Zobrazeno 1 - 10
of 868
pro vyhledávání: '"hepatic differentiation"'
Publikováno v:
Bioactive Materials, Vol 41, Iss , Pp 611-626 (2024)
The specific induction of hepatic differentiation presents a significant challenge in developing alternative liver cell sources and viable strategies for clinical therapy of acute liver failure (ALF). The past decade has witnessed the blossom of micr
Externí odkaz:
https://doaj.org/article/1bee14913dbf4b5ea0e41ff8de8bda5f
Autor:
Jiwan Choi, Seoon Kang, Hye-In An, Chae-Eun Kim, Sanghwa Lee, Chan-Gi Pack, Young-In Yoon, Hana Jin, Yong-Pil Cho, Chong Jai Kim, Jung-Man Namgoong, Jun Ki Kim, Eunyoung Tak
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Human mesenchymal stem cells originating from umbilical cord matrix are a promising therapeutic resource, and their differentiated cells are spotlighted as a tissue regeneration treatment. However, there are limitations to the med
Externí odkaz:
https://doaj.org/article/b6748173238948e0a688fa5db16d04e2
Autor:
Xiangfei Yuan, Yang Lu, Yuanyuan Yang, Wencong Tian, Dongmei Fan, Ruoqi Liu, Xiaomin Lei, Yafei Xia, Lei Yang, Shu Yan, Dongsheng Xiong
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTWe previously established a hepatocellular carcinoma (HCC) targeting system of conditionally replicative adenovirus (CRAd) delivered by human umbilical cord-derived mesenchymal stem cells (HUMSCs). However, this system needed to be developed
Externí odkaz:
https://doaj.org/article/31777795ee204dbdbe02a8e09bcdf3e0
Akademický článek
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Akademický článek
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Autor:
Tingcai Pan, Ning Wang, Jiaye Zhang, Fan Yang, Yan Chen, Yuanqi Zhuang, Yingying Xu, Ji Fang, Kai You, Xianhua Lin, Yang Li, Shao Li, Kangyan Liang, Yin-xiong Li, Yi Gao
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-14 (2022)
Abstract Background Various methods have been developed to generate hepatic cells from human pluripotent stem cells (hPSCs) that rely on the combined use of multiple expensive growth factors, limiting industrial-scale production and widespread applic
Externí odkaz:
https://doaj.org/article/45c1121c38f644a38b0f386eaf94a1a7
Akademický článek
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Autor:
Pouria Fattahi, Jose M. de Hoyos-Vega, Jong Hoon Choi, Caden D. Duffy, Alan M. Gonzalez-Suarez, Yuji Ishida, Kianna M. Nguyen, Kihak Gwon, Quinn P. Peterson, Takeshi Saito, Gulnaz Stybayeva, Alexander Revzin
Publikováno v:
Cells, Vol 12, Iss 15, p 1982 (2023)
Human pluripotent stem cells (hPSCs) are capable of unlimited proliferation and can undergo differentiation to give rise to cells and tissues of the three primary germ layers. While directing lineage selection of hPSCs has been an active area of rese
Externí odkaz:
https://doaj.org/article/a37baaa26ed144c583c718d6c96e880b
Autor:
Giuseppe Ietto, Valentina Iori, Mattia Gritti, Davide Inversini, Angelita Costantino, Sofia Izunza Barba, Z. Gordon Jiang, Giulio Carcano, Daniela Dalla Gasperina, Giuseppe Pettinato
Publikováno v:
Cells, Vol 12, Iss 10, p 1429 (2023)
Over 40,000 patients in the United States are estimated to suffer from end-stage liver disease and acute hepatic failure, for which liver transplantation is the only available therapy. Human primary hepatocytes (HPH) have not been employed as a thera
Externí odkaz:
https://doaj.org/article/92c09068975f446ca76cc83c6eb4d85c
Autor:
Akihiro Morita, Yuta Omoya, Rie Ito, Yuya Ishibashi, Keiichi Hiramoto, Shiho Ohnishi, Nobuji Yoshikawa, Shosuke Kawanishi
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101181- (2021)
The acute liver disease is involved in aberrant release of high-mobility group box 1 (HMGB1). Glycyrrhizin (GL), a traditional Chinese medicine for liver disease, binds to HMGB1, thereby inhibits tissue injury. However the mode of action of GL for ch
Externí odkaz:
https://doaj.org/article/925061da8e2a4c22b705612e946e2871