Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42-mediated cytotoxicity

Autor: Ellanor L. Whiteley, Ryan T. Cameron, Anna I. Parachikova, George S. Baillie, Jon P. Day

Publikováno v: FEBS Open Bio

Phosphodiesterase (PDE) inhibitors are currently under evaluation as agents that may facilitate the improvement of cognitive impairment associated with Alzheimer's disease. Our aim was to determine whether inhibitors of PDEs 4, 5 and 9 could alleviat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c704d7ca8af04bd7fc8c37782a055c22
https://doi.org/10.1002/2211-5463.12156

Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42-mediated cytotoxicity.

Autor: Cameron RT; Institute of Cardiovascular and Medical Sciences College of Veterinary Medical and Life Sciences University of Glasgow UK., Whiteley E; Institute of Cardiovascular and Medical Sciences College of Veterinary Medical and Life Sciences University of Glasgow UK., Day JP; Institute of Cardiovascular and Medical Sciences College of Veterinary Medical and Life Sciences University of Glasgow UK., Parachikova AI; Synaptic Transmission H. Lundbeck A/S Valby Denmark., Baillie GS; Institute of Cardiovascular and Medical Sciences College of Veterinary Medical and Life Sciences University of Glasgow UK.

Publikováno v: FEBS open bio [FEBS Open Bio] 2016 Dec 05; Vol. 7 (1), pp. 64-73. Date of Electronic Publication: 2016 Dec 05 (Print Publication: 2017).