Zobrazeno 1 - 10
of 3 115
pro vyhledávání: '"heat shock protein 90"'
Autor:
David I. Duron, Parthasaradhireddy Tanguturi, Christopher S. Campbell, Kerry Chou, Paul Bejarano, Katherin A. Gabriel, Jessica L. Bowden, Sanket Mishra, Christopher Brackett, Deborah Barlow, Karen L. Houseknecht, Brian S. J. Blagg, John M. Streicher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Opioids are the gold standard for the treatment of chronic pain but are limited by adverse side effects. In our earlier work, we showed that Heat shock protein 90 (Hsp90) has a crucial role in regulating opioid signaling in spinal cord; Hsp9
Externí odkaz:
https://doaj.org/article/224dd647f0154ca4bb4c8f2811b73164
Publikováno v:
BioChem, Vol 4, Iss 2, Pp 62-89 (2024)
Heat Shock Protein 90 (Hsp90) acts as a crucial molecular chaperone, playing an essential role in activating numerous signaling proteins. The intricate mechanism of Hsp90 involving ATPase-coupled conformational changes and interactions with cochapero
Externí odkaz:
https://doaj.org/article/384216e9d1224df39d4dcef17847d5d1
Autor:
Lejiao Jia, Huatian Yang, Yue Liu, Ying Zhou, Guosheng Li, Qian Zhou, Yan Xu, Zhiping Huang, Feng Ye, Jingjing Ye, Anchang Liu, Chunyan Ji
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Heat shock protein 90 (HSP90) is overexpressed in numerous cancers, promotes the maturation of numerous oncoproteins and facilitates cancer cell growth. Certain HSP90 inhibitors have entered clinical trials. Although less than satisfactory c
Externí odkaz:
https://doaj.org/article/ed0cedabd2964422b66ccc1bcd4f7bc5
Publikováno v:
European Journal of Entomology, Vol 121, Iss 1, Pp 54-63 (2024)
Spodoptera frugiperda, a worldwide pest, can feed on 353 crops species, including corn, rice, and sorghum. It is highly adaptable to various environments. Heat shock protein 90 kDa (Hsp90) plays a crucial role in the environmental adaptation of insec
Externí odkaz:
https://doaj.org/article/8e2727c30bce49dc95929b89318cb04a
Autor:
Shawn J. Hoogstra, Kyle N. Hendricks, David R. McMullin, Justin B. Renaud, Juhi Bora, Mark W. Sumarah, Christopher P. Garnham
Publikováno v:
Toxins, Vol 16, Iss 9, p 404 (2024)
Zearalenone and radicicol are resorcylic acid lactones produced by numerous plant pathogenic fungi. Zearalenone is a non-steroidal estrogen mimic that can cause serious reproductive issues in livestock that consume contaminated feed. Radicicol is a p
Externí odkaz:
https://doaj.org/article/c66f2c7b35ac429a88df281dbdce4d7a
Autor:
Amanda G. Smith, Valentin M. Kliebe, Sanket Mishra, Ryan P. McCall, Megan M. Irvine, Brian S. J. Blagg, Wei Lei
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Heat shock protein 90 (Hsp90) is a family of chaperone proteins that consists of four isoforms: Hsp90α, Hsp90β, glucose-regulated protein 94 (Grp94), and tumor necrosis factor type 1 receptor-associated protein (TRAP1). They are involved in modulat
Externí odkaz:
https://doaj.org/article/086fa855d2da4cde8523b71a382fcb37
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Heat shock protein 90 (Hsp90) is a molecular chaperone important for maintaining protein homeostasis (proteostasis) in the cell. Hsp90 inhibitors are being explored as cancer therapeutics because of their ability to disrupt proteostasis. Inhibiting H
Externí odkaz:
https://doaj.org/article/0afd9a57c5af4e4e990b6abb435b12a6
Publikováno v:
Cancer Management and Research, Vol Volume 15, Pp 1165-1179 (2023)
Xiteng Yin,1,2 Hongbo Zhang,1,2 Zheng Wei,2,3 Yufeng Wang,1,2 Shengwei Han,1,2 Meng Zhou,4 Wenguang Xu,1,2 Wei Han1,2 1Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing Unive
Externí odkaz:
https://doaj.org/article/9ed2039e37d04ef585066313bb95d846
Autor:
Hiraku Ogata, Yosuke Minami
Publikováno v:
International Journal of Translational Medicine, Vol 3, Iss 3, Pp 389-398 (2023)
FLT3 mutations are frequently identified in acute myeloid leukemia (AML). In particular, FLT3-ITD is known to be an indicator of a poor prognosis. FLT3 inhibitors have improved the treatment outcomes of AML patients with mutated FLT3. However, severa
Externí odkaz:
https://doaj.org/article/a96f672e0e0d4a9fad960154eecec35b
Publikováno v:
SLAS Discovery, Vol 28, Iss 6, Pp 249-254 (2023)
The genesis of most older medicinal agents has generally been empirical. During the past one and a half centuries, at least in the Western countries, discovering and developing drugs has been primarily the domain of pharmaceutical companies largely b
Externí odkaz:
https://doaj.org/article/12f59415c4b7418f9a3b2fd3ab9e7f03