PEX1 is essential for glycosome biogenesis and trypanosomatid parasite survival

Autor: Lavanya Mahadevan, Hemant Arya, Andrea Droste, Wolfgang Schliebs, Ralf Erdmann, Vishal C. Kalel

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Trypanosomatid parasites are kinetoplastid protists that compartmentalize glycolytic enzymes in unique peroxisome-related organelles called glycosomes. The heterohexameric AAA-ATPase complex of PEX1-PEX6 is anchored to the peroxisomal membrane and fu

Externí odkaz: https://doaj.org/article/2bcff8bf4e84481eb18fa2381e714618

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A Small Molecule Inhibitor of Pex3–Pex19 Interaction Disrupts Glycosome Biogenesis and Causes Lethality in Trypanosoma brucei

Autor: Hiren Banerjee, Paul LaPointe, Gary Eitzen, Richard A. Rachubinski

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Trypanosomatid parasites, including Trypanosoma and Leishmania, are infectious zoonotic agents for a number of severe diseases such as African sleeping sickness and American trypanosomiasis (Chagas disease) that affect millions of people, mostly in t

Externí odkaz: https://doaj.org/article/9a7b2ab65b754f2e8cdd5274da38ad9c

A trypanosoma cruzi phosphoglycerate kinase isoform with a per-arnt-sim domain acts as a possible sensor for intracellular conditions

Autor: Rojas-Pirela, Maura, Delgado, Andrea, Rondón-Guerrero, Yossmayer d.C., Cáceres, Ana J., Michels, Paul A.M., Concepción, Juan Luis, Quiñones, W

Publikováno v: Rojas-Pirela, M, Delgado, A, Rondón-Guerrero, Y D C, Cáceres, A J, Michels, P A M, Concepción, J L & Quiñones, W 2023, ' A trypanosoma cruzi phosphoglycerate kinase isoform with a per-arnt-sim domain acts as a possible sensor for intracellular conditions ', Experimental Parasitology, vol. 251, no. 108574, 108574 . https://doi.org/10.1016/j.exppara.2023.108574

Per-ARNT-Sim (PAS) domains constitute a family of domains present in a wide variety of prokaryotic and eukaryotic organisms. They form part of the structure of various proteins involved in diverse cellular processes. Regulation of enzymatic activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::27f0b3de66435a55e64f0577dba7196e
https://www.pure.ed.ac.uk/ws/files/361130661/Rojas_et_al_Exp_Parasitol_accepted_ms.pdf

Positional Dynamics and Glycosomal Recruitment of Developmental Regulators during Trypanosome Differentiation

Autor: Balázs Szöőr, Dorina V. Simon, Federico Rojas, Julie Young, Derrick R. Robinson, Timothy Krüger, Markus Engstler, Keith R. Matthews

Publikováno v: mBio, Vol 10, Iss 4 (2019)

ABSTRACT Glycosomes are peroxisome-related organelles that compartmentalize the glycolytic enzymes in kinetoplastid parasites. These organelles are developmentally regulated in their number and composition, allowing metabolic adaptation to the parasi

Externí odkaz: https://doaj.org/article/db74b9b8f9794d29b042d9f4235b3304