Zobrazeno 1 - 10
of 3 094
pro vyhledávání: '"gsk-3β"'
Autor:
A. Markovska, K. Somers, J. Guillaume, J. Melief, A. P. Mazar, D. M. Schmitt, H. S. Schipper, M. Boes
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The prognosis of patients with high-risk neuroblastoma remains poor, partly due to inadequate immune recognition of the tumor. Neuroblastomas display extremely low surface MHC-I, preventing recognition by cytotoxic T lymphocytes (CTLs) and c
Externí odkaz:
https://doaj.org/article/2d883a7222ed4916b7cb4780cb1ff82d
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Purpose Pancreatic cancer is a lethal malignancy with a grim prognosis. Previous studies have proven that Leucine Rich Repeat of Flightless-1 Interacting Protein 1 (LRRFIP1) plays a pivotal role in cell biological processes, while its clinic
Externí odkaz:
https://doaj.org/article/eff043d1a9eb4ff4866a85b055ca54e3
Publikováno v:
F1000Research, Vol 13 (2024)
Background The discovery of an ideal and effective therapy is urgently required for the treatment of Alzheimer’s disease. The main pathological hallmarks of Alzheimer’s disease that appear before the clinical symptoms are neurofibrillary tangles,
Externí odkaz:
https://doaj.org/article/850dcddb5ca34934bc35a260ba167507
Autor:
Jiageng Guo, Xinya Jiang, Jing Lian, Huaying Li, Fan Zhang, Jinling Xie, Jiagang Deng, Xiaotao Hou, Zhengcai Du, Erwei Hao
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The PI3K/AKT/GSK-3β signaling pathway plays a pivotal role in numerous physiological and pathological processes, including cell proliferation, apoptosis, differentiation, and metabolic regulation. Aberrant activation of the PI3K/AKT pathway is intri
Externí odkaz:
https://doaj.org/article/3c84d6e9fdfc4cfe999ee9599ed7be00
Publikováno v:
F1000Research, Vol 13 (2024)
Background The discovery of an ideal and effective therapy is urgently required for the treatment of Alzheimer’s disease. The main pathological hallmarks of Alzheimer’s disease that appear before the clinical symptoms are neurofibrillary tangles,
Externí odkaz:
https://doaj.org/article/426077cfaff34ca9af4643809c5199de
Autor:
Congmin Wang, Yu Hei, Yu Liu, Akhilesh Kumar Bajpai, Yuhe Li, Yawen Guan, Fuyi Xu, Cuifang Yao
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
As a dietary strategy, methionine restriction has been reported to promote longevity and regulate metabolic disorders. However, the role and possible regulatory mechanisms underlying methionine in neurodegenerative diseases such as Alzheimer's diseas
Externí odkaz:
https://doaj.org/article/bcb6e7737a8b4d879f3aea2ed84a3ac6
Autor:
Noura Almusallam, Asma Alonazi, Anfal Bin Dayel, Abdullah Almubarak, Rizwan Ali, Wajd Althakfi, Rehab Ali, Nouf Alrasheed
Publikováno v:
Saudi Pharmaceutical Journal, Vol 32, Iss 7, Pp 102102- (2024)
Post-acute myocardial infarction (AMI) fibrosis is a pathophysiologic process characterised by activation of the profibrotic mediator, transforming growth factor-β (TGF-β). AMI is associated with a substantial increase in the levels of extracellula
Externí odkaz:
https://doaj.org/article/770b20693573475cb798de3d124875be
Publikováno v:
PeerJ, Vol 12, p e17538 (2024)
Background Gynostemma pentaphyllum (Thunb.) Makino, a well-known edible and medicinal plant, has anti-aging properties and is used to treataging-associated conditions such as diabetes, metabolic syndrome, and cardiovascular diseases. Gypenosides (GYP
Externí odkaz:
https://doaj.org/article/42c467da0a164b00b5de5c3caee53059
Autor:
Yasmeen Attia, Andrew Hakeem, Rawda Samir, Aya Mohammed, Abdullrahman Elsayed, Alaa Khallaf, Eman Essam, Hossameldeen Amin, Sarah Abdullah, Salwan Hikmat, Tarek Hossam, Ziad Mohamed, Ziad Aboelmagd, Olfat Hammam
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Sympathetic activation triggered by chronic stress afflicting cancer survivors is an emerging modulator of tumorigenesis. Adrenergic blockade was previously associated with improving response to doxorubicin (DOX) in triple-negative breast cancer (TNB
Externí odkaz:
https://doaj.org/article/3324adced0164872bd38f0817617f695
Autor:
Neha Chauhan, Sarvesh Paliwal, Swapnil Sharma, Smita Jain, Kritika Madan, Ajita Paliwal, Pragya Sharma, Achal Mishra, Popat Mohite, Vijay Chidrawar, Sudarshan Singh
Publikováno v:
Results in Chemistry, Vol 8, Iss , Pp 101595- (2024)
This study aimed to decipher the encoded information within the molecular structure of a dataset of GSK-3β inhibitors through a comprehensive quantity structural-activity relationship (QSAR) investigation employing traditional physicochemical descri
Externí odkaz:
https://doaj.org/article/dfd26e6e6e7b4a7abb94e57983d390a0