Dipeptidyl peptidase-4 marks distinct subtypes of human adipose stromal/stem cells with different hepatocyte differentiation and immunoregulatory properties.

Autor: Zhang, Yu¹ (AUTHOR), Hua, Mingxi^2,3 (AUTHOR), Ma, Xuqing¹ (AUTHOR), Li, Weihong⁴ (AUTHOR), Cao, Yuqi¹ (AUTHOR), Han, Xueya¹ (AUTHOR), Huang, Xiaowu⁵ (AUTHOR), Zhang, Haiyan^1,6 (AUTHOR) culture@ccmu.edu.cn

Publikováno v: Stem Cell Research & Therapy. 9/29/2024, Vol. 15 Issue 1, p1-20. 20p.

hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration

Autor: Dong Chen, Xin Jiang, Haibo Zou

Publikováno v: Journal of Orthopaedic Translation, Vol 39, Iss , Pp 163-176 (2023)

Background: Intervertebral disc degeneration (IDD) is a complex chronic disease involving nucleus pulposus cells (NPCs) senescence, apoptosis, autophagy and extracellular matrix (ECM) degradation. In this study, we aimed to investigate the role of hu

Externí odkaz: https://doaj.org/article/ddc6bfb979ff4e5e94584f727f04fdfd

Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration

Autor: Tian Tu, Yuan Shi, Boya Zhou, Xiaoyu Wang, Wenjie Zhang, Guangdong Zhou, Xiumei Mo, Wenbo Wang, Jinglei Wu, Wei Liu

Publikováno v: npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-18 (2023)

Abstract Our previous work demonstrated the tendon-derived extracellular matrix (ECM) extracts as vital niches to specifically direct mesenchymal stem cells towards tenogenic differentiation. This study aims to further define the effective ECM molecu

Externí odkaz: https://doaj.org/article/feb36b7bd11d48a18635b65a7986f92c

Epithelial differentiation of human adipose-derived stem cells (hASCs) undergoing three-dimensional (3D) cultivation with collagen sponge scaffold (CSS) via an indirect co-culture strategy.

Autor: Li, Minxiong¹ (AUTHOR), Ma, Jun¹ (AUTHOR), Gao, Yanbin¹ (AUTHOR), Dong, Mengru¹ (AUTHOR), Zheng, Zijun¹ (AUTHOR), Li, Yuchen¹ (AUTHOR), Tan, Rongwei² (AUTHOR), She, Zhending² (AUTHOR), Yang, Lei¹ (AUTHOR) yuanyang@fimmu.com

Publikováno v: Stem Cell Research & Therapy. 3/31/2020, Vol. 11 Issue 1, p1-16. 16p.

Actin polymerization regulates the osteogenesis of hASCs by influencing α-tubulin expression and Eg5 activity.

Autor: Fan T; Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics & Guangdong Engineering Research Center for Translation of Medical 3D Printing Application & National Virtual & Reality Experimental Education Center for Medical Morphology (Southern Medical University) & National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China., Liu W; Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics & Guangdong Engineering Research Center for Translation of Medical 3D Printing Application & National Virtual & Reality Experimental Education Center for Medical Morphology (Southern Medical University) & National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China., Qu R; Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics & Guangdong Engineering Research Center for Translation of Medical 3D Printing Application & National Virtual & Reality Experimental Education Center for Medical Morphology (Southern Medical University) & National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China., Zhu J; Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics & Guangdong Engineering Research Center for Translation of Medical 3D Printing Application & National Virtual & Reality Experimental Education Center for Medical Morphology (Southern Medical University) & National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China., Shi Y; Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics & Guangdong Engineering Research Center for Translation of Medical 3D Printing Application & National Virtual & Reality Experimental Education Center for Medical Morphology (Southern Medical University) & National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China., Liu J; Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics & Guangdong Engineering Research Center for Translation of Medical 3D Printing Application & National Virtual & Reality Experimental Education Center for Medical Morphology (Southern Medical University) & National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China., Li X; Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics & Guangdong Engineering Research Center for Translation of Medical 3D Printing Application & National Virtual & Reality Experimental Education Center for Medical Morphology (Southern Medical University) & National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China., Zhou Z; Central Laboratory, Southern Medical University, Guangzhou, Guangdong 510515, China., Chang Y; Department of Spine Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510515, China., Ouyang J; Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics & Guangdong Engineering Research Center for Translation of Medical 3D Printing Application & National Virtual & Reality Experimental Education Center for Medical Morphology (Southern Medical University) & National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China., Dai J; Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics & Guangdong Engineering Research Center for Translation of Medical 3D Printing Application & National Virtual & Reality Experimental Education Center for Medical Morphology (Southern Medical University) & National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.

Publikováno v: Genes & diseases [Genes Dis] 2024 Jul 26; Vol. 12 (2), pp. 101380. Date of Electronic Publication: 2024 Jul 26 (Print Publication: 2025).