Zobrazeno 1 - 10
of 18 531
pro vyhledávání: '"hepatic stellate cell"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Radiation-induced liver fibrosis (RILF) is a common manifestation of radiation-induced liver injury (RILI) and is caused primarily by activated hepatic stellate cells (HSCs). Circular RNAs (circRNAs) play critical roles in various
Externí odkaz:
https://doaj.org/article/3fee06c2640f474389667617e0a8b125
Autor:
Ayana Fujiwara, Keisuke Takemura, Anna Tanaka, Misaki Matsumoto, Masato Katsuyama, Takeshi Okanoue, Kanji Yamaguchi, Yoshito Itoh, Kazumi Iwata, Kikuko Amagase, Atsushi Umemura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Because hepatic stellate cells (HSCs) play a major role in fibrosis, we focused on HSCs as a potential target for the treatment of liver fibrosis. In this study, we attempted to identify drug candidates to inactivate HSCs and found that seve
Externí odkaz:
https://doaj.org/article/b3a0293e746b4e4aa4f6b1fa1200d07d
Autor:
Dianyuan Zhao, Ziwei Huang, Xiaoyu Li, Huan Wang, Qingwei Hou, Yuyao Wang, Fang Yan, Wenting Yang, Di Liu, Shaoqiong Yi, Chunguang Han, Yanan Hao, Li Tang
Publikováno v:
eLife, Vol 13 (2024)
The liver is the largest solid organ in the body and is primarily composed of hepatocytes (HCs), endothelial cells (ECs), Kupffer cells (KCs), and hepatic stellate cells (HSCs), which spatially interact and cooperate with each other to maintain liver
Externí odkaz:
https://doaj.org/article/dcb3c08039e841efa62e95fb9db7f150
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 10, Pp n/a-n/a (2024)
ABSTRACT Background and aims Myofibroblasts, the primary producers of extracellular matrix, primarily originate from hepatic stellate cells (HSCs), and their activation plays a pivotal role in liver fibrosis. This study aimed to investigate the funct
Externí odkaz:
https://doaj.org/article/bdbc2e34c9fe4313bc00d6707a867085
Autor:
Xuecui Yin, Lin Dong, Xiaohan Wang, Zhenzhen Qin, Yuying Ma, Xiaofei Ke, Ya Li, Qingde Wang, Yang Mi, Quanjun Lyu, Xia Xu, Pengyuan Zheng, Youcai Tang
Publikováno v:
Animal Models and Experimental Medicine, Vol 7, Iss 2, Pp 166-178 (2024)
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases globally. Hepatic stellate cells (HSCs) are the major effector cells of liver fibrosis. HSCs contain abundant lipid droplets (LDs) in their
Externí odkaz:
https://doaj.org/article/819eb71873144d5eade6111c079560ce
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Liver fibrosis, as a consequence of chronic liver disease, involves the activation of hepatic stellate cell (HSC) caused by various chronic liver injuries. Emerging evidence suggests that activation of HSC during an inflammatory state can le
Externí odkaz:
https://doaj.org/article/b21704a104814240a7150abfa75f7c3e
Publikováno v:
Waike lilun yu shijian, Vol 29, Iss 02, Pp 126-131 (2024)
The liver is the most common site of metastasis in patients with colorectal cancer(CRC). The liver microenvironment is a diverse assemblage of cells, which has their own unique biological characteristics and functions, supplemented by the interaction
Externí odkaz:
https://doaj.org/article/a222f7371f7d411191d467babd27b87b
Publikováno v:
Journal of the National Cancer Center, Vol 4, Iss 1, Pp 25-35 (2024)
Hepatic stellate cells (HSCs), a distinct category of non-parenchymal cells in the liver, are critical for liver homeostasis. In healthy livers, HSCs remain non-proliferative and quiescent. However, under conditions of acute or chronic liver damage,
Externí odkaz:
https://doaj.org/article/e8a48dd8b27d4d9c8e20070b7a8df46f
Autor:
Lijun Chen, Yuqi Huang, Ning Zhang, Jingjing Qu, Yangxin Fang, Jiamin Fu, Yin Yuan, Qi Zhang, Hang Li, Zuoshi Wen, Li Yuan, Lu Chen, Zhenyu Xu, Yifei Li, Huadong Yan, Hiromi Izawa, Lanjuan Li, Charlie Xiang
Publikováno v:
MedComm, Vol 5, Iss 8, Pp n/a-n/a (2024)
Abstract Liver fibrosis can cause hepatitis B virus (HBV)‐associated hepatocellular carcinoma. Menstrual blood‐derived mesenchymal stem cells (MenSCs) can ameliorate liver fibrosis through paracrine. Single‐cell RNA sequencing (scRNA‐seq) may
Externí odkaz:
https://doaj.org/article/4947c98010b847b6abeebdc76fa25740
Autor:
Yiheng Zhang, Mulan Xing, Fansheng Meng, Ling Zhu, Qingchuan Huang, Tianle Ma, Huihua Fang, Xujing Gu, Suzhou Huang, Xinyu Wu, Gaohong Lv, Jun Guo, Li Wu, Xin Liu, Zhipeng Chen
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151427- (2024)
In the development of chronic liver disease, the hepatic stellate cell (HSC) plays a pivotal role in increasing intrahepatic vascular resistance (IHVR) and inducing portal hypertension (PH) in cirrhosis. Our research demonstrated that HSC contraction
Externí odkaz:
https://doaj.org/article/911ea4c9419e4a93b36541503a9d3928