Zobrazeno 1 - 10
of 469
pro vyhledávání: '"heavy-chain antibody"'
Autor:
Ling Wang, Ran Luo, Weilang Zhang, Hanyu Jiang, Yongkang Yu, Wenhu Zhou, Fan Zhang, Jian Ma, Lin Mei
Publikováno v:
Smart Materials in Medicine, Vol 5, Iss 4, Pp 501-513 (2024)
Nanobody (Nb) is derived from the variable domain of heavy-chain antibody (HCAb), naturally displaying notable properties like nano-scale size, exceptional stability, high specificity, low immunogenicity, and cryptic epitope accessibility. These feat
Externí odkaz:
https://doaj.org/article/46f53d81aad441afa8025d01061b7619
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1705-1714 (2024)
Camelids produce both conventional tetrameric antibodies (Abs) and dimeric heavy-chain antibodies (HCAbs). Although B cells that generate these two types of Abs exhibit distinct B cell receptors (BCRs), whether these two B cell populations differ in
Externí odkaz:
https://doaj.org/article/d5b2fdea9fcf4229bdc7c5dd0352f9d8
Autor:
Xinyang Li, Wei Zhang, Yu Shu, Rui Huo, Chengyang Zheng, Qi Qi, Pengfei Fu, Jie Sun, Yuhuan Wang, Yan Wang, Juxu Lu, Xiangjie Zhao, Guoyou Yin, Qingqing Wang, Jun Hong
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target to reduce lipids. In 2020, we reported a chimeric camelid-human heavy chain antibody VHH-B11-Fc targeting PCSK9. Recently, it was verified th
Externí odkaz:
https://doaj.org/article/422e186089224805a86a2b4b39f77448
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
In this work, we report the discovery of potent anti-epidermal growth factor receptor (EGFR) allosteric heavy-chain antibodies by combining camelid immunization and fluorescence-activated cell sorting (FACS). After immunization and yeast surface disp
Externí odkaz:
https://doaj.org/article/47ecdc7002cb4c918adba46e3118162a
Autor:
Kexuan Cheng, Jiansheng Lu, Jiazheng Guo, Rong Wang, Lei Chen, Xi Wang, Yujia Jiang, Yating Li, Changyan Xu, Qinglin Kang, Gulisaina Qiaerxie, Peng Du, Chen Gao, Yunzhou Yu, Zhixin Yang, Wei Wang
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
Tetanus toxin (TeNT) is one of the most toxic proteins. Neutralizing antibodies against TeNT are effective in prevention and treatment. In this study, 14 anti-tetanus nanobodies were obtained from a phage display nanobody library by immunizing a came
Externí odkaz:
https://doaj.org/article/13b0ffc440814458b9e5816a3a74d3a7
Autor:
Gulisaina Qiaerxie, Yujia Jiang, Gege Li, Zhixin Yang, Feng Long, Yunzhou Yu, Jian Sheng Lu, Peng Du, Yong Cui
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
Among all natural and synthetic toxins, botulinum neurotoxins (BoNTs), produced by Clostridium botulinum in an anaerobic environment, are the most toxic polymer proteins. Currently, the most effective modalities for botulism prevention and treatment
Externí odkaz:
https://doaj.org/article/3b3fe064d75d437cbf9daed028543ef6
Autor:
Yujia Jiang, Rong Wang, Jiazheng Guo, Kexuan Cheng, Lei Chen, Xi Wang, Yating Li, Peng Du, Chen Gao, Jiansheng Lu, Yunzhou Yu, Zhixin Yang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundBotulinum neurotoxin (BoNT) produced by Clostridium botulinum is one of the most potent known toxins. Moreover, BoNT is classified as one of the most important biological warfare agents that threatens the biosafety of the world. Currently,
Externí odkaz:
https://doaj.org/article/378a8cb9a0244879bdbfffd6cf77c7ed
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