Zobrazeno 1 - 10
of 643
pro vyhledávání: '"healthy volunteer"'
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-9 (2024)
Abstract Background The emergence of resistance to artemisinin-based combination therapy necessitates the search for new, more potent antiplasmodial compounds, including herbal remedies. The whole extract of Maytenus senegalensis has been scientifica
Externí odkaz:
https://doaj.org/article/23218810f0ac45309e807f4d12b942a3
Autor:
Alejandro Carazo, Marcel Hrubša, Lukáš Konečný, Catherine Gunaseelan, Jaka Fadraersada, Pavel Skořepa, Markéta Paclíková, František Musil, Jana Karlíčková, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Alena Šmahelová, Vladimír Blaha, Přemysl Mladenka
Publikováno v:
Platelets, Vol 35, Iss 1 (2024)
AbstractPlatelet aggregation is a complicated process mediated by different signaling pathways. As the process is highly complex and apparently redundant, the relationships between these pathways are not yet fully known. The aim of this project was t
Externí odkaz:
https://doaj.org/article/240926563f954eb0a303bf7cf0825291
Autor:
Jon-Emile S. Kenny, Ross Prager, Philippe Rola, Garett McCulloch, Joseph K. Eibl, Korbin Haycock
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Background The venous excess ultrasound (VExUS) score is a multi-organ Doppler approach to assess venous congestion. Despite growing use of VExUS in research and clinical practice, other veins can be visualized to assess for venous hypertens
Externí odkaz:
https://doaj.org/article/5bc51a9296ee428ba7ddb7008dbb1b7e
Autor:
Jessica Goss, Pamela Hair, Parvathi Kumar, Giuseppina Iacono, Laura Redden, Gaetano Morelli, Neel Krishna, Ulrich Thienel, Kenji Cunnion
Publikováno v:
Translational Medicine Communications, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Background RLS-0071 is a novel 15 amino acid peptide dual-targeting anti-inflammatory inhibitor of complement and neutrophil effectors. RLS-0071 inhibits classical complement pathway activation at C1 and blocks the enzymatic activity of myel
Externí odkaz:
https://doaj.org/article/9a63669d6e5b47da9dd36fc9379030b7
Publikováno v:
EJNMMI Physics, Vol 9, Iss 1, Pp 1-11 (2022)
Abstract Background To confirm the performance of the first hemispherical positron emission tomography (PET) for the brain (Vrain) that we developed to visualise the small nuclei in the deep brain area, we compared 18F-fluorodeoxyglucose (FDG) brain
Externí odkaz:
https://doaj.org/article/158782eff22a4cad950b0d83e1752160
Autor:
Salma Assil, Thomas P. Buters, Pieter W. Hameeteman, Charlie Hallard, Nicoline Treijtel, Tessa Niemeyer – Van der Kolk, Marieke L. de Kam, Edwin F. I. I. I. Florencia, Errol P. Prens, Martijn B. A. van Doorn, Robert Rissmann, Naomi B. Klarenbeek, Manon A. A. Jansen, Matthijs Moerland
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Imiquimod (IMQ) is a topical agent that induces local inflammation via the Toll-like receptor 7 pathway. Recently, an IMQ-driven skin inflammation model was developed in healthy volunteers for proof-of-pharmacology trials. The aim of this study was t
Externí odkaz:
https://doaj.org/article/f03a8555dda44e0c8f9b4a37d47243ce
Autor:
Hengyi Yu, Xingxing Qi, Yinian Fang, Kaifu Wang, Donglin Zhang, Qian Chen, Dong Liu, Xiuhua Ren
Publikováno v:
Heliyon, Vol 9, Iss 7, Pp e17905- (2023)
Somnolence is a common adverse effect of antipsychotic drugs used to treat psychotic disorders. It causes problems in many areas of life, such as gainful employment, driving, childcare, and social interactions. Somnolence is a major problem for a rel
Externí odkaz:
https://doaj.org/article/544339f0ab2648f1b83f9ff00619e621
Autor:
Jon-Emile S. Kenny, Ross Prager, Philippe Rola, Garett McCulloch, Sarah Atwi, Chelsea E. Munding, Joseph K. Eibl, Korbin Haycock
Publikováno v:
Diagnostics, Vol 13, Iss 23, p 3591 (2023)
(1) Background: The inspiratory collapse of the inferior vena cava (IVC), a non-invasive surrogate for right atrial pressure, is often used to predict whether a patient will augment stroke volume (SV) in response to a preload challenge. There is a co
Externí odkaz:
https://doaj.org/article/27b6b20245014f5fb6bfcc897f50bac2
Autor:
Niels Okkels, Jacob Horsager, Miguel A. Labrador-Espinosa, Frederik O. Hansen, Katrine B. Andersen, Mie Kristine Just, Tatyana D. Fedorova, Casper Skjærbæk, Ole L. Munk, Kim V. Hansen, Hanne Gottrup, Allan K. Hansen, Michel J. Grothe, Per Borghammer
Publikováno v:
NeuroImage, Vol 269, Iss , Pp 119908- (2023)
Introduction: [18F]fluoroetoxybenzovesamicol ([18F]FEOBV) is a positron emission topography (PET) tracer for the vesicular acetylcholine transporter (VAChT), a protein located predominantly in synaptic vesicles in cholinergic nerve terminals. We aime
Externí odkaz:
https://doaj.org/article/caac9405089a4f35a1aa5b913d872eba
Publikováno v:
Frontiers in Human Neuroscience, Vol 16 (2023)
BackgroundPrevious studies indicated the sedative effect of acupoint stimulation. However, its mechanism remains unclear. This study aimed to investigate the sedative effect of transcutaneous electrical acupoint stimulation (TEAS) and to explore the
Externí odkaz:
https://doaj.org/article/892cf5ce8e85426eb331767a649576c6