention and treatment of hepatocellular carcinoma (HCC). However, the key players contributing to hepatocarcinogenesis remain poorly u
Externí odkaz:
https://doaj.org/article/2b9a76a9f8dc434a842fc6f8be8e1f2b
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 6, Pp 1351-1369 (2023)
Background & Aims: Complex communications between hepatocytes and Kupffer cells (KCs) are known to drive or suppress hepatocarcinogenesis, with controversial data in the literature. In previous experiments that aimed to decipher hepatocyte/KC interac
Externí odkaz:
https://doaj.org/article/fbf22ff817e64ceaaa6b4a6e3a01135f