Zobrazeno 1 - 10
of 8 862
pro vyhledávání: '"hERG"'
Autor:
Jules C. Hancox, Yibo Wang, Caroline S. Copeland, Henggui Zhang, Stephen C. Harmer, Graeme Henderson
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 10, Iss , Pp 100118- (2024)
The growing use of nitazene synthetic opioids heralds a new phase of the opioid crisis. However, limited information exists on the toxic effects of these drugs, aside from a propensity for respiratory depression. With restricted research availability
Externí odkaz:
https://doaj.org/article/2ff2b0f1255a4afbadfc862be8ed9284
Autor:
Jufeng Wan, Haiying Xu, Jiaming Ju, Yingjie Chen, Hongxia Zhang, Lingling Qi, Yan Zhang, Zhimin Du, Xin Zhao
Publikováno v:
Translational Oncology, Vol 50, Iss , Pp 102137- (2024)
Colorectal cancer (CRC) is one of the most common malignant cancers. Emodin is a lipophilic anthraquinone commonly found in medicinal herbs and known for its antitumor properties. However, its clinical utility has been hampered by low druggability. W
Externí odkaz:
https://doaj.org/article/94da9ab91e5c4c8b9e7e0090284cccfe
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Cardiovascular diseases are a major global health concern, responsible for a significant number of deaths each year, often linked to cardiac arrhythmias resulting from dysfunction in ion channels. Hereditary Long QT Syndrome (LQTS) is a condition cha
Externí odkaz:
https://doaj.org/article/8c8e28bede7f487d954db54927791198
Autor:
Zhipei Liu, Feng Wang, Hui Yuan, Fuyun Tian, Chuanyan Yang, Fei Hu, Yiyao Liu, Meiqin Tang, Meixuan Ping, Chunlan Kang, Ting Luo, Guimei Yang, Mei Hu, Zhaobing Gao, Ping Li
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Cyclic Nucleotide-Binding Domain (CNBD)-family channels display distinct voltage-sensing properties despite sharing sequence and structural similarity. For example, the human Ether-a-go-go Related Gene (hERG) channel and the Hyper
Externí odkaz:
https://doaj.org/article/8236028ffddf49fa98aa85966b033d21
Publikováno v:
Diagnostics, Vol 14, Iss 17, p 1995 (2024)
Sudden, unexpected deaths are extremely difficult for families, especially when the victim is a child. Most sudden deaths occur due to cardiovascular issues, and a smaller number (approximately one-quarter) are attributed to other causes, such as epi
Externí odkaz:
https://doaj.org/article/1af83b51af894b61a253084b6ff6a087
Autor:
Meye Bloothooft, Bente Verbruggen, Fitzwilliam Seibertz, Marcel A. G. van der Heyden, Niels Voigt, Teun P. de Boer
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Background: The rapid delayed rectifier potassium current (IKr) is important for cardiac repolarization and is most often involved in drug-induced arrhythmias. However, accurately measuring this current can be challenging in human-induced pluripotent
Externí odkaz:
https://doaj.org/article/ae8be112595044e9923a346cd08dfa5f
Autor:
G. V. Mokrov
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 3-19 (2023)
The hERG subtype potassium channel (Kv11.1) is one of the most important and one of the most studied biological targets for the creation of cardioprotective agents. A large number of both blockers and activators/modulators of the hERG channel have be
Externí odkaz:
https://doaj.org/article/43a1aac1c6584e51b74bcc85df18821e
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 6, Iss , Pp 100049- (2023)
Synthetic cannabinoid receptor agonists (SCRAs) have been associated with QT interval prolongation. Limited preclinical information on SCRA effects on cardiac electrogenesis results from the rapid emergence of new compounds and restricted research av
Externí odkaz:
https://doaj.org/article/469ad58dd5ed4d1a87cb8c3c4a27c131
Autor:
Zhao Xin, Sun Lihua, Chen Chao, Xin Jieru, Zhang Yan, Bai Yunlong, Pan Zhenwei, Zhang Yong, Li Baoxin, Lv Yanjie, Yang Baofeng
Publikováno v:
Frigid Zone Medicine, Vol 3, Iss 2, Pp 105-113 (2023)
In March 2022, more than 600 million cases of Corona Virus Disease 2019 (COVID-19) and about 6 million deaths have been reported worldwide. Unfortunately, while effective antiviral therapy has not yet been available, chloroquine (CQ)/hydroxychloroqui
Externí odkaz:
https://doaj.org/article/ffc5bf5b174848b4a6e226c6344a1136
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