Zobrazeno 1 - 10
of 1 319
pro vyhledávání: '"glutamate excitotoxicity"'
Publikováno v:
Advanced Science, Vol 11, Iss 36, Pp n/a-n/a (2024)
Abstract Cytotoxic neuronal swelling and glutamate excitotoxicity are two hallmarks of ischemic stroke. However, the underlying molecular mechanisms are not well understood. Here, it is reported that SWELL1, the essential subunit of the volume‐regu
Externí odkaz:
https://doaj.org/article/b04777ce0b024b0b980dc3b894dbc7b9
Autor:
Diana I. Salikhova, Margarita O. Shedenkova, Anastasya K. Sudina, Ekaterina V. Belousova, Irina A. Krasilnikova, Anastasya A. Nekrasova, Zlata A. Nefedova, Daniil A. Frolov, Timur Kh. Fatkhudinov, Andrey V. Makarov, Alexander M. Surin, Kirill V. Savostyanov, Dmitry V. Goldshtein, Zanda V. Bakaeva
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Currently, stem cells technology is an effective tool in regenerative medicine. Cell therapy is based on the use of stem/progenitor cells to repair or replace damaged tissues or organs. This approach can be used to treat various diseases, such as car
Externí odkaz:
https://doaj.org/article/5c888d18a3214fff9434c731218e231b
Autor:
Lemeng Feng, Chao Wang, Cheng Zhang, Wulong Zhang, Weiming Zhu, Ye He, Zhaohua Xia, Weitao Song
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 10, Pp 2299-2309 (2024)
Glutamate excitotoxicity has been shown to play an important role in glaucoma, and glutamate can induce ferroptosis. The p38 mitogen-activated protein kinase (MAPK) pathway inhibitor SB202190 has a potential ability to suppress ferroptosis, and its d
Externí odkaz:
https://doaj.org/article/b7cfcda6a2b9407185bd2eaddd9a77b9
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 2, Pp 255-257 (2024)
During brain ischemia, excitotoxicity and peri-infarct depolarization injuries occur and cause cerebral tissue damage. Indeed, anoxic depolarization, consisting of massive neuronal depolarization due to the loss of membrane ion gradients, occurs in v
Externí odkaz:
https://doaj.org/article/42accd31e1c74a7ca015b53bee76921e
Akademický článek
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Publikováno v:
Cells, Vol 13, Iss 12, p 1006 (2024)
Excessive levels of glutamate activity could potentially damage and kill neurons. Glutamate excitotoxicity is thought to play a critical role in many CNS and retinal diseases. Accordingly, glutamate excitotoxicity has been used as a model to study ne
Externí odkaz:
https://doaj.org/article/56baccb034d346ad9ef01c37407dface
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 589 (2024)
Excitotoxicity is a common pathological process in neurological diseases caused by excess glutamate. The purpose of this study was to evaluate the effect of gypenoside XVII (GP-17), a gypenoside monomer, on the glutamatergic system. In vitro, in rat
Externí odkaz:
https://doaj.org/article/743063f75349485897f2aacfd380aede
Publikováno v:
Pharmaceuticals, Vol 17, Iss 3, p 393 (2024)
Glutamate excitotoxicity and oxidative stress represent two major pathological mechanisms implicated in retinal disorders. In Diabetic Retinopathy (DR), oxidative stress is correlated to NADPH oxidase (NOX), a major source of Reactive Oxygen Species
Externí odkaz:
https://doaj.org/article/3d1a56073b854f948a01eb5da2f323de
Autor:
Anissa Rym Saidia, Florence François, François Casas, Ilana Mechaly, Stéphanie Venteo, Joseph T. Veechi, Jérôme Ruel, Jean-Luc Puel, Jing Wang
Publikováno v:
Antioxidants, Vol 13, Iss 2, p 149 (2024)
The disruption of the synaptic connection between the sensory inner hair cells (IHCs) and the auditory nerve fiber terminals of the type I spiral ganglion neurons (SGN) has been observed early in several auditory pathologies (e.g., noise-induced or o
Externí odkaz:
https://doaj.org/article/2d39b64836784478ae6dc8b6e4031a8e
Akademický článek
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