Zobrazeno 1 - 10
of 115
pro vyhledávání: '"hétérochromatine"'
Autor:
Hogan, Ryan
La maladie d’Alzheimer (MA) représente la cause la plus importante de la démence, pourtant la cause de la MA reste toujours inconnue. Des données récentes suggèrent que la protéine BMI1 joue un rôle protecteur contre la MA et un rôle essent
Externí odkaz:
http://hdl.handle.net/1866/28249
Autor:
Abdulla, Amith Zafal
Publikováno v:
Biophysics. Ecole normale supérieure de lyon-ENS LYON, 2022. English. ⟨NNT : 2022ENSL0044⟩
A multitude of stable and heritable phenotypes arise from the same DNA sequence, owing to epigenetic regulatory mechanisms relying on the molecular cooperativity of ``reader-writer'' histone modifying enzymes. We introduce a unified modeling framewor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3393::72d01f2b60cba8d9507af1146206f4c5
https://theses.hal.science/tel-03968006/file/ABDULLA_A_Z_2022ENSL0044_These.pdf
https://theses.hal.science/tel-03968006/file/ABDULLA_A_Z_2022ENSL0044_These.pdf
Autor:
Pailles, Mélanie
Following fertilization, the embryonic genome undergoes various epigenetic and structural remodelings, essential for its activation. These various changes proceed further throughout development, as the embryo progresses from totipotency to pluripoten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______166::d89666fa5e191b7e66eda46c157cb8bf
https://pastel.archives-ouvertes.fr/tel-03943082
https://pastel.archives-ouvertes.fr/tel-03943082
Autor:
Hanna, Roy
La maladie d'Alzheimer (MA) est la démence la plus importante dans le monde développé. Cette maladie neurodégénérative rend de plus en plus difficile la capacité d'accomplir les tâches quotidiennes de routine, elle peut également faire oubli
Autor:
Bernard, Laure
Publikováno v:
Cellular Biology. Sorbonne Université, 2021. English. ⟨NNT : 2021SORUS179⟩
Histone H3 Lysine 9 (H3K9) methylation, a mark of heterochromatin, is progressively implemented during development to contribute to cell fate restriction as differentiation proceeds. For instance, in mouse Embryonic Stem cells (mESCs) the global leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8783667c117d4b4b444d8ae4b62c74df
https://theses.hal.science/tel-03474939
https://theses.hal.science/tel-03474939
Autor:
Casier, Karine
Publikováno v:
Génétique. Sorbonne Université, 2020. Français. ⟨NNT : 2020SORUS282⟩
Transposable elements (TE) are mobile DNA sequences that can be deleterious for genome integrity. In germ cells, TE activity is regulated by PIWI-Interacting RNAs (piRNAs), small non-coding RNA which are produced from specific sequences called piRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0a888838e57fa09a334272b296fdb409
https://tel.archives-ouvertes.fr/tel-03412902/document
https://tel.archives-ouvertes.fr/tel-03412902/document
Autor:
Casier, Karine
Publikováno v:
Génétique. Sorbonne Université, 2020. Français. ⟨NNT : 2020SORUS282⟩
Transposable elements (TE) are mobile DNA sequences that can be deleterious for genome integrity. In germ cells, TE activity is regulated by PIWI-Interacting RNAs (piRNAs), small non-coding RNA which are produced from specific sequences called piRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1398::0a888838e57fa09a334272b296fdb409
https://theses.hal.science/tel-03412902
https://theses.hal.science/tel-03412902
Autor:
Carlier, Florian
Pour se défendre des effets délétères des éléments transposables, les pezizomycotina ont développé un système de défense génétique et épigénétique appelé « Repeat Induced Point Mutation » (RIP). Chez N. crassa, le RIP survient dans
Externí odkaz:
http://www.theses.fr/2018SACLS457/document
Autor:
Chechik, Liubov
Publikováno v:
Agricultural sciences. Université de Strasbourg, 2020. English. ⟨NNT : 2020STRAJ033⟩
Multiple parameters can influence DNA repair, including local chromatin organization around the damage site, cell differentiation status, and a cell cycle state. Developing a CRISPR/Cas9 system in mouse embryonic stem cells for specific targeting chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::071a286dc3316ff5cd1fcda8d6415cac
https://theses.hal.science/tel-03325159
https://theses.hal.science/tel-03325159
Autor:
Mitrentsi, Ioanna
Various types of agents constantly assault DNA. DNA double-strand breaks (DSBs) are the most toxic lesions because their unfaithful repair leads to chromosomal translocations, and cancer. Heterochromatin (HC), which is highly condensed and restricts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______166::b78b9a42187cd8fdbebef36096631b04
https://theses.hal.science/tel-03934681
https://theses.hal.science/tel-03934681