Zobrazeno 1 - 10
of 2 172
pro vyhledávání: '"hemichannels"'
Publikováno v:
Tumour Virus Research, Vol 18, Iss , Pp 200296- (2024)
Connexins are essential for intercellular communication through gap junctions and the maintenance of cellular and tissue homeostasis. Connexin 43 (Cx43) is the most ubiquitously expressed connexin. As well as regulating homeostasis, Cx43 hemichannels
Externí odkaz:
https://doaj.org/article/f1c37dc1e91442fb9097415266069fd6
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-19 (2024)
Abstract Background Astrocytes Ca2+ signaling play a central role in the modulation of neuronal function. Activation of metabotropic glutamate receptors (mGluR) by glutamate released during an increase in synaptic activity triggers coordinated Ca2+ s
Externí odkaz:
https://doaj.org/article/dda85cb667d04576bf45c1236397b440
Autor:
Gonzalo I. Gómez, Tanhia F. Alvear, Daniela A. Roa, Arantza Farias-Pasten, Sergio A. Vergara, Luis A. Mellado, Claudio J. Martinez-Araya, Juan Prieto-Villalobos, Claudia García-Rodríguez, Natalia Sánchez, Juan C. Sáez, Fernando C. Ortíz, Juan A. Orellana
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-19 (2024)
Abstract Background Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that non-voluntary alcoho
Externí odkaz:
https://doaj.org/article/f80f0199ed6744449b3c85991d733a5d
Autor:
Juan C. Sáez, Justin C. Burrell, Catherine M. Cahill, D. Kacy Cullen, Lakshmi A. Devi, Ryan J. Gilbert, Zachary A. Graham, Vadim J. Gurvich, Leif A. Havton, Ravi Iyengar, Rajesh Khanna, Edmund F. Palermo, Mustafa Siddiq, Carlos A. Toro, Walter Vasquez, Wei Zhao, Christopher P. Cardozo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Over the past decade, boldine, a naturally occurring alkaloid found in several plant species including the Chilean Boldo tree, has garnered attention for its efficacy in rodent models of human disease. Some of the properties that have been attributed
Externí odkaz:
https://doaj.org/article/07edf235e1324a7b9a58860ef7edcbde
Autor:
Tanhia F. Alvear, Arantza Farias-Pasten, Sergio A. Vergara, Juan Prieto-Villalobos, Antonia Silva-Contreras, Fernando A. Fuenzalida, Rodrigo A. Quintanilla, Juan A. Orellana
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Alcohol, a toxic and psychoactive substance with addictive properties, severely impacts life quality, leading to significant health, societal, and economic consequences. Its rapid passage across the blood-brain barrier directly affects different brai
Externí odkaz:
https://doaj.org/article/3fedca9c8f814bfba07c75ceaeacd11e
Autor:
Manuel A. Riquelme, Xuewei Wang, Francisca M. Acosta, Jingruo Zhang, Jeffery Chavez, Sumin Gu, Peng Zhao, Wei Xiong, Ningyan Zhang, Guo Li, Saranya Srinivasan, Chaoyu Ma, Manjeet K. Rao, Lu-Zhe Sun, Nu Zhang, Zhiqiang An, Jean X. Jiang
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114377- (2024)
Summary: Bone tissue represents the most frequent site of cancer metastasis. We developed a hemichannel-activating antibody, Cx43-M2. Cx43-M2, directly targeting osteocytes in situ, activates osteocytic hemichannels and elevates extracellular ATP, th
Externí odkaz:
https://doaj.org/article/4756bc7168ea467aa3d390ca0185e247
Autor:
Gonzalo I. Gómez, Claudia García-Rodríguez, Jesús E. Marillán, Sergio A. Vergara, Tanhia F. Alvear, Arantza Farias-Pasten, Juan C. Sáez, Mauricio A. Retamal, Maximiliano Rovegno, Fernando C. Ortiz, Juan A. Orellana
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Multiple studies have demonstrated that acute ethanol consumption alters brain function and cognition. Nevertheless, the mechanisms underlying this phenomenon remain poorly understood. Astrocyte-mediated gliotransmission is crucial for hippocampal pl
Externí odkaz:
https://doaj.org/article/463f97fa14b444faa3d5873fc85c37d1
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Externí odkaz:
https://doaj.org/article/9dd9a2af8c8345fa8de7eb18eb3923ad
Autor:
Chidinma Adanna Okolo, Jack Jonathan Maran, Amy Watts, Jaime Maripillan, Maria Harkiolaki, Agustín D. Martínez, Colin R. Green, Odunayo Omolola Mugisho
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e27888- (2024)
Non-junctional connexin43 (Cx43) plasma membrane hemichannels have been implicated in several inflammatory diseases, particularly playing a role in ATP release that triggers activation of the inflammasome. Therapies targeting the blocking of the hemi
Externí odkaz:
https://doaj.org/article/e17a063b57c24edb96e75c070ffc7e0f