Zobrazeno 1 - 10
of 14 387
pro vyhledávání: '"hdac"'
Autor:
Sadaf Kalsum, Mira Akber, Marco Giulio Loreti, Blanka Andersson, Eva Danielson, Maria Lerm, Susanna Brighenti
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Host-directed therapies aiming to strengthen the body’s immune system, represent an underexplored opportunity to improve treatment of tuberculosis (TB). We have previously shown in Mycobacterium tuberculosis (Mtb)-infection models and clin
Externí odkaz:
https://doaj.org/article/97b2c344b16042e3834c7798655b9761
Autor:
Mohammad-Salar Hosseini, Zohreh Sanaat, Mohammad Amin Akbarzadeh, Yosra Vaez-Gharamaleki, Mahsa Akbarzadeh
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-19 (2024)
Abstract Leukemia remains a major therapeutic challenge in clinical oncology. Despite significant advancements in treatment modalities, leukemia remains a significant cause of morbidity and mortality worldwide, as the current conventional therapies a
Externí odkaz:
https://doaj.org/article/c2093e559cf94965849f097ebaab2637
Autor:
Anthony M. Baudino, Harris F. Ciaccio, Michael J. Turski, Xavier A. Akins, Phoebus Sun Cao, Elisa Morales, Roger D. Sommer, Adam R. Johnson, Donald J. Wink, Kyle A. Grice, Kari L. Stone
Publikováno v:
Foundations, Vol 4, Iss 3, Pp 362-375 (2024)
Zinc is integral to diverse biological functions, acting catalytically, structurally, and supportively in essential enzyme cycles, despite its limited amounts in the body. Targeting zinc enzymes with potent drugs, such as Vorinostat, demonstrates the
Externí odkaz:
https://doaj.org/article/858b2f61f78e4bf4b6c49765069f8bc9
Autor:
Michela Gottardi Zamperla, Barbara Illi, Veronica Barbi, Chiara Cencioni, Daniele Santoni, Stella Gagliardi, Maria Garofalo, Gabriele Antonio Zingale, Irene Pandino, Diego Sbardella, Lina Cipolla, Simone Sabbioneda, Antonella Farsetti, Chiara Ripamonti, Gianluca Fossati, Christian Steinkühler, Carlo Gaetano, Sandra Atlante
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Histone deacetylases (HDACs) are crucial regulators of gene expression, DNA synthesis, and cellular processes, making them essential targets in cancer research. HDAC6, specifically, influences protein stability and chromatin dynam
Externí odkaz:
https://doaj.org/article/1aee7acab3d541f682bf1fe58ec3c016
Autor:
Alica Fischle, Mika Lutsch, Florian Hübner, Linda Schäker-Hübner, Lina Schürmann, Finn K. Hansen, Svetlana A. Kalinina
Publikováno v:
Natural Products and Bioprospecting, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Apicidins are a class of naturally occurring cyclic tetrapeptides produced by few strains within the Fusarium genus. These secondary metabolites have gained significant attention due to their antiprotozoal activity through HDAC inhibition, t
Externí odkaz:
https://doaj.org/article/6949c4f457304e46a17e0c33a1681c9c
Autor:
Shefali Chauhan, Emily Lian, Iman Habib, Qianqian Liu, Nicole M. Anders, Megan M. Bugg, Noah C. Federman, Joel M. Reid, Clinton F. Stewart, Tristan Cates, Joel E. Michalek, Charles Keller
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma. For the alveolar subtype (ARMS), the presence of the PAX3::FOXO1 fusion gene and/or metastases are strong predictors of poor outcome. Metastatic PAX3::FOXO1 + ARMS ofte
Externí odkaz:
https://doaj.org/article/f0d777b3277b40b58dcedcf300719a97
Autor:
Nair Lopes, Sofia Salta, Bianca Troncarelli Flores, Vera Miranda-Gonçalves, Margareta P. Correia, Davide Gigliano, Rita Guimarães, Rui Henrique, Carmen Jerónimo
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Oesophageal cancer remains a challenging disease with high mortality rates and few therapeutic options. In view of these difficulties, epigenetic drugs have emerged as potential alternatives for patient care. The goal of this stud
Externí odkaz:
https://doaj.org/article/a6e805f969c24f529614687cebfbde21
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract This study explores migrasomes' role in neuroblastoma, a common malignant tumor in children, and their potential impact on tumor formation. We analyzed neuroblastoma RNA-seq datasets from public databases, including GSE62564, GSE181559, targ
Externí odkaz:
https://doaj.org/article/2ba71b30effc48bf94365ca3795bc3d9
Autor:
Ran He, Luyang Xu, Maochuan Guo, Kai Cheng, Ziyi Song, Yue Xie, Hui Wang, Xuan Zhou, Xiaobin Gu, Jing Xu, Huidan Deng, Guangyou Yang
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 12 (2024)
ABSTRACT Scabies is a contagious zoonotic parasitic disease that causes a substantial risk to both human and animal health and results in significant financial losses. No vaccine is available for scabies, and drug resistance to the conventional treat
Externí odkaz:
https://doaj.org/article/bc8a801a48814834b4615aee8525aa51
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 4, Pp 151463- (2024)
Epigenetic editing is thriving as a robust tool for manipulating transcriptional regulation and cell fate. Despite its regulatory role in gene downregulation, epigenetic editing with histone deacetylation has been sparsely studied, especially in the
Externí odkaz:
https://doaj.org/article/7de650bc5a44463580007d328bcf96c0