Výsledky vyhledávání - "glycolithocholic acid"

Autor: Grzych, Guillaume, Chavez-Talavera, Oscar, Descat, Amandine, Thuillier, Dorothee, Verrijken, An, Kouach, Mostafa, Legry, Vanessa, Verkindt, Helene, Raverdy, Violeta, Legendre, Benjamin, Caiazzo, Robert, Van Gaal, Luc, Goossens, Jean-Francois, Paumelle, Rejane, Francque, Sven, Pattou, Francois, Haas, Joel T., Tailleux, Anne, Staels, Bart

Publikováno v: JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, 2021, 3 (2), pp.100222. ⟨10.1016/j.jhepr.2020.100222⟩
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (2), pp.100222. ⟨10.1016/j.jhepr.2020.100222⟩
JHEP Reports
JHEP Reports, Vol 3, Iss 2, Pp 100222-(2021)

Background & Aims Plasma bile acids (BAs) have been extensively studied as pathophysiological actors in non-alcoholic steatohepatitis (NASH). However, results from clinical studies are often complicated by the association of NASH with type 2 diabetes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::74e69ecb4a62b415846d1ee012802a9c
https://www.hal.inserm.fr/inserm-03173334/document

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Potent suppression of hydrophobic bile acids by aldafermin, an FGF19 analogue, across metabolic and cholestatic liver diseases

Autor: Hsiao D. Lieu, Gideon M. Hirschfield, Arun J. Sanyal, Stephen A. Harrison, Lei Ling, Ulrich Beuers, Alex M. DePaoli

Publikováno v: JHEP Reports
JHEP Reports, Vol 3, Iss 3, Pp 100255-(2021)
JHEP Reports, 3(3):100255. Elsevier

Summary Background & Aims Higher serum bile acid levels are associated with an increased risk of cirrhosis and liver-related morbidity and mortality. Herein, we report secondary analyses of aldafermin, an engineered analogue of the gut hormone fibrob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7001e197981d0d939e7dc5af50542f
https://pubmed.ncbi.nlm.nih.gov/33898959

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Hydrophobicity-tuned anion responsiveness underlies endosomolytic cargo delivery mediated by amphipathic vehicle peptides

Autor: Shuangshuang Ji, Hao Fei, Xiaolong Chen, Hanjie Liu, Ang Li

Publikováno v: The Journal of Biological Chemistry

Peptide conformation can change subject to environment cues. This concept also applies to many cationic amphipathic peptides (CAPs) known to have cell membrane lytic or penetrative activities. Well-conditioned CAPs can match the properties of the tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e5bcc1c77a58618c41d844f8e23287
https://doi.org/10.1016/j.jbc.2021.101364

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Akademický článek

Bile acid sulfates. II. Formation, metabolism, and excretion of lithocholic acid sulfates in the rat

Autor: ROBERT H. PALMER

Publikováno v: Journal of Lipid Research, Vol 12, Iss 6, Pp 680-687 (1971)

Sulfate esterification has been shown previously to be a prominent feature of lithocholate metabolism in man. These studies were undertaken to ascertain whether this metabolic pathway is also present in rats, and to investigate the physiological sign

Externí odkaz: https://doaj.org/article/f5d1dbf24744468fbc795fe644f53f65

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Spread monomolecular films of monohydroxy bile acids and their salts: influence of hydroxyl position, bulk pH, and association with phosphatidylcholine

Autor: Martin C. Carey, Melissa A. Bogle, Monika R. Leonard, Joanne M. Donovan

Publikováno v: Biochemistry. 39(51)

Undissociated dihydroxy bile acids, alone or with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), lie with their long axes parallel to aqueous-lipid interfaces [Fahey, D. A., Carey, M. C., and Donovan, J. M. (1995) Biochemistry 34, 10886-108

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d805a4726be8a8edaa712cdf7ff346
https://pubmed.ncbi.nlm.nih.gov/11123934

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Akademický článek

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Konjugierte Gallensäuren und sulfatierte Glykolithocholsäure im Serum gesunder Probanden

Autor: M. Winkler, J. Weber, G. Mauritz, H. Stang, H. J. Wildgrube, D. Schiller, H. Campana

Publikováno v: cclm. 20:319-324

Using commercially available radioimmunoassays, bile acids were measured in the serum of 378 healthy probands. The following values were found: conjugated cholic acid 0.36 +/- 0.38 mumol/l (95% percentile 1.28 mumol/l) (CG-radioimmunoassay from Abbot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b559be4e42f705f146bdea866fac5b6
https://doi.org/10.1515/cclm.1982.20.5.319

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Cholestasis induced by sulphated glycolithocholic acid in the rat: protection by endogenous bile acids

Autor: Roel J. Vonk, Folkert Kuipers, Rick Havinga

Publikováno v: Clinical science (London, England : 1979). 68(2)

1. Sulphated glycolithocholic acid (SGLC) causes cholestasis in experimental animals, despite its sulphated form. In the present study, the cholestatic potency and the pharmacokinetics of SGLC were investigated in rats under two conditions: (a) in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d765916f0e81deea70f86ae0b4a229
https://pubmed.ncbi.nlm.nih.gov/3967462

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