Zobrazeno 1 - 10
of 101
pro vyhledávání: '"glycyl radical enzyme"'
Autor:
Lindsey RF Backman, Yolanda Y Huang, Mary C Andorfer, Brian Gold, Ronald T Raines, Emily P Balskus, Catherine L Drennan
Publikováno v:
eLife, Vol 9 (2020)
The glycyl radical enzyme (GRE) superfamily utilizes a glycyl radical cofactor to catalyze difficult chemical reactions in a variety of anaerobic microbial metabolic pathways. Recently, a GRE, trans-4-hydroxy-L-proline (Hyp) dehydratase (HypD), was d
Externí odkaz:
https://doaj.org/article/64ac6c8a88dd48e7a634542c4722d87a
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT An increasing number of microbes are being identified that organize catabolic pathways within self-assembling proteinaceous structures known as bacterial microcompartments (BMCs). Most BMCs are characterized by their singular substrate speci
Externí odkaz:
https://doaj.org/article/7599856cafe04959bcd2636313609d45
Publikováno v:
The Journal of Biological Chemistry
Pyruvate formate-lyase (PFL) is a glycyl radical enzyme (GRE) that converts pyruvate and coenzyme A into acetyl-CoA and formate in a reaction that is crucial to the primary metabolism of many anaerobic bacteria. The glycyl radical cofactor, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e490975dd06ba9009cd5177b4a6972
https://doi.org/10.1016/j.jbc.2021.101423
https://doi.org/10.1016/j.jbc.2021.101423
Autor:
Jay D. Keasling, Harry R. Beller, Aindrila Mukhopadhyay, Andria V. Rodrigues, Dean J. Tantillo
Publikováno v:
Chembiochem
Chembiochem : a European journal of chemical biology, vol 21, iss 5
Rodrigues, A V, Tantillo, D J, Mukhopadhyay, A, Mukhopadhyay, A, Keasling, J & Beller, H R 2020, ' Insights into the Mechanism of Phenylacetate Decarboxylase (PhdB), a Toluene-Producing Glycyl Radical Enzyme ', ChemBioChem, vol. 21, no. 5, pp. 663-671 . https://doi.org/10.1002/cbic.201900560
Chembiochem : a European journal of chemical biology, vol 21, iss 5
Rodrigues, A V, Tantillo, D J, Mukhopadhyay, A, Mukhopadhyay, A, Keasling, J & Beller, H R 2020, ' Insights into the Mechanism of Phenylacetate Decarboxylase (PhdB), a Toluene-Producing Glycyl Radical Enzyme ', ChemBioChem, vol. 21, no. 5, pp. 663-671 . https://doi.org/10.1002/cbic.201900560
We recently reported the discovery of phenylacetate decarboxylase (PhdB), representing one of only ten glycyl‐radical‐enzyme reaction types known, and a promising biotechnological tool for first‐time biochemical synthesis of toluene from renewa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070bdd90b9b9c05737f5eec52cf14890
http://europepmc.org/articles/PMC7079210
http://europepmc.org/articles/PMC7079210
Autor:
Peck, Spencer C., Denger, Karin, Burrichter, Anna Georga, Irwin, Stephania M., Balskus, Emily P., Schleheck, David
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance This paper describes a pathway for anaerobic bacterial metabolism of taurine (2-aminoethanesulfonate), an abundant substrate in the human intestinal microbiota, by the intestinal bacterium and opportunistic pathogen, Bilophila wadsworthi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a9faf23bb628f7366c7a4d54412a7430
http://europepmc.org/articles/PMC6386719
http://europepmc.org/articles/PMC6386719
Autor:
Emily P. Balskus, Ronald T. Raines, Mary C. Andorfer, Catherine L. Drennan, Lindsey R. F. Backman, Yolanda Y. Huang, Brian Gold
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
The glycyl radical enzyme (GRE) superfamily utilizes a glycyl radical cofactor to catalyze difficult chemical reactions in a variety of anaerobic microbial metabolic pathways. Recently, a GRE, trans-4-hydroxy-L-proline (Hyp) dehydratase (HypD), was d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fd0aa8339702be4641a42a2fb2512a
http://europepmc.org/articles/PMC7077986
http://europepmc.org/articles/PMC7077986
Akademický článek
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Akademický článek
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Autor:
Stephania M. Irwin, Christopher D. Dawson, Jennifer X. Wang, Heather J. Kulik, Emily P. Balskus, Vyshnavi Vennelakanti, Chip Le, Catherine L. Drennan, Zhongyue Yang, Lindsey R. F. Backman
Publikováno v:
Cell Chemical Biology
Summary Desulfonation of isethionate by the bacterial glycyl radical enzyme (GRE) isethionate sulfite-lyase (IslA) generates sulfite, a substrate for respiration that in turn produces the disease-associated metabolite hydrogen sulfide. Here, we prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398736d2c305685143888f5472ac3056
https://doi.org/10.1016/j.chembiol.2021.03.001
https://doi.org/10.1016/j.chembiol.2021.03.001
Akademický článek
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