Glutamate–Transporter Unbinding in Probabilistic Synaptic Environment Facilitates Activation of Distant NMDA Receptors

Autor: Leonid P. Savtchenko, Dmitri A. Rusakov

Publikováno v: Cells, Vol 12, Iss 12, p 1610 (2023)

Once outside the synaptic cleft, the excitatory neurotransmitter glutamate is rapidly bound by its high-affinity transporters, which are expressed in abundance on the surface of perisynaptic astroglia. While this binding and the subsequent uptake of

Externí odkaz: https://doaj.org/article/f782db8686824534ab06180e7489f474

Increased Extrasynaptic Glutamate Escape in Stochastically Shaped Probabilistic Synaptic Environment

Autor: Leonid P. Savtchenko, Dmitri A. Rusakov

Publikováno v: Biomedicines, Vol 10, Iss 10, p 2406 (2022)

Excitatory synapses in the brain are often surrounded by nanoscopic astroglial processes that express high-affinity glutamate transporters at a high surface density. This ensures that the bulk of glutamate leaving the synaptic cleft is taken up for i

Externí odkaz: https://doaj.org/article/22c57c224f6f4c8a98de2ff36492e59f

Long-Term Potentiation and Dual-Component Quantal Signaling in the Dentate Gyrus

Autor: Min, Ming-Yuan, Asztely, Fredrik, Kokaia, Merab, Kullmann, Dimitri M.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1998 Apr . 95(8), 4702-4707.

Externí odkaz: https://www.jstor.org/stable/44961

Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc

Autor: Anderson, Charles T., Radford, Robert J., Zastrow, Melissa L., Zhang, Daniel Y., Apfel, Ulf-Peter, Lippard, Stephen J., Tzounopoulos, Thanos

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2015 May . 112(20), E2705-E2714.

Externí odkaz: https://www.jstor.org/stable/26462868

Retraction of Astrocyte Leaflets From the Synapse Enhances Fear Memory

Autor: Aina Badia-Soteras, Tim S. Heistek, Mandy S.J. Kater, Aline Mak, Adrian Negrean, Michel C. van den Oever, Huibert D. Mansvelder, Baljit S. Khakh, Rogier Min, August B. Smit, Mark H.G. Verheijen

Publikováno v: Biological Psychiatry. Elsevier USA
Badia-Soteras, A, Heistek, T S, Kater, M S J, Mak, A, Negrean, A, van den Oever, M C, Mansvelder, H D, Khakh, B S, Min, R, Smit, A B & Verheijen, M H G 2023, ' Retraction of Astrocyte Leaflets From the Synapse Enhances Fear Memory ', Biological psychiatry, vol. 94, no. 3, pp. 226-238 . https://doi.org/10.1016/j.biopsych.2022.10.013
Badia-Soteras, A, Heistek, T S, Kater, M S J, Mak, A, Negrean, A, van den Oever, M C, Mansvelder, H D, Khakh, B S, Min, R, Smit, A B & Verheijen, M H G 2023, ' Retraction of Astrocyte Leaflets From the Synapse Enhances Fear Memory ', Biological Psychiatry, vol. 94, no. 3, pp. 226-238 . https://doi.org/10.1016/j.biopsych.2022.10.013
Biological psychiatry. Elsevier USA

BACKGROUND: The formation and retrieval of fear memories depends on orchestrated synaptic activity of neuronal ensembles within the hippocampus, and it is becoming increasingly evident that astrocytes residing in the environment of these synapses pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b22b58ec69e67049ea7aadd8cfb9f3
https://doi.org/10.1016/j.biopsych.2022.10.013