Reprogramming alternative macrophage polarization by GATM-mediated endogenous creatine synthesis: A potential target for HDM-induced asthma treatment

Autor: Li Yu, Lingwei Wang, Guang Hu, Laibin Ren, Chen Qiu, Shun Li, Xiaohui Zhou, Shanze Chen, Rongchang Chen

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Cellular energy metabolism plays a crucial role in the regulation of macrophage polarization and in the execution of immune functions. A recent study showed that Slc6a8-mediated creatine uptake from exogenous supplementation modulates macrophage pola

Externí odkaz: https://doaj.org/article/99a4bd6465864c75bc08df2e5bb59483

A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism

Autor: Malte Stockebrand, Ali Sasani, Devashish Das, Sönke Hornig, Irm Hermans-Borgmeyer, Hannah A. Lake, Dirk Isbrandt, Craig A. Lygate, Arend Heerschap, Axel Neu, Chi-Un Choe

Publikováno v: Frontiers in Physiology
Frontiers in Physiology, Vol 9 (2018)
Frontiers in physiology 9, 773 (2018). doi:10.3389/fphys.2018.00773
Frontiers in Physiology, 9

Creatine serves as fast energy buffer in organs of high-energy demand such as brain and skeletal muscle. L-Arginine:glycine amidinotransferase (AGAT) and guanidinoacetate N-methyltransferase are responsible for endogenous creatine synthesis. Subseque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420826b6a4e8ea5aae0e1795acbe901e
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/193029

Creatine metabolism differs between mammals and rainbow trout (Oncorhynchus mykiss)

Autor: Andreas Borchel, Carsten Kühn, Alexander Rebl, Marieke Verleih, Tom Goldammer

Publikováno v: SpringerPlus
SpringerPlus, 3: 510

Creatine plays an important role in the cell as an energy buffer. As the energy system is a basic element of the organism it may possibly contribute to differences between rainbow trout strains selected for the traits growth and robustness, respectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934b6c0fba5690f3b3e95034ba42c574