Zobrazeno 1 - 10
of 4 571
pro vyhledávání: '"guide RNA"'
Autor:
Andrés Gómez-Palacio, Lissa Cruz-Saavedra, Frederik Van den Broeck, Manon Geerts, Sebastián Pita, Gustavo A. Vallejo, Julio C. Carranza, Juan David Ramírez
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Trypanosoma cruzi causes Chagas disease and has a unique extranuclear genome enclosed in a structure called the kinetoplast, which contains circular genomes known as maxi- and minicircles. While the structure and function of maxicircles are
Externí odkaz:
https://doaj.org/article/79e5d453eae54d0191e1af98d2d95bf2
Autor:
Brandon D. Hoenig, Jakub Zegar, Michel E. B. Ohmer, Macie M. Chess, Brady A. Porter, Myah Madril, Corinne L. Richards‐Zawacki
Publikováno v:
Methods in Ecology and Evolution, Vol 14, Iss 12, Pp 3055-3067 (2023)
Abstract The field of ecology has undergone a molecular revolution, with researchers increasingly relying on DNA‐based methods for organism detection. Unfortunately, these techniques often require expensive equipment, dedicated laboratory spaces an
Externí odkaz:
https://doaj.org/article/903e645768454347af059b4128bae12c
Autor:
David A. Armstrong, Taylor R. Hudson, Christine A. Hodge, Thomas H. Hampton, Alexandra L. Howell, Matthew S. Hayden
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 296-305 (2023)
Gene editing using CRISPR/Cas (clustered regularly interspaced palindromic repeats/CRISPR-associated) is under development as a therapeutic tool for the modification of genes in eukaryotic cells. While much effort has focused on CRISPR/Cas9 systems f
Externí odkaz:
https://doaj.org/article/3092a982d9e24dcfb4b7f3197bde4b92
Autor:
Tomomi Nakahara, Hirotaka Tabata, Yuya Kato, Ryoko Fuse, Mariko Nakamura, Megumi Yamaji, Nobutaka Hattori, Tohru Kiyono, Izumu Saito, Tomoko Nakanishi
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8783 (2024)
CRISPR/Cas9 technology is expected to offer novel genome editing-related therapies for various diseases. We previously showed that an adenovirus vector (AdV) possessing eight expression units of multiplex guide RNAs (gRNAs) was obtained with no delet
Externí odkaz:
https://doaj.org/article/925938859eb24f219100d98f2be8b9b7
Akademický článek
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Publikováno v:
Data in Brief, Vol 53, Iss , Pp 110237- (2024)
This dataset contains the gene sequences of the small and large sub-unit of the hydrogenase enzyme obtained from the annotated genome of Rhodobacter johrii MAY2. The whole genome sequence of the isolate was performed using SEED genome viewer on the R
Externí odkaz:
https://doaj.org/article/c3d112aec5f648f9bda8f2a338b016f3
Autor:
Anil Karmacharya, Dandan Li, Yueqiang Leng, Gongjun Shi, Zhaohui Liu, Shengming Yang, Yang Du, Wenhao Dai, Shaobin Zhong
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 36, Iss 9, Pp 554-557 (2023)
Two genes (TaHRC and Tsn1) conferring susceptibility to Fusarium head blight and tan spot, Septoria nodorum blotch, and spot blotch in wheat were targeted through wide hybridization with maize expressing Cas9 and guide RNA (gRNA). For each gene, two
Externí odkaz:
https://doaj.org/article/237ade21d8cd41be920ce87d3b38fcfc
Autor:
Xing Yin, Romain Harmancey, Brion Frierson, Jean G. Wu, Melanie R. Moody, David D. McPherson, Shao-Ling Huang
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 343 (2024)
Liposomes as carriers for CRISPR/Cas9 complexes represent an attractive approach for cardiovascular gene therapy. A critical barrier to this approach remains the efficient delivery of CRISPR-based genetic materials into cardiomyocytes. Echogenic lipo
Externí odkaz:
https://doaj.org/article/ef690dc39b7c4000b75859acabbaaf37
Autor:
Sophia Nazir
Publikováno v:
Talanta Open, Vol 7, Iss , Pp 100225- (2023)
The immune systems of bacteria and archaea served as the inspiration for CRISPR/Cas technology, which won the 2020 Nobel Prize in Chemistry for its achievements in genetic manipulation. Because of its enormous value globally, molecular diagnostics em
Externí odkaz:
https://doaj.org/article/8e22e3c7e46d420db6f3874025cb1a42
Autor:
Minhyeok Lee
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
In genetic engineering, the revolutionary CRISPR-Cas system has proven to be a vital tool for precise genome editing. Simultaneously, the emergence and rapid evolution of deep learning methodologies has provided an impetus to the scientific explorati
Externí odkaz:
https://doaj.org/article/20f5ddc19a8740bba1c7612d761b9085