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Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91phox to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock☆

Autor: Meltem Kacan, Mehmet Sami Serin, Seyhan Sahan-Firat, Tuba Cuez, Wolf-Hagen Schunck, Demet Unsal, Bahar Tunctan, Belma Korkmaz, Ayse Nihal Sari, C. Kemal Buharalioglu, John R. Falck, Vijaya L. Manthati, Kafait U. Malik

We have previously demonstrated that a stable synthetic analog of 20-hydroxyeicosatetraenoic acid (20-HETE), N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine(5,14-HEDGE), prevents vascular hyporeactivity, hypotension, tachycardia, and inflammation in r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d84cc9e48f54984ba71367eb96ad87f
https://europepmc.org/articles/PMC3759626/

Peptide-Based Inhibitors Of The Phagocyte Nadph Oxidase

Autor: Jamel El-Benna, Axel Périanin, Pham My-Chan Dang

Publikováno v: Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2010, 80 (6), pp.778. ⟨10.1016/j.bcp.2010.05.020⟩
Biochemical Pharmacology, Elsevier, 2010, 80 (6), pp.778. 〈10.1016/j.bcp.2010.05.020〉

International audience; Phagocytes such as neutrophils, monocytes and macrophages play an essential role in host defenses against pathogens. To kill these pathogens, phagocytes produce and release large quantities of antimicrobial molecules such as r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88df29bc4b2b57f151a8525753d9f051
https://hal.archives-ouvertes.fr/hal-00608935/document

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