Zobrazeno 1 - 10
of 45
pro vyhledávání: '"hemoglobin switch"'
Autor:
Pamela Himadewi, Xue Qing David Wang, Fan Feng, Haley Gore, Yushuai Liu, Lei Yu, Ryo Kurita, Yukio Nakamura, Gerd P Pfeifer, Jie Liu, Xiaotian Zhang
Publikováno v:
eLife, Vol 10 (2021)
Mutations in the adult β-globin gene can lead to a variety of hemoglobinopathies, including sickle cell disease and β-thalassemia. An increase in fetal hemoglobin expression throughout adulthood, a condition named hereditary persistence of fetal he
Externí odkaz:
https://doaj.org/article/f57b54ffcd06452fa3926ecc23940b5f
Autor:
Olivier Negre, Swaroopa Guda, Christian Brendel, Chad E. Harris, Martin Bentler, Myriam Armant, Melissa Bonner, Erica B. Esrick, John P. Manis, Helene Trebeden-Negre, Axel Schambach, Alla V. Tsytsykova, Danilo Pellin, Michael Rothe, Lauryn Christiansen, Denise Klatt, David A. Williams, Meaghan McGuinness, Daniela Abriss, Geoff Parsons, Gabor Istvan Veres
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 589-600 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
In this work we provide preclinical data to support initiation of a first-in-human trial for sickle cell disease (SCD) using an approach that relies on reversal of the developmental fetal-to-adult hemoglobin switch. Erythroid-specific knockdown of BC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8fc0356964dd1fbe99f38977e8a66a
http://www.sciencedirect.com/science/article/pii/S2329050120300450
http://www.sciencedirect.com/science/article/pii/S2329050120300450
Autor:
Lei Yu, Jie Liu, Xiaotian Zhang, Yushuai Liu, Fan Feng, Gerd P. Pfeifer, Haley Gore, Ryo Kurita, Xue Qing David Wang, Yukio Nakamura, Pamela Himadewi
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Mutations in the adult β-globin gene can lead to a variety of hemoglobinopathies, including sickle cell disease and β-thalassemia. An increase in fetal hemoglobin expression throughout adulthood, a condition named hereditary persistence of fetal he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb04369936b1cbec1bb033aecc9f546
https://doi.org/10.7554/elife.70557
https://doi.org/10.7554/elife.70557
Akademický článek
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Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1984 Mar 01. 81(5), 1453-1456.
Externí odkaz:
https://www.jstor.org/stable/23495
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1981 Apr 01. 78(4), 2412-2416.
Externí odkaz:
https://www.jstor.org/stable/10186
Autor:
Frank J. T. Staal, Cornelis L. Harteveld, Hidde A. Zittersteijn, Rob C. Hoeben, Arjan C. Lankester, Manuel A F V Gonçalves, Stefanie Klaver-Flores
Publikováno v:
Frontiers in Genome Editing
Frontiers in Genome Editing, Vol 2 (2021)
Frontiers in Genome Editing, Vol 2 (2021)
Throughout the past decades, the search for a treatment for severe hemoglobinopathies has gained increased interest within the scientific community. The discovery that ɤ-globin expression from intact HBG alleles complements defective HBB alleles und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae89e3fb708b9c24817a252d8441b97
Autor:
Vasiliki Chondrou, Athanasios-Nasir Shaukat, Georgios Psarias, Katerina Athanasopoulou, Evanthia Iliopoulou, Ariadne Damanaki, Constantinos Stathopoulos, Argyro Sgourou
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7025
The hemoglobin switch from fetal (HbF) to adult (HbA) has been studied intensively as an essential model for gene expression regulation, but also as a beneficial therapeutic approach for β-hemoglobinopathies, towards the objective of reactivating Hb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463b0333a0482a6caa994d9e1385ef5f
https://doi.org/10.3390/ijms23137025
https://doi.org/10.3390/ijms23137025
Kniha
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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