Zobrazeno 1 - 10
of 31
pro vyhledávání: '"hESC, human embryonic stem cell"'
Autor:
Sara Menegatti, Bethany Potts, Eva Garcia-Alegria, Roberto Paredes, Michael Lie-A-Ling, Georges Lacaud, Valerie Kouskoff
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The transcription factor RUNX1 is a master regulator of blood cell specification. During embryogenesis, hematopoietic progenitors are initially generated from hemogenic endothelium through an endothelium-to-hematopoietic transition controlled by RUNX
Externí odkaz:
https://doaj.org/article/a6f8d5f00ead4d83b87a2eb947b00fef
Autor:
Diana L. Cousminer, James A. Pippin, Kenyaita M. Hodge, Claudia A. Doege, Matthew E. Johnson, Reza K. Hammond, Michelle E. Leonard, Natalie A. Terry, Matthew C. Pahl, Rudolph L. Leibel, Struan F.A. Grant, Louis R. Ghanem, Chiara Lasconi, Alessandra Chesi, Andrew D. Wells, Sumei Lu, Chun Su
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 667-682 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 667-682 (2021)
Background & Aims Inflammatory bowel disease (IBD) is a polygenic disorder characterized principally by dysregulated inflammation impacting the gastrointestinal tract. However, there also is increasing evidence for a clinical association with stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3668c36ee2f5dc8c41707b138dee7d
https://doi.org/10.1016/j.jcmgh.2020.10.004
https://doi.org/10.1016/j.jcmgh.2020.10.004
Publikováno v:
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 4, Iss 3, Pp 315-338 (2020)
Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Mayo Clinic Proceedings: Innovations, Quality & Outcomes
An understanding of the molecular basis of liver regeneration will open new horizons for the development of novel therapies for chronic liver failure. Such therapies would solve the drawbacks associated with liver transplant, including the shortage o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57f94c2b2aed8589dc105db85be58c0
http://www.sciencedirect.com/science/article/pii/S2542454820300394
http://www.sciencedirect.com/science/article/pii/S2542454820300394
Publikováno v:
Advanced Drug Delivery Reviews
Current preclinical studies in drug development utilize high-throughput in vitro screens to identify lead drug candidates, followed by both in vitro and in vivo models to predict lead candidates' pharmacokinetic and pharmacodynamic properties. The go
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27450d16dc16ed032dd279f5267ef128
https://doi.org/10.1016/j.addr.2020.09.012
https://doi.org/10.1016/j.addr.2020.09.012
Autor:
Karl J. Wahlin, Jun Wan, Ravi Chakra Turaga, Cynthia A. Berlinicke, Jiang Qian, Joseph L. Mertz, Melissa M. Liu, Ming-Wen Hu, Donald J. Zack, Srinivasa R. Sripathi, Julien Maruotti
Publikováno v:
Molecular & Cellular Proteomics : MCP
Stress and injury to the retinal pigment epithelium (RPE) often lead to dedifferentiation and epithelial-to-mesenchymal transition (EMT). These processes have been implicated in several retinal diseases, including proliferative vitreoretinopathy, dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f434ce93c2c1575dac4028fd9af5368
http://europepmc.org/articles/PMC8482521
http://europepmc.org/articles/PMC8482521
Publikováno v:
Cell Regeneration, Vol 7, Iss 2, Pp 40-44 (2018)
Cell Regeneration
Cell Regeneration
As three decades ago, it was reported that adoptive T cell immunotherapy by infusion of autologous tumor infiltrating lymphocytes (TILs) mediated objective cancer regression in patients with metastatic melanoma. A new era of T cell immunotherapy aros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e93b7554b6ba66bb86ddaaf19ed553
https://doi.org/10.1016/j.cr.2018.09.002
https://doi.org/10.1016/j.cr.2018.09.002
Autor:
Victoria Karakis, Adriana San Miguel, Jessica Mahinthakumar, Celeste Carberry, Balaji M. Rao, Adam Mischler, Julia E. Rager, Rebecca C. Fry
Publikováno v:
The Journal of Biological Chemistry
The trophectoderm layer of the blastocyst-stage embryo is the precursor for all trophoblast cells in the placenta. Human trophoblast stem (TS) cells have emerged as an attractive tool for studies on early trophoblast development. However, the use of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e218649239c12b2ad7937121815a16bc
http://europepmc.org/articles/PMC7948510
http://europepmc.org/articles/PMC7948510
Publikováno v:
Journal of Molecular Biology
The novel SARS-CoV-2 virus outbreak is the major cause of a respiratory disease known as COVID-19. It has caused a global pandemic and has resulted in mortality in millions. The primary mode of infection is respiratory ailments, however, due to multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62501267315c032bde4f6084ae3c96d3
https://doi.org/10.1016/j.jmb.2021.167213
https://doi.org/10.1016/j.jmb.2021.167213
Autor:
Mehat, Manjit S, Sundaram, Venki, Ripamonti, Caterina, Robson, Anthony G, Smith, Alexander J, Borooah, Shyamanga, Robinson, Martha, Rosenthal, Adam N, Innes, William, Weleber, Richard G, Lee, Richard W J, Crossland, Michael, Rubin, Gary S, Dhillon, Baljean, Steel, David H W, Anglade, Eddy, Lanza, Robert P, Ali, Robin R, Michaelides, Michel, Bainbridge, James W B
Publikováno v:
Ophthalmology
Mehat, M S, Sundaram, V, Ripamonti, C, Robson, A G, Smith, A J, Borooah, S, Robinson, M, Rosenthal, A N, Innes, W, Weleber, R G, Lee, R W J, Crossland, M, Rubin, G S, Dhillon, B, Steel, D H W, Anglade, E, Lanza, R P, Ali, R R, Michaelides, M & Bainbridge, J W B 2018, ' Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in Macular Degeneration ', Ophthalmology: Journal of The American Academy of Ophthalmology . https://doi.org/10.1016/j.ophtha.2018.04.037
Mehat, M S, Sundaram, V, Ripamonti, C, Robson, A G, Smith, A J, Borooah, S, Robinson, M, Rosenthal, A N, Innes, W, Weleber, R G, Lee, R W J, Crossland, M, Rubin, G S, Dhillon, B, Steel, D H W, Anglade, E, Lanza, R P, Ali, R R, Michaelides, M & Bainbridge, J W B 2018, ' Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in Macular Degeneration ', Ophthalmology: Journal of The American Academy of Ophthalmology . https://doi.org/10.1016/j.ophtha.2018.04.037
PURPOSE: Transplantation of human embryonic stem cell (hESC)-derived retinal pigment epithelial (RPE) cells offers the potential for benefit in macular degeneration. Previous trials have reported improved visual acuity (VA), but lacked detailed analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::afba1d8ecfc283050a42387f7d7f2215
http://europepmc.org/articles/PMC6195794
http://europepmc.org/articles/PMC6195794
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