Animal models of haploinsufficiency revealed the isoform-specific role of GSK-3 in HFD-induced obesity and glucose intolerance.

Autor: Gupte M; Department of Biology, Austin Peay State University, Clarksville, Tennessee, United States., Umbarkar P; Division of Cardiovascular Diseases, U.A.B. | University of Alabama at Birmingham, Birmingham, Alabama, United States., Lemon J; Department of Biology, Austin Peay State University, Clarksville, Tennessee, United States., Tousif S; Division of Cardiovascular Diseases, U.A.B. | University of Alabama at Birmingham, Birmingham, Alabama, United States., Lal H; Division of Cardiovascular Diseases, U.A.B. | University of Alabama at Birmingham, Birmingham, Alabama, United States.

Publikováno v: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2024 Dec 01; Vol. 327 (6), pp. C1349-C1358. Date of Electronic Publication: 2024 Sep 30.

Design, synthesis and biological evaluation of thieno[3,2-c]pyrazol-urea derivatives as potent glycogen synthase kinase 3β inhibitors based on the DFG-out conformation.

Autor: Yan N; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China., Liu HY; The People's Hospital of Zhaoyuan City, No. 168 Yingbin Road, Zhaoyuan 265400, PR China., Kong TT; Department of Pharmacy, Qilu Hospital of Shandong University, Shandong University, Jinan 250012, PR China., Kong ZH; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China., Li LY; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China., Ma X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China., Zeng YL; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China., Wang MJ; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China., Tang LQ; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China., Zhang CM; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China. Electronic address: zhangcm@sdu.edu.cn., Liu ZP; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China. Electronic address: liuzhaop@sdu.edu.cn., Liu C; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China. Electronic address: chaoliu@sdu.edu.cn.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Nov 01; Vol. 112, pp. 129932. Date of Electronic Publication: 2024 Aug 28.

Myeloid GSK3α Deficiency Reduces Lesional Inflammation and Neovascularization during Atherosclerotic Progression.

Autor: Patel S; The Thrombosis and Atherosclerosis Research Institute, Hamilton, ON L8L 2X2, Canada., Shah N; The Thrombosis and Atherosclerosis Research Institute, Hamilton, ON L8L 2X2, Canada., D'Mello B; The Thrombosis and Atherosclerosis Research Institute, Hamilton, ON L8L 2X2, Canada.; Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada., Lee A; The Thrombosis and Atherosclerosis Research Institute, Hamilton, ON L8L 2X2, Canada., Werstuck GH; The Thrombosis and Atherosclerosis Research Institute, Hamilton, ON L8L 2X2, Canada.; Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.; Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Oct 10; Vol. 25 (20). Date of Electronic Publication: 2024 Oct 10.

Pharmacological regeneration of sensory hair cells restores afferent innervation and vestibular function.

Autor: Lahlou H; Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.; Eaton-Peabody Laboratory, Massachusetts Eye and Ear, Boston, Massachusetts, USA., Zhu H; Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA., Zhou W; Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA., Edge AS; Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.; Eaton-Peabody Laboratory, Massachusetts Eye and Ear, Boston, Massachusetts, USA.; Harvard Stem Cell Institute; Cambridge, Massachusetts, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Sep 24; Vol. 134 (22). Date of Electronic Publication: 2024 Sep 24.

Effects of 625 nm light-emitting diode irradiation on preventing ER stress-induced apoptosis via GSK-3β phosphorylation in MC3T3-E1.

Autor: Fu W; Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju, Korea., Liu G; Department of Endodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.; Department of Conservative Dentistry, School of Dentistry, Dental Science Research Institute, Chonnam National University, Gwangju, Korea., Kim SH; Department of Oral Anatomy, School of Dentistry, Dental Science Research Institute, Chonnam National University, Gwangju, Korea., Kim B; Department of Oral Medicine, School of Dentistry, Chonnam National University, Gwangju, Korea., Kim OS; Department of Periodontology, School of Dentistry, Chonnam National University, Gwangju, Korea., Ma G; Department of Oral and Maxillofacial Surgery, School of Stomatology, Dalian Medical University, Dalian, China., Yang Y; Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju, Korea.; Dental Implant Center, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China., Liu D; Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju, Korea., Zhu S; Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju, Korea., Kang JS; Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju, Korea., Kim O; Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju, Korea.

Publikováno v: Photochemistry and photobiology [Photochem Photobiol] 2024 Sep-Oct; Vol. 100 (5), pp. 1408-1418. Date of Electronic Publication: 2024 Jan 12.