Zobrazeno 1 - 10
of 19
pro vyhledávání: '"hPSC, human pluripotent stem cell"'
Autor:
Ryota Tabei, Yujiro Kawai, Kazuaki Nakajima, Satoshi Kunita, Shota Someya, Jun Fujita, Hidenori Tani, Keiichi Fukuda, Yoshikazu Kishino, Hideaki Kanazawa, Shugo Tohyama, Takumi Teratani, Akira Ito, Noriko Handa, Akinori Hirano, Rei Shibata, Sho Tanosaki, Eiji Kobayashi, Shuji Hishikawa, Marina Okada, Hideyuki Shimizu, Masataka Yamazaki, Shigeo Okuda, Yoshitake Yamada, Yusuke Soma, Yasuhiko Tabata, Yuika Morita, Shinji Kawaguchi, Toyoaki Murohara
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • hiPSCs are differentiated into CMs with large-scale 2-dimensional culture system, and refined by metabolic purification. • hiPSC-derived CMs are developed into CSs in special microwell plates. • Intramyocardial
Highlights • hiPSCs are differentiated into CMs with large-scale 2-dimensional culture system, and refined by metabolic purification. • hiPSC-derived CMs are developed into CSs in special microwell plates. • Intramyocardial
Publikováno v:
Advanced Drug Delivery Reviews
Current preclinical studies in drug development utilize high-throughput in vitro screens to identify lead drug candidates, followed by both in vitro and in vivo models to predict lead candidates' pharmacokinetic and pharmacodynamic properties. The go
Autor:
Pei Yong Shi, Oleksandr Dmytrenko, Michael J. Greenberg, Xuping Xie, Mehrdad Saririan, Sanja Sviben, Vinay Penna, Pan Ma, Kent A. Heck, Michael S. Diamond, Chieh Yu Lin, W. Tom Stump, Erin G. Brooks, James A. J. Fitzpatrick, Ajith Nair, Andrea L. Bredemeyer, Emma S. Winkler, Weng Tein Gi, Jing Liu, J. Travis Hinson, Adam L. Bailey, Constanze Schmidt, Xianwen Zhang, Florian Leuschner, Aniket S Rali, Lina Greenberg, Dan Hobohm, Leo Simpson, Kory J. Lavine
Publikováno v:
JACC: Basic to Translational Science
bioRxiv
bioRxiv
Visual Abstract
There is ongoing debate as to whether cardiac complications of coronavirus disease 2019 (COVID-19) result from myocardial viral infection or are secondary to systemic inflammation and/or thrombosis. We provide evidence that cardi
There is ongoing debate as to whether cardiac complications of coronavirus disease 2019 (COVID-19) result from myocardial viral infection or are secondary to systemic inflammation and/or thrombosis. We provide evidence that cardi
Autor:
Victoria Karakis, Adriana San Miguel, Jessica Mahinthakumar, Celeste Carberry, Balaji M. Rao, Adam Mischler, Julia E. Rager, Rebecca C. Fry
Publikováno v:
The Journal of Biological Chemistry
The trophectoderm layer of the blastocyst-stage embryo is the precursor for all trophoblast cells in the placenta. Human trophoblast stem (TS) cells have emerged as an attractive tool for studies on early trophoblast development. However, the use of
Autor:
Mohsen Khosravi-Maharlooei, Rachel Madley, Chiara Borsotti, Leonardo M.R. Ferreira, Robert C. Sharp, Michael A. Brehm, Dale L. Greiner, Audrey V. Parent, Mark S. Anderson, Megan Sykes, Remi J. Creusot
Publikováno v:
Molecular Metabolism
BackgroundType 1 diabetes (T1D) is an autoimmune disease characterized by impaired immune tolerance to β-cell antigens and progressive destruction of insulin-producing β-cells. Animal models have provided valuable insights for understanding the eti
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 353-363 (2018)
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 353-363 (2018)
Gastric diseases, including peptic ulcer disease and gastric cancer, are highly prevalent in human beings. Despite this, the cellular biology of the stomach remains poorly understood relative to other gastrointestinal organs such as the liver, intest
Autor:
Stephen J. Meltzer, Xi Liu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Gastric cancer (GC) remains the third most common cause of cancer death worldwide, with limited therapeutic strategies available. With the advent of next-generation sequencing and new preclinical model technologies, our understanding of its pathogene
Autor:
Jason R. Spence, David R. Hill
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 2, Pp 138-149 (2017)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
In recent years, increasing attention has been devoted to the concept that microorganisms play an integral role in human physiology and pathophysiology. Despite this, the molecular basis of hostâpathogen and hostâsymbiont interactions in the human
Autor:
Wei-Jun Qian, Chang Siang Lim, Manoj K. Gupta, Hwee Hui Lau, John L. Rinn, Marina A. Gritsenko, Larry Sai Weng Loo, William Mallard, Nicholas Jackson, Linh Nguyen, Richard D. Smith, Rohit N. Kulkarni, Adrian Kee Keong Teo
Publikováno v:
The Journal of Biological Chemistry
Human embryonic stem cells are a type of pluripotent stem cells (hPSCs) that are used to investigate their differentiation into diverse mature cell types for molecular studies. The mechanisms underlying insulin receptor (IR)-mediated signaling in the
Autor:
Miller, Duncan C., Harmer, Stephen C., Poliandri, Ariel, Nobles, Muriel, Edwards, Elizabeth C., Ware, James S., Sharp, Tyson V., McKay, Tristan R., Dunkel, Leo, Lambiase, Pier D., Tinker, Andrew
Publikováno v:
Stem Cell Research
Stem Cell Research, Vol 25, Iss C, Pp 233-244 (2017)
Miller, D C, Harmer, S C, Poliandri, A, Nobles, M, Edwards, E C, Ware, J S, Sharp, T V, McKay, T R, Dunkel, L, Lambiase, P D & Tinker, A 2017, ' Ajmaline blocks I Na and I Kr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters ', Stem Cell Research, vol. 25, pp. 233-244 . https://doi.org/10.1016/j.scr.2017.11.003
Stem Cell Research, Vol 25, Iss C, Pp 233-244 (2017)
Miller, D C, Harmer, S C, Poliandri, A, Nobles, M, Edwards, E C, Ware, J S, Sharp, T V, McKay, T R, Dunkel, L, Lambiase, P D & Tinker, A 2017, ' Ajmaline blocks I Na and I Kr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters ', Stem Cell Research, vol. 25, pp. 233-244 . https://doi.org/10.1016/j.scr.2017.11.003
The class Ia anti-arrhythmic drug ajmaline is used clinically to unmask latent type I ECG in Brugada syndrome (BrS) patients, although its mode of action is poorly characterised. Our aims were to identify ajmaline's mode of action in human induced pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e15170b085bbf3278ce0b9239bfd6c37
https://e-space.mmu.ac.uk/619960/
https://e-space.mmu.ac.uk/619960/